Опубликована Янв. 1, 2015

The NeuN protein is localized in nuclei and perinuclear cytoplasm of most of the neurons in the central nervous system of mammals. Monoclonal antibodies to the NeuN protein have been actively used in the immunohistochemical research of neuronal differentiation to assess the functional state of neurons in norm and pathology for more than 20 years. Recently, NeuN antibodies have begun to be applied in the differential morphological diagnosis of cancer. However, the structure of the protein, which can be revealed by antibodies to NeuN, remained unknown until recently, and the functions of the protein are still not fully clear. In …

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Опубликована Янв. 1, 2014

Precise studies of plant, animal and human genomes enable remarkable opportunities of obtained data application in biotechnology and medicine. However, knowing nucleotide sequences isn’t enough for understanding of particular genomic elements functional relationship and their role in phenotype formation and disease pathogenesis. In post-genomic era methods allowing genomic DNA sequences manipulation, visualization and regulation of gene expression are rapidly evolving. Though, there are few methods, that meet high standards of efficiency, safety and accessibility for a wide range of researchers. In 2011 and 2013 novel methods of genome editing appeared - this are TALEN (Transcription Activator-Like Effector Nucleases) and CRISPR …

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Опубликована Янв. 1, 2015

Senescence has been the focus of research for many centuries. Despite significant progress in extending average human life expectancy, the process of aging remains largely elusive and, unfortunately, inevitable. In this review, we attempted to summarize the current theories of aging and the approaches to understanding it.

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Опубликована Янв. 1, 2020

Due to a number of negative events for the Russian economy, the process of digitaliza-tion and implementation of financial technology (fintech) may become the main com-petitive advantages to determine the growth prospects of the banking business of Russia in the short and medium term. In addition to projects implemented with the support of the government and the Bank of Russia, large Russian banks are currently investing heavily in fintech and are actively implementing innovative pilot projects. The article reveals the key technologies of digital transformation in Russia are technologies such as Big Data and predictive analytics, artificial intelligence, robotics, machine …

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Опубликована Янв. 1, 2020

Agriculture is one of the most important priority sectors of the national economy, which provides the country's foodsecurity. But there are many problems in the activ-ities of agricultural producers, connected to the general taxation regime and the large tax burden.The purpose of this article is to study the current Unified Agricultural Tax (UAT), identify the positive and negative aspects of the application of these special tax re-gimes, as well as identify the main instruments of state support for agricultural pro-ducers.The problems that were solved during the writing these work were to substantiate the feasibility of Unified Agricultural Tax introduction for …

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Опубликована Янв. 1, 2015

The article describes the etiologic role of various factors such as chronic rheumatic heart disease, bacterial endocarditis, aortic valve stenosis, hypertension, coronary heart disease, including acute myocardial infarction, degenerative disease of the valves, connective tissue diseases, chest trauma, sys-temic lupus erythematosus, con-genital heart disease which leading to the mitral valve chords rupture, gives the current classification of the nosology and also features of manifestation and clinical course. The authors also described a clinical case of mitral valve posterior leaflet chord rupture in the patient with hypertension, ischemic heart disease and chronic obstructive pulmonary disease, which reflects all the stages of …

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Опубликована Янв. 1, 2016

In the conditions of introduction of the proper practice of production of medicinal facilities on pharmaceutical enterprises in Ukraine, it is necessary to develop effective measures of projects management for creation of favourable conditions for modernisation of pharmaceutical production, innovative management and management of development projects. The optimization of pharmaceutical production of injection preparations, modernisation of the pharmaceutical industries, is being implemented in accordance with the standards of GM. Risks-control of pharmaceutical production of hi-tech parenteral preparations on a new level is carried out at the following stages: preparation of raw material, preparation of facilities and equipment; the process of …

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Опубликована Дек. 14, 2017

Simultaneous interpreting (SI) is difficult to reduce to an efficient and ecologically valid experimental paradigm allowing the measurement of working memory (WM) and attention — key components of all cognitive models of SI. These models could be validated and further refined in light of electrophysiological evidence. Here we propose a novel method for estimating WM load and report the results of our electroencephalographic study that lend support to the prediction of the Efforts Model of SI (Gile, 1988). In particular, this model predicts that increased WM load impairs the processing of auditory stimuli. Consistent with the model, the P1 and …

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Опубликована Апрель 1, 2016

In the current study, two standardized English-language assessments, the AWMA by T.P. Alloway (2007) and the WMRS (Alloway, Gathercole, & Kirkwood, 2008), were translated into Russian. The translated version of the AWMA was undertaken by 51 adults and 73 primary school children, and the translated version of the WMRS was completed by the teachers who worked with those children. The WMRS is a questionnaire list for teachers with 20 items which describe possible behavior manifestations of poor working memory in the classroom. The AWMA is a computer test battery with 12 subtests which aim to assess verbal short-term memory, verbal …

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Опубликована Сен. 18, 2014

The influence of expectation on inattentional blindness (IB) was investigated using a lexical-based IB task. In two experiments, 235 participants performed word compilations from briefly presented letters and combinations of letters with an unexpected syllable appearing in one of the trials. In Experiment 1, we varied the frequency and grammatical form ofthe presented words, evaluating the role of “general” and “contextual” expectations. The results showed the effect of frequency but not of the grammatical form of the words. Experiment 2 controlled for the role of the state of completion of the word compilation in generating “contextual” expectations. We varied two …

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