World Journal of Clinical Pediatrics,
Год журнала:
2025,
Номер
14(2)
Опубликована: Март 18, 2025
BACKGROUND
Functional
gastrointestinal
disorders
(FGIDs)
in
children
present
with
chronic
symptoms
like
abdominal
pain,
diarrhea,
and
constipation
without
identifiable
structural
abnormalities.
These
are
closely
linked
to
gut-brain
axis
dysfunction,
altered
gut
microbiota,
psychosocial
stress,
leading
psychiatric
comorbidities
such
as
anxiety,
depression,
behavioral
issues.
Understanding
this
bidirectional
relationship
is
crucial
for
developing
effective,
holistic
management
strategies
that
address
physical
mental
health.
AIM
To
examine
the
impacts
of
FGIDs
children,
focusing
on
anxiety
depression
their
association
other
neurodevelopmental
childhood,
attention-deficit/hyperactivity
disorder,
emphasizing
role
axis,
emotional
dysregulation,
stress.
Key
mechanisms
explored
include
neurotransmitter
microbiota
imbalance,
central
sensitization,
heightening
stress
reactivity,
symptom
perception.
The
review
also
evaluates
family
dynamics
coping
exacerbating
FGID
contributing
conditions.
METHODS
A
narrative
was
conducted
using
328
studies
sourced
from
PubMed,
Scopus,
Google
Scholar,
covering
research
published
over
past
20
years.
Inclusion
criteria
focused
examining
diagnosis,
mechanisms,
comorbidities,
factors
pediatric
populations.
commonly
affecting
including
functional
constipation,
irritable
bowel
syndrome,
gastroesophageal
reflux,
cyclic
vomiting
were
analyzed
concerning
psychological
impacts.
RESULTS
highlights
a
strong
connection
between
symptoms,
mediated
by
dysregulated
sensitization.
physiological
disruptions
increase
children’s
vulnerability
while
-
early-life
trauma,
maladaptive
dynamics,
ineffective
intensify
cycle
distress.
CONCLUSION
Effective
requires
biopsychosocial
approach
integrating
medical,
psychological,
dietary
interventions.
Parental
education,
early
intervention,
multidisciplinary
care
coordination
critical
mitigating
long-term
improving
both
health
outcomes
FGIDs.
JMIR Formative Research,
Год журнала:
2025,
Номер
9, С. e72469 - e72469
Опубликована: Апрель 8, 2025
Abstract
Background
Maternal
mental
health
disorders
are
prevalent,
yet
many
individuals
do
not
receive
adequate
support
due
to
stigma,
financial
constraints,
and
limited
access
care.
Digital
interventions,
particularly
chatbots,
have
the
potential
provide
scalable,
low-cost
support,
but
few
tailored
specifically
needs
of
perinatal
individuals.
Objective
This
study
aimed
(1)
design
develop
Moment
for
Parents,
a
chatbot
education
(2)
assess
usability
through
engagement,
usage
patterns,
user
experience.
Methods
used
human-centered
rules-based
pregnant
postpartum
In
phase
1,
ethnographic
interviews
(n=43)
explored
inform
development.
2,
total
108
were
recruited
participate
in
pilot
test
had
unrestricted
chatbot.
Engagement
was
tracked
over
8
months
patterns
re-engagement
rates.
After
1
month,
participants
completed
usability,
relevance,
satisfaction
survey,
providing
key
insights
refining
Results
Key
themes
that
came
from
included
need
trusted
resources,
emotional
better
guidance.
These
informed
content,
including
mood-based
exercises
coping
strategies.
Re-engagement
high
(69/108,
63.9%),
meaning
users
who
stopped
interacting
at
least
week
returned
once.
A
large
proportion
(28/69,
40.6%)
re-engaged
3
or
more
times.
Overall,
28/30
(93.3%)
found
relevant
them,
though
some
noted
repetitive
content
response
options.
Conclusions
The
Parents
successfully
engaged
with
higher-than-typical
retention
patterns.
findings
underscore
importance
flexible,
digital
needs.
Future
research
should
examine
how
intermittent
use
influences
outcomes
refine
delivery
enhance
long-term
engagement
effectiveness.
The
journey
of
motherhood
encompasses
a
profound
array
emotions,
experiences,
and
challenges
that
extend
beyond
the
surface
joy
elation.
This
review
delves
into
crucial
yet
often
underexplored
realm
postpartum
mood
disorders,
aiming
to
illuminate
their
significance
foster
understanding.
Postpartum
including
depression,
anxiety
psychosis,
impact
mental
well-being
mothers
during
pivotal
phase
lives.
Through
comprehensive
exploration,
this
elucidates
various
dimensions
these
from
definitions
classifications
prevalence
on
both
families.
Identifying
diagnosing
disorders
is
discussed
in
detail,
shedding
light
emotional,
cognitive,
physical
symptoms
warrant
attention.
Screening
assessment
tools
are
highlighted
as
essential
instruments
for
early
detection,
while
diagnosis,
overlap
with
typical
experiences
influence
stigma,
explored.
further
treatment
intervention,
underscoring
importance
psychotherapy,
pharmacological
interventions,
individualised
plans.
roles
healthcare
providers
health
professionals
offering
support
guidance
emphasised,
emphasising
collaborative
approach.
Cultural
societal
influences
shaping
perceptions
health.
explores
how
can
create
barriers
seeking
help
highlights
destigmatising
disorders.
It
underscores
urgency
raising
awareness
fostering
supportive
environment
empowers
seek
assistance
without
fear
judgment.
Looking
toward
future,
points
potential
research
directions,
such
advances
understanding
hormonal
exploring
long-term
effects
maternal
overarching
call
action
resonates
-
increased
awareness,
support,
dismantling
stigma
imperative.
A
hopeful
vision
presented:
future
where
all
receive
appropriate
care,
no
mother
stands
alone
her
journey,
compassion
thrive.
BMC Pregnancy and Childbirth,
Год журнала:
2024,
Номер
24(1)
Опубликована: Июнь 14, 2024
Abstract
Background
Postpartum
depression
is
a
complex
mental
health
condition
that
often
occurs
after
childbirth
and
characterized
by
persistent
sadness,
anxiety,
fatigue.
Recent
research
suggests
metabolic
component
to
the
disorder.
This
study
aims
investigate
causal
relationship
between
blood
metabolites
postpartum
using
mendelian
randomization
(MR).
Methods
used
bi-directional
MR
framework
1,400
biomarkers
depression.
We
two
specific
genome-wide
association
studies
datasets:
one
with
single
nucleotide
polymorphisms
data
from
mothers
diagnosed
another
metabolite
data,
both
of
which
focused
on
people
European
ancestry.
Genetic
variants
were
chosen
as
instrumental
variables
datasets
strict
criteria
improve
robustness
analysis.
The
combination
these
enabled
thorough
examination
genetic
influences
profiles
associated
Statistical
analyses
conducted
techniques
such
inverse
variance
weighting,
weighted
median,
model-based
estimation,
rigorous
inference
observed
associations.
was
defined
endpoint
definitions
approved
FinnGen
study’s
clinical
expert
groups,
included
leading
experts
in
their
respective
medical
fields.
Results
analysis
identified
seven
could
be
linked
Out
these,
found
protective,
while
six
an
increased
risk
developing
condition.
results
consistent
across
multiple
methods,
indicating
significant
correlation.
Conclusions
emphasizes
potential
metabolomics
for
understanding
discovery
sheds
new
insights
its
pathophysiology
opens
up
possibilities
future
into
targeted
treatment
strategies.
This
comprehensive
review
delves
into
the
multifaceted
landscape
of
postpartum
depression
(PPD),
exploring
its
prevalence,
impact
on
maternal
and
infant
well-being,
efficacy
existing
screening
intervention
practices.
PPD
emerges
as
a
critical
concern,
with
implications
extending
beyond
individual
mental
health
to
encompass
dynamics
mother-infant
relationships
societal
well-being.
The
analysis
underscores
complexity
addressing
PPD,
emphasizing
challenges
associated
tools
importance
evidence-based
interventions.
A
call
action
resonates
throughout,
urging
healthcare
providers,
policymakers,
stakeholders
prioritize
support
for
new
mothers
through
enhanced
protocols
improved
accessibility
Furthermore,
highlights
need
destigmatization
awareness
campaigns
foster
supportive
environment.
Future
research
directions
are
outlined,
refinement
tools,
developing
innovative
interventions,
cultural
socioeconomic
influences
outcomes.
envisions
collaborative
effort
dispel
shadows
striving
future
where
receive
support,
ensuring
optimal
overall
Journal of Advanced Nursing,
Год журнала:
2024,
Номер
unknown
Опубликована: Май 10, 2024
Abstract
Aim
To
explore
the
experiences,
expectations
and
needs
of
mothers
from
low‐socioeconomic
status
at
1
month
postpartum.
Design
Descriptive
qualitative.
Methods
Mothers
irrespective
their
parity
were
invited
to
participate
in
one‐to‐one
interviews
Semi‐structured
conducted
until
data
saturation.
Interviews
audio
recorded,
transcribed
verbatim
analysed
thematically.
Written
informed
consent
was
obtained.
Results
Twenty
participated
six
themes
identified:
(1)
No
choice
but
find
meaning;
(2)
Father
as
a
major
pillar
support;
(3)
‘Kampung’
Spirit;
(4)
Trials
Tribulations
Transition
Motherhood;
(5)
Shame,
guilt
internalized
stigma
(6)
Reclaiming
power.
Conclusion
This
study
reflected
unique
struggles
with
pregnancy,
childbirth
early
postpartum
wider
health
inequities
within
Singapore's
maternal
system.
provide
much‐needed
support
improved
care,
stakeholders
government,
healthcare
providers
social
organizations
should
consider
niche
this
community.
Implications
for
Patient
Care
Nurses
need
reflect
on
own
biases
ensure
consistent
care
delivery
regardless
socioeconomic
status.
When
delivering
patient
education,
patient‐centred
sincere
advice
rooted
personal
experience
can
help
establish
rapport.
Impact
is
first
experiences
Singapore
context.
Low‐socioeconomic
experienced
less
autonomy
over
health,
they
received
childcare
options.
As
adjusted
new
roles,
struggled
cope.
However,
wary
surrounding
poverty
not
being
‘good
mother’,
preferred
seek
informal
family,
friends
self‐help
through
learning
media,
compared
formal,
external
help.
Reporting
Method
COREQ
checklist.
or
Public
Contribution
public
contribution.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(16), С. 8835 - 8835
Опубликована: Авг. 14, 2024
Postpartum
depression
(PPD)
affects
174
million
women
worldwide
and
is
characterized
by
profound
sadness,
anxiety,
irritability,
debilitating
fatigue,
which
disrupt
maternal
caregiving
the
mother–infant
relationship.
Limited
pharmacological
interventions
are
currently
available.
Our
understanding
of
neurobiological
pathophysiology
PPD
remains
incomplete,
potentially
hindering
development
novel
treatment
strategies.
Recent
hypotheses
suggest
that
driven
a
complex
interplay
hormonal
changes,
neurotransmitter
imbalances,
inflammation,
genetic
factors,
psychosocial
stressors,
hypothalamic–pituitary–adrenal
(HPA)
axis
dysregulation.
This
narrative
review
examines
recent
clinical
studies
on
within
past
15
years,
emphasizing
advancements
in
neuroimaging
findings
blood
biomarker
detection.
Additionally,
we
summarize
laboratory
work
using
animal
models
to
mimic
PPD,
focusing
hormone
withdrawal,
HPA
dysfunction,
perinatal
stress
theories.
We
also
revisit
results
from
several
brain
regions
associated
with
negative
emotions,
such
as
amygdala,
prefrontal
cortex,
hippocampus,
striatum.
These
insights
aim
improve
our
PPD’s
mechanisms,
guiding
future
research
for
better
early
detection,
prevention,
personalized
strategies
affected
their
families.
Frontiers in Global Women s Health,
Год журнала:
2025,
Номер
6
Опубликована: Апрель 9, 2025
Postpartum
depression
is
a
significant
global
health
challenge
that
affects
mothers,
infants,
and
families.
Although
various
preventive
strategies
show
promise,
comprehensive
reviews
evaluating
interventions
among
pregnant
women
without
clinical
diagnosis
of
remain
limited.
This
scoping
review
aims
to
identify
synthesize
the
existing
evidence
on
proactive
postpartum
prevention
programs
initiated
during
pregnancy.
Following
PRISMA
guidelines
for
reviews,
we
systematically
searched
PubMed
Scopus,
supplemented
by
manual
reference
reviews.
Our
search
strategy
combined
terms
related
depression,
pregnancy,
interventions.
Studies
were
included
if
they
evaluated
conducted
targeting
assessed
PPD
outcomes
using
established
diagnostic
criteria
or
validated
screening
tools.
Only
English-language
articles
published
between
2013
2023
considered.
A
total
49
studies
met
inclusion
criteria.
Interventions
categorized
into
nine
themes:
psychoeducation
(n
=
18),
home
visits
6),
cognitive
behavioral
therapy
(CBT)
mindfulness
exercise
4),
dietary
supplements
3),
interpersonal
(IPT)
consultation
1),
inhalation
aromatherapy
1).
Psychoeducational
mindfulness-based
consistently
reduce
risk,
particularly
when
delivered
in
structured,
theory-driven
formats
incorporating
family
support.
Digital
CBT
demonstrated
limited
effectiveness
due
lower
engagement,
while
home-visit
consultation-based
effective
integrated
maternal
healthcare
despite
scalability
challenges.
Exercise
supplement
yielded
inconsistent
outcomes,
indicating
factors
such
as
adherence,
duration,
intensity
are
crucial
determinants
effectiveness.
Various
available
prevent
PPD,
this
maps
different
used
their
outcomes.
Proactive,
theory-based,
multi-component
interventions,
psychoeducational
programs,
demonstrate
promising
potential.
Future
research
should
emphasize
long-term
optimizing
digital
engagement
strategies,
developing
culturally
tailored
models
enhance
accessibility
across
diverse
populations,
including
low-resource
settings.
Sensors,
Год журнала:
2024,
Номер
24(5), С. 1459 - 1459
Опубликована: Фев. 23, 2024
Postpartum
depression
(PPD)
is
a
serious
mental
health
issue
among
women
after
childbirth,
and
screening
systems
that
incorporate
questionnaires
have
been
utilized
to
screen
for
PPD.
These
are
sensitive
but
less
specific,
the
additional
use
of
objective
measures
could
be
helpful.
The
present
study
aimed
verify
usefulness
measure
autonomic
function,
heart
rate
variability
(HRV),
which
has
reported
dysregulated
in
people
with
depression.
Among
935
who
had
experienced
childbirth
completed
Edinburgh
Postnatal
Depression
Scale
(EPDS),
HRV
was
measured
EPDS-positive
(n
=
45)
1
4
weeks
using
wearable
device.
measurement
based
on
three-behavioral-state
paradigm
5
min
duration,
consisting
rest
(Rest),
task
load
(Task),
rest-after-task
(After)
states,
low-frequency
power
(LF),
high-frequency
(HF),
their
ratio
(LF/HF)
were
calculated.
included
this
study,
12
diagnosed
PPD
33
adjustment
disorder
(AJD).
Women
showed
lack
adequate
regulation
response
load,
accompanying
high
LF/HF
score
Rest
state.
On
other
hand,
AJD
exhibited
HF
reduced
during
After
A
linear
discriminant
analysis
indices
(HR)
revealed
both
differentiation
patients
from
controls
possible.
sensitivity
specificity
vs.
75.0%
90.9%,
respectively.
Using
paradigm,
an
characteristic
profiles
AJD,
suggesting
it
may
serve
as
point-of-care
sensing
tool
systems.