Anti-Hypertensive Herbs and Their Mechanisms of Action: Part II

Frontiers in Pharmacology, Год журнала: 2016, Номер 7

Опубликована: Март 8, 2016

Traditional medicine has a history extending back to thousands of years, and during the intervening time, man identified healing properties very broad range plants. Globally, use herbal therapies treat manage cardiovascular disease (CVD) is on rise. This second part our comprehensive review where we discuss mechanisms plants herbs used for treatment management high blood pressure. Similar first part, PubMed ScienceDirect databases were utilized, following keywords phrases as inclusion criteria: hypertension, pressure, medicine, complementary alternative endothelial cells, nitric oxide, vascular smooth muscle cell (VSMC) proliferation, hydrogen sulfide, nuclear factor kappa-B, oxidative stress epigenetics/epigenomics. Each aforementioned was co-joined with plant or herb in question, possible its constituent molecule(s). deals particular that are used, albeit less frequently, hypertension. We then interplay between herbs/prescription drugs herbs/epigenetics context this disease. The concludes recommendation more rigorous, well-developed clinical trials concretely determine beneficial impact hypertension disease-free living.

Язык: Английский

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Recent progress in polysaccharides fromPanax ginsengC. A. Meyer

Food & Function, Год журнала: 2020, Номер 12(2), С. 494 - 518

Опубликована: Дек. 17, 2020

Panax ginseng C. A. Meyer (P. ginseng) has a long history of medicinal use and can treat variety diseases. P. contains active ingredients, such as saponins, polypeptides, volatile oils, polysaccharides. Among them, saponins have always been considered the main components responsible for its pharmacological activities. However, more studies shown that polysaccharides play an indispensable role in value ginseng. Modern biological medical found complex structural characteristics diverse activities, immune regulation, anti-tumor, antioxidant, hypoglycemic, anti-radiation functions, among others. Additionally, are closely related to their activity. In this review, research background, extraction, purification, characteristics, activities from different parts (roots, flowers stems leaves, berries) under growth conditions (artificially cultivated ginseng, mountain wild summarized. The purified were reviewed. Meanwhile, introduced, some possible mechanisms listed. Furthermore, structure-activity relationship was discussed. Some perspectives study also provided.

Язык: Английский

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Ginsenoside Rc from Panax ginseng exerts anti-inflammatory activity by targeting TANK-binding kinase 1/interferon regulatory factor-3 and p38/ATF-2

Journal of Ginseng Research, Год журнала: 2016, Номер 41(2), С. 127 - 133

Опубликована: Фев. 10, 2016

Ginsenoside Rc (G-Rc) is one of the major protopanaxadiol-type saponins isolated from Panax ginseng, a well-known medicinal herb with many beneficial properties including anticancer, anti-inflammatory, antiobesity, and antidiabetic effects. In this study, we investigated effects G-Rc on inflammatory responses in vitro examined mechanisms these effects.The inflammation system used lipopolysaccharide-treated macrophages, tumor necrosis factor-α/interferon-γ-treated synovial cells, HEK293 cells transfected various inducers inflammation.G-Rc significantly inhibited expression macrophage-derived cytokines, such as factor-α interleukin-1β. also markedly suppressed activation TANK-binding kinase 1/IκB ε/interferon regulatory factor-3 p38/ATF-2 signaling activated RAW264.7 human cells.G-Rc exerts its anti-inflammatory actions by suppressing signaling.

Язык: Английский

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Selected commercial plants: A review of extraction and isolation of bioactive compounds and their pharmacological market value

Trends in Food Science & Technology, Год журнала: 2018, Номер 82, С. 89 - 109

Опубликована: Окт. 9, 2018

Язык: Английский

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Chinese Herbal Medicine on Cardiovascular Diseases and the Mechanisms of Action

Frontiers in Pharmacology, Год журнала: 2016, Номер 7

Опубликована: Ноя. 30, 2016

Cardiovascular diseases are the principal cause of death worldwide. The potentially serious adverse effects therapeutic drugs lead to growing awareness role Chinese herbal medicine in treatment cardiovascular diseases. has been widely used many countries especially China from antiquity, however, mechanisms by which acts prevention and far clear. In this review, we briefly describe characteristics comparing with western medicine. Then summarize formulae herbs/natural products applied clinic animal studies being sorted according specific Most importantly, elaborate existing investigations into compounds act at cellular levels, including vascular smooth muscle cells, endothelial cardiomyocytes immune cells. Future research should focus on well-designed trial, in-depth mechanic study, side herbs drug interactions. Studies developing new agents effectiveness safety traditional is promising for patients

Язык: Английский

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Microbial Metabolites Determine Host Health and the Status of Some Diseases

International Journal of Molecular Sciences, Год журнала: 2019, Номер 20(21), С. 5296 - 5296

Опубликована: Окт. 24, 2019

The gastrointestinal (GI) tract is a highly complex organ composed of the intestinal epithelium layer, microbiota, and local immune system. Intestinal microbiota residing in GI engages mutualistic relationship with host. Different sections contain distinct proportions resulting presence unique bacterial products each section. converts ingested nutrients into metabolites that target either population or host cells. Metabolites act as messengers information between composition thus impact development, health, pathogenesis. Many recent studies have focused on modulation gut their to improve health prevent treat diseases. In this review, we focus production microbial metabolites, biological cells, effect contribute improvements inflammatory bowel diseases metabolic Understanding role protection against disease might offer an intriguing approach regulate disease.

Язык: Английский

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Adaptogenic herb ginseng (Panax) as medical food: Status quo and future prospects

Biomedicine & Pharmacotherapy, Год журнала: 2016, Номер 85, С. 120 - 127

Опубликована: Дек. 5, 2016

Язык: Английский

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Characteristics of Panax ginseng Cultivars in Korea and China

Molecules, Год журнала: 2020, Номер 25(11), С. 2635 - 2635

Опубликована: Июнь 5, 2020

Ginseng (Panax ginseng Meyer) is one of the most important medicinal herbs in Asia. Its pharmacological activity comes from ginsenosides, and its roots are produced commercially for traditional Oriental medicine. Though 17 Panax species available around world, there was a need to develop cultivars adapted different climatic conditions resistant various diseases while still producing high-quality, high-yield roots. Thus, 12 9 commercial P. have been registered South Korea China, respectively. Those varieties show superiority local landraces. For example, Chunpoong more highly rusty rot disease than Jakyungjong landrace has good root shape; it cultivated produce red ginseng. The Chinese cultivar Jilin Huangguo Renshen higher ginsenoside content This review provides information about offers directions future research, such as intra- interspecific hybridization.

Язык: Английский

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Ginsenosides: A Potential Neuroprotective Agent

BioMed Research International, Год журнала: 2018, Номер 2018, С. 1 - 11

Опубликована: Янв. 1, 2018

Ginseng is a traditional Chinese medicine with wide range of pharmacological activities. Ginsenosides are the major constituents ginseng. have unique biological activity and medicinal value, such as antitumor, anti-inflammatory, antioxidation, inhibition cell apoptosis. With increase stress in life, incidence nervous system diseases also increasing. Neurological pose huge burden on people’s life health. In recent years, some studies shown that ginsenosides certain role prevention treatment neurological diseases. However, research still its infancy, relevant mechanisms complex. paper, we review effects epilepsy, depression, cerebral ischemia reperfusion injury, Alzheimer’s disease, Parkinson’s disease. We hope to provide theoretical basis for by ginsenosides.

Язык: Английский

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American Ginseng (Panax quinquefolium L.) as a Source of Bioactive Phytochemicals with Pro-Health Properties

Nutrients, Год журнала: 2019, Номер 11(5), С. 1041 - 1041

Опубликована: Май 9, 2019

Panax quinquefolium L. (American Ginseng, AG) is an herb characteristic for regions of North America and Asia. Due to its beneficial properties it has been extensively investigated decades. Nowadays, one the most commonly applied medical herbs worldwide. Active compounds AG are ginsenosides, saponins glycosides group that abundant in roots, leaves, stem, fruits plant. Ginsenosides suggested be primarily responsible health-beneficial effects AG. acts on nervous system; was reported improve cognitive function a mouse model Alzheimer's disease, display anxiolytic activity, neuroprotective against neuronal damage resulting from ischemic stroke animals, demonstrate induce animals. Administration leads inhibition hypertrophy heart failure by regulation reactive oxygen species (ROS) mice as well depletion cardiac contractile rats. It also anti-diabetic anti-obesity potential increases insulin sensitivity inhibits formation adipose tissue. displays anti-cancer effect induction apoptosis cancer cells reducing local inflammation. exerts antimicrobial several pathogenic strains bacteria. Therefore, presents high health humans should further explored formulate precise nutritional recommendations, assess value prevention therapy some disorders, including cancer.

Язык: Английский

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