An Updated Comprehensive Review on Novel Drug Delivery Systems (NDDS) In the Pharmaceuticals
Asian Journal of Pharmaceutical Research and Development,
Год журнала:
2024,
Номер
12(1), С. 55 - 64
Опубликована: Фев. 15, 2024
The
field
of
pharmaceutical
sciences
has
witnessed
a
paradigm
shift
with
the
advent
Novel
Drug
Delivery
Systems
(NDDS),
which
aim
to
enhance
therapeutic
efficacy,
reduce
side
effects,
and
improve
patient
compliance.
This
comprehensive
review
explores
latest
advancements
innovations
in
NDDS,
encompassing
diverse
range
delivery
platforms
strategies.(NDDs
are
transforming
landscape
treatment,
offering
unparalleled
potential
for
enhanced
improved
bioavailability,
controlled
release,
targeted
delivery,
stability.
highlighting
recent
addressing
key
challenges.
Prominent
NDDS
include
liposomes,
nanoparticles,
micelles,
polymeric
drug
conjugates,
monoclonal
antibodies,
implants,
patches.
Each
system
possesses
unique
properties
applications,
tailored
specific
drugs
needs.
Recent
breakthroughs
nanocarriers,
gene
therapy
vectors,
3D-printed
personalized
dosage
forms
pushing
boundaries
innovation.
main
highlights
present
firstly
basics
on
NDDs,
several
approaches
nano
carriers
their
preparation
methods
example.
middle
version
discuss
techniques
NDDs
lastly
marketed
formulation
particular
carrier.
Язык: Английский
The Design and Optimization of Fast-dissolving Oral Drug Delivery System (ODDS) of Valproic Acid (VLA) an Anti-epileptic Category Drug
Devanand Jha,
Gagan Kumar Utwaliya,
K. Bhavya Sindhu
и другие.
Advances in Research,
Год журнала:
2024,
Номер
25(2), С. 152 - 166
Опубликована: Фев. 28, 2024
Objective:
Develop
and
optimize
a
fast-dissolving
oral
drug
delivery
system
(ODDS)
for
Valproic
acid
(VLA),
an
anti-epileptic
drug,
using
Design
of
Experiments
(DoE).
Methodology:
DoE,
powerful
tool
optimizing
formulations,
was
employed
to
investigate
the
impact
various
factors
on
dissolution
rate
VLA
ODDS.
Key
studied
included
superdisintegrants
(sodium
starch
glycolate,
crospovidone),
diluents
(lactose,
microcrystalline
cellulose),
lubricants
(magnesium
stearate).
A
Box-Behnken
design
used
create
experimental
runs,
at
30
minutes
chosen
as
response
variable.
Results:
The
DoE
analysis
revealed
significant
interactions
between
affecting
rate.
formulation
containing
sodium
lactose,
low
magnesium
stearate
concentration
exhibited
fastest
(Q30
>
85%
in
10
minutes).
Conclusion:
This
study
successfully
designed
optimized
ODDS
DoE.
offered
rapid
release,
potentially
improving
patient
compliance
therapeutic
efficacy.
approach
demonstrates
effectiveness
pharmaceutical
formulations
enhanced
performance.
findings
indicated
that
RSM
effectively
utilized
developing
valproic
fast
dispersible
tablets,
thus
representing
progress
treatment
epileptic
seizures.
Язык: Английский