Nanoparticles of Natural Product-derived Medicines: Beyond the Pandemic
Heliyon,
Год журнала:
2025,
Номер
11(4), С. e42739 - e42739
Опубликована: Фев. 1, 2025
This
review
explores
the
synergistic
potential
of
natural
products
and
nanotechnology
for
viral
infections,
highlighting
key
antiviral,
immunomodulatory,
antioxidant
properties
to
combat
pandemics
caused
by
highly
infectious
viruses.
These
often
result
in
severe
public
health
crises,
particularly
affecting
vulnerable
populations
due
respiratory
complications
increased
mortality
rates.
A
cytokine
storm
is
initiated
when
an
overload
pro-inflammatory
cytokines
chemokines
released,
leading
a
systemic
inflammatory
response.
Viral
mutations
limited
availability
effective
drugs,
vaccines,
therapies
contribute
continuous
transmission
virus.
The
coronavirus
disease-19
(COVID-19)
pandemic
has
sparked
renewed
interest
product-derived
antivirals.
efficacy
traditional
medicines
against
infections
examined.
Their
anti-inflammatory,
are
highlighted.
discusses
how
enhances
herbal
combating
infections.
Язык: Английский
AICpred: Machine Learning-Based Prediction of Potential Anti-Inflammatory Compounds Targeting TLR4-MyD88 Binding Mechanism
Information,
Год журнала:
2025,
Номер
16(1), С. 34 - 34
Опубликована: Янв. 7, 2025
Toll-like
receptor
4
(TLR4)
has
been
implicated
in
the
production
of
uncontrolled
inflammation
within
body,
known
as
cytokine
storm.
Studies
that
employ
machine
learning
(ML)
prediction
potential
inhibitors
TLR4
are
limited.
This
study
introduces
AICpred,
a
robust,
free,
user-friendly,
and
easily
accessible
learning-based
web
application
for
predicting
against
by
targeting
TLR4-myeloid
differentiation
primary
response
88
(MyD88)
interaction.
MyD88
is
crucial
adaptor
protein
TLR4-induced
hyper-inflammation
pathway.
Predictive
models
were
trained
using
random
forest,
adaptive
boosting
(AdaBoost),
eXtreme
gradient
(XGBoost),
k-nearest
neighbours
(KNN),
decision
tree
models.
To
handle
imbalance
training
data,
resampling
techniques
such
under-sampling,
synthetic
minority
oversampling
technique,
selection
5000
instances
majority
class
employed.
A
10-fold
cross-validation
strategy
was
used
to
evaluate
model
performance
based
on
metrics
including
accuracy,
balanced
recall.
The
XGBoost
demonstrated
superior
with
recall
scores
0.994,
0.958,
0.917,
respectively,
test.
AdaBoost
also
excelled
accuracies
ranging
from
0.981
0.992,
between
0.921
0.944,
0.845
0.891
both
test
datasets.
deployed
AICpred
screen
compounds
have
reported
positive
effects
mitigating
hyperinflammation-associated
storm,
which
key
factor
COVID-19.
predicted
Baricitinib,
Ibrutinib,
Nezulcitinib,
MCC950,
Acalabrutinib
anti-TLR4
probability
above
0.90.
Additionally,
inhibit
TLR4,
TAK-242
(Resatorvid)
benzisothiazole
derivative
(M62812),
bioactive
agents
applicability
domain
probabilities
0.80.
Computationally
inferred
can
be
explored
starting
skeletons
therapeutic
hyperinflammation.
These
predictions
must
consolidated
experimental
screening
enhance
further
optimisation
compounds.
first
its
kind
inhibition
TLR4-MyD88
binding
freely
available
at
http://197.255.126.13:8080.
Язык: Английский
Immunological Disorders: Gradations and the Current Approach in Laboratory Diagnostics
Pathophysiology,
Год журнала:
2025,
Номер
32(2), С. 17 - 17
Опубликована: Апрель 18, 2025
Currently,
understanding
the
immune
response,
its
abnormalities,
and
diagnostic
possibilities
is
a
key
point
in
management
of
patients
with
various
diseases,
from
infectious
to
oncological
ones.
The
aim
this
review
was
analyze
data
presented
current
literature
on
disorders
possibility
their
laboratory
diagnostics
combination
clinical
manifestations.
We
have
performed
systematic
analysis
international
databases
over
last
ten
years.
diagnosing
immunopathological
processes
due
changes
cells
soluble
molecules
involved
pathogenesis
wide
range
as
well
determination
antibodies
detect
autoimmune
processes.
By
applying
techniques
such
hematology,
flow
cytometry,
ELISA,
etc.,
available
most
laboratories
worldwide,
system
dysfunction
diseases
are
being
collected.
This
process
unfortunately
still
very
far
completed.
However,
all
diversity
accumulated
knowledge,
we
can
currently
state
that
vast
majority
immune-mediated
not
yet
known.
At
same
time,
success
dividing
into
distinct
clusters
based
different
types
inflammatory
responses
involvement
populations
T
helper
cytokine
represents
significant
progress.
Further
research
direction
seems
promising,
it
allows
identification
new
target
for
both
improved
targeted
therapies.
Язык: Английский
Role of Flavonoids in Sepsis: Advances and Future Prospects
Sara Osman Esmail,
Ahmed Zorin Sahlan
Опубликована: Май 20, 2024
Due
to
the
host
immunological
disease
brought
on
by
infection
is
sepsis,
multiple
organ
dysfunction
syndrome
(MODS),
which
has
a
high
morbidity
and
mortality
rate,
could
be
result.
With
advances
in
pathogen
detection
technologies,
breakthroughs
anti-infection
drugs,
creation
of
function
support,
clinical
diagnosis
treatment
sepsis
have
advanced
significantly.
Pathogen-induced
abnormal
responses,
can
range
from
excessive
inflammation
immunosuppression,
are
recognized
play
significant
role
death
rate.
Unfortunately,
no
medications
that
specifically
intended
treat
been
licensed.
In
order
offer
theoretical
foundation
for
management
we
will
now
discuss
current
advancements
research
responses
sepsis.
The
prognosis
patients
may
improved
developing
optimizing
dynamic
immune
system
plan
based
therapy,
fluid
replacement,
support
function,
timely
application
immunomodulatory
therapies
Язык: Английский
Clostridium ramosum alone caused Fournier's gangrene in an older Chinese patient with abnormal interleukin levels: A rare case report
Heliyon,
Год журнала:
2024,
Номер
10(12), С. e33244 - e33244
Опубликована: Июнь 1, 2024
is
an
uncommon
Clostridium
but
one
of
the
essential
anaerobic
bacteria
that
makes
up
intestinal
microbiota.
A
highly
variable
body
temperature,
white
blood
cell
count,
or
elusory
prognosis
can
reflect
Язык: Английский
Mesenchymal Stem Cells and Their Extracellular Vesicles Are a Promising Alternative to Antibiotics for Treating Sepsis
Bioengineering,
Год журнала:
2024,
Номер
11(11), С. 1160 - 1160
Опубликована: Ноя. 18, 2024
Sepsis
is
a
life-threatening
disease
caused
by
the
overwhelming
response
to
pathogen
infections.
Currently,
treatment
options
for
sepsis
are
limited
broad-spectrum
antibiotics
and
supportive
care.
However,
growing
resistance
of
pathogens
common
complicates
efforts.
Excessive
immune
(i.e.,
cytokine
storm)
can
persist
even
after
infection
cleared.
This
overactive
inflammatory
severely
damage
multiple
organ
systems.
Given
these
challenges,
managing
excessive
critical
in
controlling
progression.
Therefore,
Mesenchymal
stem
cells
(MSCs),
with
their
immunomodulatory
antibacterial
properties,
have
emerged
as
promising
option
adjunctive
therapy
treating
sepsis.
Moreover,
MSCs
exhibit
favorable
safety
profile,
they
eventually
eliminated
host's
system
within
several
months
post-administration,
resulting
minimal
side
effects
not
been
linked
antibiotic
drawbacks
resistance).
review
explores
potential
personalized
treatment,
clarifying
mechanisms
action
providing
up-to-date
technological
advancements
enhance
protective
efficacy
patients
suffering
from
its
consequences.
Язык: Английский