Postural Orthostatic Tachycardia Syndrome Associated with COVID-19: A Narrative Review DOI Creative Commons
Jung‐Hyun Park,

So Min Park,

Na-Hye Kim

и другие.

Medicina, Год журнала: 2024, Номер 60(8), С. 1325 - 1325

Опубликована: Авг. 15, 2024

Postural orthostatic tachycardia syndrome (POTS) is a complex condition marked by an atypical autonomic response to standing, leading intolerance and significant without accompanying hypotension. In recent studies, considerable number of individuals recovering from COVID-19 have been reported experience POTS within 6 8 months post-infection. Key symptoms include fatigue, difficulty with tolerance, tachycardia, cognitive challenges. The underlying causes following remain unknown, various theories proposed such as renin–angiotensin–aldosterone system (RAAS) dysregulation, hyperadrenergic reaction, direct viral infection. Healthcare professionals should be vigilant for in patients who recovered are experiencing signs dysfunction use diagnostic procedures the tilt-up table test confirmation. COVID-19-related approached holistic strategy. Although many show improvement initial non-drug treatments, subjects do not respond exhibit more severe symptoms, medication-based therapies may necessary. current understanding limited, underscoring need research increase knowledge enhance treatment approaches.

Язык: Английский

Post-COVID dysautonomias: what we know and (mainly) what we don’t know DOI
David S. Goldstein

Nature Reviews Neurology, Год журнала: 2024, Номер 20(2), С. 99 - 113

Опубликована: Янв. 11, 2024

Язык: Английский

Процитировано

20
Possible Role of Fibrinaloid Microclots in Postural Orthostatic Tachycardia Syndrome (POTS): Focus on Long COVID DOI Open Access
Douglas B. Kell, Asad Khan,

Binita Kane

и другие.

Journal of Personalized Medicine, Год журнала: 2024, Номер 14(2), С. 170 - 170

Опубликована: Янв. 31, 2024

Postural orthostatic tachycardia syndrome (POTS) is a common accompaniment of variety chronic, inflammatory diseases, including long COVID, as are small, insoluble, 'fibrinaloid' microclots. We here develop the argument, with accompanying evidence, that fibrinaloid microclots, through their ability to block flow blood microcapillaries and thus cause tissue hypoxia, not simply correlated but in fact, by preceding it, may be chief intermediary POTS, which body's exaggerated 'physiological' response hypoxia. Similar reasoning accounts for symptoms bundled under term 'fatigue'. Amyloids known membrane disruptors, when targets nerve membranes, this can explain neurotoxicity hence autonomic nervous system dysfunction contributes POTS. Taken together view, we indicate microclots serve link POTS fatigue COVID manner at once both mechanistic explanatory. This has clear implications treatment such diseases.

Язык: Английский

Процитировано

8
Genetic risk factors for severe and fatigue dominant long COVID and commonalities with ME/CFS identified by combinatorial analysis DOI Creative Commons

Krystyna Taylor,

Matthew Pearson, Sayoni Das

и другие.

Journal of Translational Medicine, Год журнала: 2023, Номер 21(1)

Опубликована: Ноя. 1, 2023

Long COVID is a debilitating chronic condition that has affected over 100 million people globally. It characterized by diverse array of symptoms, including fatigue, cognitive dysfunction and respiratory problems. Studies have so far largely failed to identify genetic associations, the mechanisms behind disease, or any common pathophysiology with other conditions such as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) present similar symptoms.We used combinatorial analysis approach combinations variants significantly associated development long examine biological underpinning its various symptoms. We compared two subpopulations patients from Sano Genetics' GOLD study cohort, focusing on severe dominant phenotypes. evaluated signatures previously identified in an ME/CFS population against this understand similarities disorders may be triggered prior viral infection. Finally, we also output known associations diseases, range metabolic neurological disorders, overlap pathophysiological mechanisms.Combinatorial 73 genes were highly at least one populations included analysis. Of these, 9 acute COVID-19, 14 differentially expressed transcriptomic patients. A pathway enrichment revealed pathways most mainly aligned cardiometabolic diseases. Expanded genotype suggests specific SNX9 genotypes are significant contributor risk protection infection, but gene-disease relationship context dependent mediated interactions KLF15 RYR3. Comparison uniquely Severe Fatigue Dominant differences between enriched each subgroup. The unique immune myeloid differentiation macrophage foam cells. Genes subgroup MAPK/JNK signaling. ME/CFS, several involved circadian rhythm regulation insulin regulation. Overall, 39 SNPs can linked recent patient UK Biobank. Among COVID, 42 potentially tractable for novel drug discovery approaches, 13 these already targeted drugs clinical pipelines. From example, TLR4 antagonists repurposing candidates potential protect term impairment pathology caused SARS-CoV-2. currently evaluating targets use treating and/or ME/CFS.This demonstrates power analytics stratifying heterogeneous complex diseases do not simple monogenic etiologies. These results build upon findings analyses COVID-19 expect access additional independent, larger datasets will further improve disease insights validate treatment options COVID.

Язык: Английский

Процитировано

20
Post-COVID postural orthostatic tachycardia syndrome (POTS): a new phenomenon DOI Creative Commons
C. A. Cantrell, Conor Reid,

Claudia S. Walker

и другие.

Frontiers in Neurology, Год журнала: 2024, Номер 15

Опубликована: Март 22, 2024

Background The impact of COVID-19 has been far-reaching, and the field neurology is no exception. Due to long-hauler effect, a variety chronic health consequences have occurred for some post-COVID patients. A subset these patients experienced symptoms autonomic dysfunction tested positive postural orthostatic tachycardia syndrome (POTS) via testing. Methods We conducted chart review convenience sample from seen by neurologists at our tertiary care center suspicion POTS. Patients included in study had clearly defined POTS based on clinical criteria tilt table test, were 81.25% female, an average age approximately 36. Out 16 patients, 12 confirmed COVID test result, with remaining 4 having strong infection. Our analysis examined most bothersome 3 affecting each patient per neurologist’s note their initial visit POTS, presentation, comorbidities, neurological exam findings, testing results, COMPASS-31 questionnaire PROMIS fatigue survey results. Results Palpitations (68.75%) (62.5%) common impactful reported Cleveland Clinic visit. frequent comorbidities migraines (37.5%), irritable bowel (IBS) (18.75%), Raynaud’s (18.75%). Neurological findings results other than yielded variable without clear trends. Survey showed substantial symptom burden (COMPASS-31 score 44.45) high levels (PROMIS 64.64) Conclusion are similar diagnosed general population including Fatigue was identified as debilitating symptom. hope that will be early step toward further investigation focus trends this review.

Язык: Английский

Процитировано

6
Is joint hypermobility linked to self-reported non-recovery from COVID-19? Case–control evidence from the British COVID Symptom Study Biobank DOI Creative Commons
Jessica Eccles, Dorina Cadar, Lisa Quadt

и другие.

BMJ Public Health, Год журнала: 2024, Номер 2(1), С. e000478 - e000478

Опубликована: Фев. 1, 2024

This study sought to explore whether generalised joint hypermobility (GJH, a common marker of variant connective tissue) was risk factor for self-reported non-recovery from COVID-19 infection. Prospective observational study. COVID Symptom Study Biobank (https://cssbiobank.com/) UK. Participants were surveyed in August 2022. 3064 (81.4%) reported at least one infection with COVID-19. These individuals on recovery and completed self-report questionnaire detect GJH (Hakim Grahame 5-part questionnaire, 5PQ). The primary outcome the presence time survey. Additional outcomes included scores 5PQ fatigue level (Chalder Fatigue Scale). not specifically associated per se. However, it significantly (OR 1.43 (95% CI 1.20 1.70)). association remained after sequential models adjusting age, sex, ethnic group, education index multiple deprivation 1.33 1.10 1.61)) further adjustment vaccination status number vaccinations 1.60)). Additionally, including model all covariates, predicted higher levels (B=0.95, SE=0.25, t=3.77, SE, p=0.002). mediated link between (estimate indirect effect=0.18, 95% bootstrapped 0.08 0.29). Individuals approximately 30% more likely have recovered fully this level. observation is clinically important through its potential impact understanding identifying sub-phenotypes long screening personalised targeted interventions. More generally, greater awareness extra-articular associations needed effective patient stratification implementation medicine.

Язык: Английский

Процитировано

5
A review of post COVID syndrome pathophysiology, clinical presentation and management in children and young people DOI
Rebecca Johnston,

Samatha Sonnappa,

Anne‐Lise Goddings

и другие.

Paediatric Respiratory Reviews, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

4
Autoimmunity in Syndromes of Orthostatic Intolerance: An Updated Review DOI Open Access
Clarissa Pena,

Abdelmoniem Moustafa,

Abdel-Rhman Mohamed

и другие.

Journal of Personalized Medicine, Год журнала: 2024, Номер 14(4), С. 435 - 435

Опубликована: Апрель 20, 2024

Orthostatic intolerance is a broad term that represents spectrum of dysautonomic disorders, including postural orthostatic tachycardia syndrome (POTS) and hypotension (OH), as manifestations severe autonomic failure. While the etiology has not yet fully been uncovered, it associated with multiple underlying pathological processes, peripheral neuropathy, altered renin–aldosterone levels, hypovolemia, autoimmune processes. Studies have implicated adrenergic, cholinergic, angiotensin II type I autoantibodies in pathogenesis intolerance. Several case series demonstrated immunomodulation therapy resulted favorable outcomes, improving symptoms POTS OH. In this review, we highlight contemporary literature detailing association autoimmunity

Язык: Английский

Процитировано

4
COVID and nervous system: Mechanisms and consequences DOI
Federica Monaco, Marco Cascella

Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 413 - 435

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Long-COVID and postural orthostatic tachycardia syndrome: a preliminary comparison of neuropsychological performance DOI Creative Commons
Aitana Ruiz de Lazcano, Paula Pérez-Núñez, Mercè Pallarès‐Sastre

и другие.

Clinical Autonomic Research, Год журнала: 2025, Номер unknown

Опубликована: Янв. 22, 2025

Abstract Purpose The aim of the study is to analyze and compare cognitive profile between 59 patients with long-COVID [LC; 30 them 29 without a positive coronavirus disease 2019 (COVID-19) confirmatory test] 31 postural orthostatic tachycardia syndrome (POTS) matched group 39 healthy control participants. Methods Participants were examined on battery neuropsychological tests, including verbal memory, visuospatial abilities, attention, processing speed, fluency, working visual memory. Anxious–depressive symptomatology was also analyzed then controlled for possible influence performance. Results Patients LC POTS showed significantly lower performance compared peers. Differences anxious depressive symptoms found clinical groups, resulting in test exhibiting highest rates symptoms. After controlling effects anxious–depressive symptomatology, differences eliminated some variables, but additional after post hoc analysis. Conclusions Findings from present contribute toward reinforcement evidence alterations associated POTS. has be considered both groups since it could affecting

Язык: Английский

Процитировано

0
The Evolution of Head-Upright Tilt Table Testing in Toronto, Ontario, Canada: 2014-2024 DOI Creative Commons
Owais Mian, Russell J. de Souza, David Newman

и другие.

CJC Open, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0