Plasma Bacterial Metabolites in Crohn’s Disease Pathogenesis and Complications DOI Open Access
Anna Deskur, Filip Ambrożkiewicz, Emilia Samborowska

и другие.

Nutrients, Год журнала: 2024, Номер 17(1), С. 74 - 74

Опубликована: Дек. 28, 2024

Background/Objectives: Crohn’s disease is known for being associated with an abnormal composition of the bacterial flora, dysbiosis and intestinal function disorders. Metabolites produced by gut microbiota play a pivotal role in pathogenesis CD, presence unspecific extraintestinal manifestations. Methods: The aim this study was determination level metabolites blood plasma patients disease. CD (29) healthy individuals (30) were recruited study. Bacterial (SCFAs TMAO panel) measured liquid chromatography–mass spectrometry system. Results: A significant correlation (p-value < 0.05) between obtained three eight tested SCFAs; acetic acid (reduced CD; FC 1.7; AUC = 0.714), butyric (increased; 0.68; 0.717), 2MeBA (FC 1.168; 0.702), indoxyl 0.624). concentration CA 0.82) choline 0.78) significantly disturbed according to biological treatment. Choline 1.28) also treated glucocorticoids. In total, 68.97% presented manifestations (EIMs) disease, mainly osteoarticular complications. BA statistically elevated 0.602) manifestations, while group complications, difference betaine 1.647) observed. Conclusions: analyzed may help diagnostic process, monitoring course treatment, lowly invasive way, as biomarkers after additional research on larger patients.

Язык: Английский

Plasma Bacterial Metabolites in Crohn’s Disease Pathogenesis and Complications DOI Open Access
Anna Deskur, Filip Ambrożkiewicz, Emilia Samborowska

и другие.

Nutrients, Год журнала: 2024, Номер 17(1), С. 74 - 74

Опубликована: Дек. 28, 2024

Background/Objectives: Crohn’s disease is known for being associated with an abnormal composition of the bacterial flora, dysbiosis and intestinal function disorders. Metabolites produced by gut microbiota play a pivotal role in pathogenesis CD, presence unspecific extraintestinal manifestations. Methods: The aim this study was determination level metabolites blood plasma patients disease. CD (29) healthy individuals (30) were recruited study. Bacterial (SCFAs TMAO panel) measured liquid chromatography–mass spectrometry system. Results: A significant correlation (p-value < 0.05) between obtained three eight tested SCFAs; acetic acid (reduced CD; FC 1.7; AUC = 0.714), butyric (increased; 0.68; 0.717), 2MeBA (FC 1.168; 0.702), indoxyl 0.624). concentration CA 0.82) choline 0.78) significantly disturbed according to biological treatment. Choline 1.28) also treated glucocorticoids. In total, 68.97% presented manifestations (EIMs) disease, mainly osteoarticular complications. BA statistically elevated 0.602) manifestations, while group complications, difference betaine 1.647) observed. Conclusions: analyzed may help diagnostic process, monitoring course treatment, lowly invasive way, as biomarkers after additional research on larger patients.

Язык: Английский

Процитировано

0