На основании анализа данных литературы изложены современные представления об изменениях функционирования эндокринной регуляции, происходящих под влиянием различных факторов внешней среды. Показано, что гипоталамо-гипофизарно-гонадная и тиреоидная ось эндокринной регуляции наряду с симпатоадреналовым и гипоталамо-гипофизарно-надпочечниковым звеном играют важнейшую роль в ответ на экстремальные воздействия внешней среды и адаптацию организма. При этом в механизмах поддержания гомеостаза организма изменения гормональной секреции представляют собой своеобразный каскад тесно взаимосвязанных реакций. Изучение этих механизмов и выяснение их роли в патогенезе вызываемых нарушений — фундаментальная проблема биомедицинских исследований. Ее решение позволит совершенствовать способы профилактики и лечения заболеваний, обусловленных стрессом.
Ukraïnsʹkij žurnal medicini bìologìï ta sportu,
Год журнала:
2021,
Номер
6(4), С. 172 - 178
Опубликована: Сен. 20, 2021
In
some
northern
regions
of
Ukraine
there
is
an
increased
accumulation
salts
heavy
metals
in
soil
and
drinking
water,
which
negatively
affect
the
health
population
become
a
risk
factor
for
many
diseases.
The
role
pituitary
gland
regulation
functional
disorders
hormonal
homeostasis
various
pathological
conditions
extremely
important.
purpose
study
to
morphological,
morphometric
biochemical
rearrangements
structural
components
adenohypophysis
adult
male
rats
under
long-term
exposure
metals.
Materials
methods.
experiment
was
performed
on
24
white
rats,
were
divided
into
1
control
experimental
group.
group
consisted
90
days
consumed
ordinary
saturated
with
combination
metals:
zinc
(ZnSO4
·
7H2O)
–
5
mg/l,
copper
(CuSO4
5H2O)
iron
(FeSO4)
10
manganese
(MnSO4
0.1
lead
(Pb
(NO3)
2)
mg/l
chromium
(K2Cr2O7)
mg/l.
Results
discussion.
Long-term
effects
body
animals
caused
pronounced
compensatory-adaptive
changes
hypoxic
nature.
Morphological
organ
accompanied
by
plethora
venous
bed,
deterioration
rheological
properties
blood,
increase
area
connective
tissue
component
gland,
violation
histoarchitectonics
epithelial
trabeculae,
edema
parenchyma,
linear
indicators
gland.
Toxic
affected
cellular
composition
adenohypophysis:
number
chromophobes
decrease
chromophilic
acidophiles
basophils
compared
animals.
At
same
time,
parameters,
nuclei
cytoplasm
adenocytes
can
be
attributed
both
their
compensatory
hypertrophy
due
processes
deepening
impaired
blood
flow
from
as
result
plethora.
Conclusion.
Morphometric
parameters
anterior
lobe
at
metals,
course,
indicate
significant
stress
adaptive
response
stressors
(salts
metals)
Fizioterapevt (Physiotherapist),
Год журнала:
2023,
Номер
5, С. 33 - 40
Опубликована: Окт. 11, 2023
Relevance.
Adenomyosis
(or
endometriosis)
is
a
common
and
intractable
disease,
which,
according
to
various
studies,
affects
up
45
%
of
women
reproductive
age
worldwide
often
aggravated
by
the
presence
chronic
pelvic
pain
leading
development
psycho-emotional
disorders.
Objective:
To
study
effect
complex
treatment,
including
ozone
therapy,
on
emotional
stress
in
with
diffuse
adenomyosis
stage
II.
Subject
methods.
An
open
randomized
controlled
was
conducted
40
II
aged
32.5
±
9.4
years,
who
were
divided
into
two
groups.
Group
1
(control,
n
=
10)
received
standard
drug
therapy;
group
2
(main
group,
30)
additional
therapy.
The
effectiveness
treatment
assessed
using
VAS
scale
MH
component
SF-36
questionnaire,
as
well
statistical
analysis
before
after
1,
3
6
months
follow-up.
Results
discussion.
Before
start
patients
both
groups
showed
significant
differences
compared
norm,
which
confirmed
deterioration
their
socio-psychological
status,
severe
pain.
After
course
2nd
(main)
score
components
tended
physiological
norm.
At
same
time,
statistically
strong
inverse
correlation
between
scores
revealed.
In
1st
(control)
studied
parameters
changed
little
during
evidence
insufficient
analgesic
therapy
high
level
neuropsychic
distress
instability
these
patients.
Conclusion.
inclusion
for
contributed
decrease
severity
symptoms
mental
trauma.
addition,
trend
line
indicator
MN
its
normal
values,
indicated
positive
forecast
more
future
periods.
only
no
improvement
observed.
