Functional Features of Senescent Cells and Implications for Therapy DOI Open Access
Tatiana V. Kirichenko, Yuliya V. Markina, Alexander M. Markin

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(11), С. 5390 - 5390

Опубликована: Июнь 4, 2025

Cellular senescence is a key mechanism of aging. Senescent cells negatively affect the function tissues and organs, significantly contributimg to aging organism. Functional structural characteristics senescent cells, such as genomic changes cell cycle arrest, lysosome mitochondrial dysfunction, production SASP factors, are promising therapeutic targets in context healthy longevity. The present review was designed characterize features order discuss current methods problems geroprotective therapy perspective factors for development new strategies anti-aging treatment. Publications were searched based on analysis articles containing keywords “senescent aging, senolytic therapy, SASP, dysfunction” PubMed Scopus databases up March 2025.

Язык: Английский

Functional Features of Senescent Cells and Implications for Therapy DOI Open Access
Tatiana V. Kirichenko, Yuliya V. Markina, Alexander M. Markin

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(11), С. 5390 - 5390

Опубликована: Июнь 4, 2025

Cellular senescence is a key mechanism of aging. Senescent cells negatively affect the function tissues and organs, significantly contributimg to aging organism. Functional structural characteristics senescent cells, such as genomic changes cell cycle arrest, lysosome mitochondrial dysfunction, production SASP factors, are promising therapeutic targets in context healthy longevity. The present review was designed characterize features order discuss current methods problems geroprotective therapy perspective factors for development new strategies anti-aging treatment. Publications were searched based on analysis articles containing keywords “senescent aging, senolytic therapy, SASP, dysfunction” PubMed Scopus databases up March 2025.

Язык: Английский

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