NT-proBNP in Acute De Novo Heart Failure: A Key Biomarker for Predicting Myocardial Recovery—COMFE Registry
Life,
Год журнала:
2025,
Номер
15(4), С. 526 - 526
Опубликована: Март 23, 2025
This
study
aims
to
analyze
whether
NT-proBNP
at
admission
and
discharge
in
de
novo
heart
failure
(HF)
with
reduced
ejection
fraction
(HFrEF)
is
associated
myocardial
recovery.
a
prospective
observational
two
centers.
Patients
admitted
HFrEF
between
2021
2023
were
included.
HF
improved
(HFimpEF)
was
defined
as
an
improvement
of
least
10
points
>40%.
Of
the
248
patients
who
included,
63.3%
met
HFimpEF
criteria
follow-up,
no
differences
age
or
gender.
There
admission,
but
there
discharge,
where
its
value
inversely
recovery
(OR
0.99
for
each
increase
square
root
NT-proBNP,
95%
CI
0.98–0.99,
p
=
0.048).
An
>
10,000
pg/mL
independently
ventricular
0.28,
0.07–0.94,
0.043).
A
smaller
reduction
during
decreased
probability
0.13,
0.03–0.61,
0.010).
In
conclusion,
admissions
HFrEF,
recovery;
level
independent
predictor
lack
recovery,
while
greater
increases
likelihood
Язык: Английский
Circulating Cell-Free Nuclear DNAs Predicted an Improvement of Systolic Left Ventricular Function in Individuals with Chronic Heart Failure with Reduced Ejection Fraction
Опубликована: Авг. 29, 2024
Patients
with
heart
failure
(HF)
improved
LVEF
(HFimpEF)
demonstrate
better
clinical
outcomes
when
compared
individuals
without
restoration
of
cardiac
function.
Identification
predictors
for
HFimpEF
may
play
a
crucial
role
in
individual
management
HF
reduced
EF
(HFrEF).
Cell-free
nuclear
(cf-nDNA)
DNA
are
released
from
damaged
cells
and
contribute
to
adverse
remodeling,
dysfunction
inflammation.
The
purpose
the
study
was
elucidate
whether
cf-nDNAs
associated
HFimpEF.
It
has
been
prescreened
1416
patients
using
local
database.
Between
October
2021
August
2022
we
included
452
chronic
HFrEF
after
prescription
optimal
guideline-based
therapy
identified
177
them
according
criteria
European
Society
Cardiology.
Measurements
circulating
biomarkers
were
performed
at
baseline
6
months.
Detection
cf-nDNA
executed
real
time
quantitative
PCR
(qPCR)
NADH
dehydrogenase,
ND2
beta-2-microglobulin.
We
found
that
significant
decrease
levels
persistent
cohort.
Presence
ischemia-induced
cardiomyopathy
(odds
ration
[OR]
=
0.75;
confidence
interval
[CI]
0.62
–
0.88;
p
0.044),
type
2
diabetes
mellitus
(OR
0.77;
CI
0.71
0.82;
0.042)
digoxin
administration
0.85;
0.72-0.97;
negative
factors
HFimpEF,
whereas
NT-proBNP
≤1940
pmol/mL
1.42;
95%
1.19-1.98,
0.001),
relative
(>35%
vs.
≤35%)
1.52;
1.38-0.69,
0.001)
≤7.5
μmol/L
1.56;
1.07-2.94,
positive
Multivariate
logistic
regression
adjusted
cardiomyopathy,
IV
NYHA
class,
use
yielded
1.43;
1.21-1.88,
1.64;
1.19-2.15,
independently
predicted
In
conclusions:
established
cf-nDNA≤7.5
discriminative
ability
as
single
measured
well
≤35%
baseline.
Язык: Английский
Circulating Cell-Free Nuclear DNA Predicted an Improvement of Systolic Left Ventricular Function in Individuals with Chronic Heart Failure with Reduced Ejection Fraction
Cardiogenetics,
Год журнала:
2024,
Номер
14(4), С. 183 - 197
Опубликована: Окт. 1, 2024
Background:
Patients
with
heart
failure
(HF)
improved
ejection
fraction
(HFimpEF)
demonstrate
better
clinical
outcomes
when
compared
individuals
without
restoration
of
cardiac
function.
The
identification
predictors
for
HFimpEF
may
play
a
crucial
role
in
the
individual
management
HF
reduced
(HFrEF).
Cell-free
nuclear
(cf-nDNA)
DNA
is
released
from
damaged
cells
and
contributes
to
impaired
structure
function
inflammation.
purpose
study
was
elucidate
whether
cf-nDNA
associated
HFimpEF.
Methods:
prescreened
1416
patients
using
local
database.
Between
October
2021
August
2022,
we
included
452
chronic
HFrEF
after
prescription
optimal
guideline-based
therapy
identified
177
individuals.
Circulating
biomarkers
were
measured
at
baseline
6
months.
Detection
executed
real-time
quantitative
PCR
(qPCR)
NADH
dehydrogenase,
ND2,
beta-2-microglobulin.
Results:
We
found
that
significant
decrease
levels
persistent
cohort.
presence
ischemia-induced
cardiomyopathy
(odds
ration
[OR]
=
0.75;
p
0.044),
type
2
diabetes
mellitus
(OR
0.77;
0.042),
digoxin
administration
0.85;
0.042)
negative
factors
HFimpEF,
whereas
NT-proBNP
≤
1940
pmol/mL
1.42,
0.001),
relative
(>35%
vs.
≤35%)
1.52;
7.5
μmol/L
1.56;
0.001)
positive
Conclusions:
established
independently
predicted
discriminative
ability
cardiomyopathy,
IV
NYHA
class,
single-measured
led
≤35%
HFrEF.
Язык: Английский
Exploring the Relationship Between Ejection Fraction, Arterial Stiffness, NT-proBNP, and Hospitalization Risk in Heart Failure Patients
Diagnostics,
Год журнала:
2024,
Номер
14(24), С. 2885 - 2885
Опубликована: Дек. 22, 2024
Background/Objectives:
Heart
failure
(HF)
remains
a
leading
cause
of
hospitalization
and
morbidity.
Arterial
stiffness,
measured
by
pulse
wave
velocity
(PWV)
the
augmentation
index
(AIx),
has
been
linked
to
HF
severity
prognosis.
This
study
investigates
relationship
between
clinical
parameters,
biochemical
indicators,
arterial
stiffness
in
hospitalized
patients
with
HF,
aiming
identify
predictors
improve
patient
management.
Methods:
cross-sectional
included
98
admitted
HF:
53
acutely
decompensated
(sudden
worsening
symptoms)
45
chronic
(stable
symptoms
HF).
Clinical
including
ejection
fraction
(EF),
N-terminal
prohormone
brain
natriuretic
peptide
(NT-proBNP)
levels,
indicators
(PWV
AIx),
were
at
admission.
During
follow-up,
59
required
re-hospitalization
due
while
39
remained
outpatients
without
further
hospitalization.
The
these
parameters
was
analyzed
using
Pearson
correlation
coefficients,
multiple
Cox
regression
analysis
conducted
independent
re-hospitalization.
Results:
A
significant
negative
EF
PWV
found
(r
=
−0.853,
95%
CI
[−0.910,
−0.764]),
suggesting
an
association
improved
heart
function
(higher
EF)
reduced
(lower
PWV).
moderate
positive
AIx
0.626,
[0.473,
0.805])
suggests
that,
higher
is
associated
increased
AIx,
weaker
compared
PWV.
may
reflect
differing
contributions
vascular
myocardial
factors
severity.
Hospitalized
exhibited
significantly
poorer
profiles,
NT-proBNP
levels
(p
<
0.001)
worse
blood
pressure
(BP)
measurements
(systolic
diastolic,
p
0.01).
Multiple
identified
PWV,
Aix,
as
patients,
hazard
ratios:
(HR
1.15,
0.02),
1.03,
1.0001,
Conclusions:
indices
EF,
patients.
These
findings
suggest
that
integrating
into
routine
assessments
enhance
risk
stratification
inform
targeted
interventions
reduce
hospitalizations
outcomes.
Язык: Английский
Characteristics and Outcomes of Heart Failure Outpatients with Improvement in Ejection Fraction in Qatar
Heart Views,
Год журнала:
2024,
Номер
25(3), С. 117 - 126
Опубликована: Июль 1, 2024
Introduction:
Heart
failure
with
reduced
ejection
fraction
(HFrEF)
in
Qatar
has
not
been
well
characterized
the
outpatient
setting.
Objective:
To
describe
characteristics
of
patients
HFrEF
who
had
improvement
their
left
ventricular
(LVEF)
and
independent
predictors
improvement.
Methods:
This
retrospective
cohort
study
conducted
at
advanced
heart
(HF)
clinic
recruited
visited
between
January
2017
December
2018.
Adult
were
eligible
if
they
diagnosed
(LVEF
<
40%)
two
echocardiograms
separated
by
least
6
months.
Results:
Of
582
patients,
161
(27.7%)
improved
LVEF.
They
younger
(53.4
vs.
57.3
years,
P
=
0.002)
shorter
duration
HF
diagnosis
(4.3
5.6
0.001).
experienced
lower
rates
all-cause
hospitalization
(20.5%
38.0%,
0.001)
emergency
department
visits
(25.5%
35.9%,
0.001),
without
a
difference
hospital
mortality
rate,
than
those
LVEF
Decreased
odds
ratio
was
associated
per
year
increase
age
(adjusted
[aOR]:
0.98,
95%
confidence
interval
[CI]:
0.97–0.99,
0.03),
presence
bundle
branch
block
(aOR:
0.40,
CI:
0.20–0.80,
0.85,
0.78–0.94,
ischemic
etiology
0.50,
0.30–0.77,
0.001;
compared
dilated
etiology).
Beta-blocker
therapy
higher
2.65,
1.02–6.88,
Conclusion:
Patients
younger,
nonischemic
cardiomyopathy,
significantly
fewer
hospitalizations
visits.
Язык: Английский