Changes in Respiratory Viruses’ Activity in Children During the COVID-19 Pandemic: A Systematic Review
Journal of Clinical Medicine,
Год журнала:
2025,
Номер
14(4), С. 1387 - 1387
Опубликована: Фев. 19, 2025
Background/Objectives:
The
impact
of
the
coronavirus
disease
2019
(COVID-19)
pandemic
on
health
was
significant
worldwide.
measures
adopted
to
limit
spread
virus
had
an
indirect
effect
epidemiology
other
infectious
diseases
with
similar
mechanisms
inter-human
transmission.
present
literature
review
analyzed
scenario
pediatric
acute
respiratory
infections
in
post-lockdown
period
compared
pre-pandemic
and
lockdown
periods.
different
patterns
viruses'
outbreaks
were
evaluated
according
type
local
COVID-19
restrictive
pathogen.
Methods:
Relevant
scientific
published
between
March
2020
November
2024
identified
by
means
electronic
keyword
searches
PubMed,
Scopus,
Cochrane
Library
databases.
Results:
Worldwide
implementation
non-pharmacological
public
interventions
aimed
at
limiting
resulted
a
measurable
circulation
common
viruses,
significantly
affecting
their
usual
seasonality.
Most
viruses
reduced
activity
during
but
returned
or
exceeded
historical
levels
after
discontinuation
preventive
measures.
For
many
particularly
syncytial
virus,
off-season
increase
reported.
Conclusions:
interventions,
which
effectively
helped
pandemic,
relevant
epidemiologic
changes
most
viruses.
Given
seasonality
clinical
severity
observed
for
some
pathogens
lockdown,
possible
future
more
severe
epidemics
should
be
expected.
Язык: Английский
Role of Gut Microbiota in Long COVID: Impact on Immune Function and Organ System Health
Archives of Microbiology & Immunology,
Год журнала:
2025,
Номер
9(1)
Опубликована: Янв. 1, 2025
SARS-CoV-2
infection
has
led
to
a
range
of
long-lasting
symptoms,
collectively
referred
as
long
COVID.
Current
research
highlights
the
critical
role
angiotensin-converting
enzyme
2
(ACE2)
in
regulating
gut
microbiota
diversity,
vascular
function,
and
homeostasis
within
renin-angiotensin
system
(RAS).
ACE2
is
utilized
by
virus
enter
host
cells,
but
its
downregulation
following
contributes
dysbiosis
RAS
disruption.
These
imbalances
have
been
linked
COVID
including
joint
pain,
chest
chronic
cough,
fatigue,
brain
fog,
anxiety,
depression,
myalgia,
peripheral
neuropathy,
memory
difficulties,
impaired
attention.
This
review
investigates
dysregulation
caused
long-term
effects
it
on
various
organ
systems,
musculoskeletal,
neurological,
renal,
respiratory,
cardiovascular
systems.
We
explored
bidirectional
interactions
between
microbiota,
immune
these
focusing
how
inflammation
dysfunction
observed
symptoms.
Understanding
key
for
identifying
effective
therapeutic
strategies
interventional
targets
aimed
at
mitigating
impact
health
improving
patient
outcomes.
Язык: Английский
The stability and elimination of mammalian enveloped and non-enveloped respiratory viruses in indoor air: Testing using a room-sized aerobiology chamber
Journal of Virological Methods,
Год журнала:
2025,
Номер
unknown, С. 115144 - 115144
Опубликована: Март 1, 2025
We
assessed
the
viability
of
aerosolized
human
betacoronavirus
OC43
(HCoV-OC43;
ATCC
VR-1558),
rhinovirus-14
(RV-14;
VR-284)
and
feline
calicivirus
(FCV;
VR-782)
as
representative
enveloped
non-enveloped
respiratory
viruses
mammals
in
indoor
air
under
ambient
conditions
(relative
humidity
50±10%
temperature
22±2°C)
using
a
room-sized
(25
m3;
900
ft3)
aerobiology
chamber.
All
virus
suspensions
contained
soil
load
to
simulate
presence
body
fluids
they
were
separately
into
chamber
six-jet
Collison
nebulizer.
A
muffin
fan
was
used
uniformly
mix
inside
keep
aerosols
airborne.
slit
sampler
with
Petri
plates
containing
3%
(wt./vol)
gelatin
collect
samples.
The
liquefied
an
incubator
assayed
for
infectious
plaque-forming
units
(PFU).
rates
biological
decay
HCoV-OC43,
RV-14
FCV
0.0052±0.00026,
0.0034±0.0027
0.0081±0.0031
(as
log10
PFU/m3/min),
respectively.
also
HEPA
filter-based
stand-alone
purifier
against
experimentally
device
could
demonstrate
>3-log10
reductions
three
46,
62
41minutes,
Therefore,
we
can
now
investigate
stability
mammalian
well
decontamination
technologies
them
field-relevant
conditions.
Язык: Английский
Quantifying fomite hotspots and targeted hygiene impacts in a hotel lobby
International Journal of Hygiene and Environmental Health,
Год журнала:
2025,
Номер
267, С. 114586 - 114586
Опубликована: Апрель 29, 2025
Язык: Английский
The Impact of an Air Sanitizer Spray on Risk of Virus Transmission by Aerosols Generated by Toilet Flushing
Stephanie A. Boone,
Nicklous D Betts-Childress,
M. Khalid Ijaz
и другие.
American Journal of Infection Control,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Toilet
flushing
has
been
reported
to
result
in
pathogen
contamination
of
restroom
fomites
and
air.
The
goal
this
study
was
investigate
the
effectiveness
an
Air
Sanitizing
Spray
on
reducing
cross-contamination
air
after
toilet
flushing.
Bacteriophage
MS2
added
bowl
water
then
flushed,
were
determined.
Subsequently,
procedure
replicated
determine
interventional
role
using
either
Sanitizer
or
surface
Disinfectant
A
90
99.99%
reduction
occurred
with
use
depending
fomite
location
sanitizer
spray
duration.
Use
significantly
reduced
viral
only
seat
spraying
8
seconds,
but
a
30
second
4
5
surfaces.
also
by
99%
use.
In
contrast,
when
hard
sprayed
its
impact
post-flushing
negligible.
reduces
potential
airborne
exposure
from
including
risk
norovirus
transmission
restroom.
Язык: Английский
Impact of Different Toilet Cleaning/Disinfecting Regimens on Reducing the Risk of Exposure to Toilet-Borne Pathogens in American Household Restrooms
Hygiene,
Год журнала:
2025,
Номер
5(2), С. 22 - 22
Опубликована: Май 20, 2025
Restrooms
are
associated
with
the
transmission
of
bacterial
and
viral
illnesses.
Disinfecting
contaminated
surfaces
is
reducing
risk.
The
goal
this
study
was
to
determine
how
cleaning/disinfecting
frequency
affects
restroom
pathogen
contamination.
Phase
1
intervention
included
cleaning
toilet
(the
bowl,
water,
rim)
using
9.5%
w/w
hydrochloric
acid.
2
used
fomite-specific
products
clean/disinfect
additional
surfaces,
including
vanity
countertop,
sink
faucet
handle,
seat,
flush
floor,
doorknob.
A
designated
household
member
responsible
for
at
beginning
each
interval.
Fomite
sample
collection
randomized,
samples
were
tested
heterotrophic,
coliform,
Escherichia
coli
bacteria
after
specified
intervals:
1,
2,
3,
or
7
days.
greatest
numbers
largest
reductions
occurred
on
fomites
three
statistically
significant
difference
found
heterotrophic
(p
=
0.009),
coliforms
0.10),
E.
0.13)
every
quantitative
microbial
risk
assessment
(QMRA)
estimated
a
>98%
reduction
in
infection
by
norovirus
an
every-3-day
cleaning/disinfection
routine
most
heavily
sites.
Results
indicate
optimal
twice
weekly
minimizing
exposure
pathogens.
Язык: Английский
Rapid virucidal activity of an air sanitizer against aerosolized MS2 and Phi6 phage surrogates for non-enveloped and enveloped vertebrate viruses, including SARS-CoV-2
Applied and Environmental Microbiology,
Год журнала:
2024,
Номер
91(1)
Опубликована: Дек. 6, 2024
An
air
sanitizer
was
evaluated
using
an
aerobiology
protocol,
compliant
with
the
U.S.
Environmental
Protection
Agency's
Air
Sanitizer
Guidelines,
for
virucidal
activity
against
bacteriophages
Phi6
and
MS2
(used
as
surrogates
enveloped
non-enveloped
human
pathogenic
viruses).
The
phages
were
suspended
in
a
medium
containing
tripartite
soil
load
simulating
body
fluids
aerosolized
six-jet
Collison
nebulizer
enclosed
25
m3
chamber
at
22
±
2°C
50
10%
relative
humidity.
sprayed
into
30
s.
Viable
captured
directly,
real
time,
on
host
bacterial
lawns
slit-to-agar
sampler.
Reductions
viable
phage
concentration
≥3.0
log10
(99.9%)
observed
after
mean
exposure
of
3.6
min
Phi6,
suggesting
efficacy
viruses
(e.g.,
SARS-CoV-2,
influenza,
RSV),
~10.6
MS2,
noroviruses
rhinoviruses).
This
targeted
sanitization
approach
represents
important
non-pharmaceutical
public
health
intervention
airborne
viral
pathogens.IMPORTANCEAirborne
are
implicated
transmission
indoors
respiratory
enteric
infections.
sanitizers
represent
to
mitigate
risk
such
transmission.
We
have
developed
method
that
is
now
ASTM
International
standard
(ASTM
E3273-21)
well
test
protocol
approved
by
EPA
evaluate
sanitizing
sprays
inactivating
bacteriophage
viruses,
respectively).
individually
room-sized
maintained
ambient
temperature
SARS-CoV-2;
influenza;
data
suggest
utility
mitigating
indoor
during
pandemics
outbreaks.
Язык: Английский
Characterization of size-resolved aerosol hygroscopicity and liquid water content in Nanjing of the Yangtze River Delta
Journal of Environmental Sciences,
Год журнала:
2024,
Номер
151, С. 26 - 41
Опубликована: Март 28, 2024
Язык: Английский
Resuspension and Dissemination of MS2 Virus from Flooring After Human Activities in Built Environment: Impact of Dust Particles
Microorganisms,
Год журнала:
2024,
Номер
12(12), С. 2564 - 2564
Опубликована: Дек. 12, 2024
Resuspended
particles
from
human
activities
can
contribute
to
pathogen
exposure
via
airborne
fomite
contamination
in
built
environments.
Studies
investigating
the
dissemination
of
resuspended
viruses
are
limited.
The
goal
this
study
was
explore
viral
after
aerosolized
resuspension
on
indoor
flooring.
Nylon
carpet
or
wood
flooring
seeded
with
virus
(MS2)
laden
dust
then
evaluated
activities,
i.e.,
walking
and
vacuuming.
Statistically
significant
differences
were
found
dispersal
vacuuming
(p-value
=
5.8
×
10−6)
0.003,
distance
>
12
in/30
cm).
Significant
also
between
floor
materials
(p
2.09
10−5)
2.68
10−2).
A
quantitative
microbial
risk
assessment
(QMRA)
scenario
using
Norovirus
a
single
touch
followed
by
hand-to-mouth
indicated
statistically
difference
associated
carpet(p
<
0.001).
Infection
risks
1
5
log10
greater
for
exposure.
greatest
reductions
fomites
seen
across
no-dust
scenarios
surfaces
<30
cm
More
research
is
needed
determine
role
plays
transmission
potentially
infectious
agents.
Язык: Английский