Neutral Polysaccharide from Platycodonis Radix-Ameliorated PM2.5-Induced Lung Injury by Inhibiting the TLR4/NF-κB p65 Pathway and Regulating the Lung and Gut Microbiome DOI

Yang Sun,

Yanchun Wang, Z.F. Yang

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(50), С. 27923 - 27938

Опубликована: Дек. 3, 2024

Platycodonis radix (PR) has been reported to play a protective role in lung injury. However, much less is known about the effect and mechanism of its main component PR polysaccharides (PRPs) particulate matter (PM2.5)-induced Here, neutral polysaccharide (MW: 244.56 kDa) was isolated from PR, mainly composed Rha, Ara, Gal, Glc, Xyl, Man. PRPs significantly improved PM2.5-induced pulmonary edema, oxidative damage, cell apoptosis downregulated inflammatory factor levels bronchoalveolar lavage fluid. Mechanistically, reduced intestinal mucosal barrier thereby lowering serum lipopolysaccharide inhibiting overactivation TLR4/NF-κB signaling pathway tissue. Notably, could optimize composition microbiota. Oral administration resulted enrichment short-chain fatty acid (SCFA)-producing bacteria, upregulating acetate, butyrate, isovalerate. Taken together, have great potential preventing repairing injury caused by PM2.5.

Язык: Английский

Neutral Polysaccharide from Platycodonis Radix-Ameliorated PM2.5-Induced Lung Injury by Inhibiting the TLR4/NF-κB p65 Pathway and Regulating the Lung and Gut Microbiome DOI

Yang Sun,

Yanchun Wang, Z.F. Yang

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(50), С. 27923 - 27938

Опубликована: Дек. 3, 2024

Platycodonis radix (PR) has been reported to play a protective role in lung injury. However, much less is known about the effect and mechanism of its main component PR polysaccharides (PRPs) particulate matter (PM2.5)-induced Here, neutral polysaccharide (MW: 244.56 kDa) was isolated from PR, mainly composed Rha, Ara, Gal, Glc, Xyl, Man. PRPs significantly improved PM2.5-induced pulmonary edema, oxidative damage, cell apoptosis downregulated inflammatory factor levels bronchoalveolar lavage fluid. Mechanistically, reduced intestinal mucosal barrier thereby lowering serum lipopolysaccharide inhibiting overactivation TLR4/NF-κB signaling pathway tissue. Notably, could optimize composition microbiota. Oral administration resulted enrichment short-chain fatty acid (SCFA)-producing bacteria, upregulating acetate, butyrate, isovalerate. Taken together, have great potential preventing repairing injury caused by PM2.5.

Язык: Английский

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