Treatment of Insomnia With Traditional Chinese Medicine Presents a Promising Prospect

Phytotherapy Research, Год журнала: 2025, Номер unknown

Опубликована: Апрель 18, 2025

ABSTRACT Insomnia, a prevalent sleep disorder, significantly impacts global health. While Western medications provide temporary relief, their risks of dependency and cognitive impairment have spurred the search for safer alternatives. Traditional Chinese Medicine (TCM) offers promising approach to treating insomnia by focusing on harmonizing balance Yin Yang functions internal organs. This review explores recent research advances in TCM treatment, integrating classical theories with modern scientific understanding key pathological mechanisms, including neurotransmitter regulation (GABA, monoamines), immune‐inflammatory responses, HPA axis, interactions gut microbiota. Growing clinical evidence supports effectiveness prescriptions treatments like acupuncture improving quality, particularly when combined enhance efficacy reduce dependency. However, also has its limitations. Future directions should focus modernizing applications, addressing comorbidities associated insomnia, exploring role microbiota, optimizing medicinal edible homologous products. By traditional knowledge cutting‐edge technologies, holds great potential advancing personalized effective globally.

Язык: Английский

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Neuroprotective effects of electroacupuncture in ischemic stroke: from mechanisms to clinical implications

Frontiers in Aging Neuroscience, Год журнала: 2025, Номер 17

Опубликована: Апрель 24, 2025

Ischemic stroke is a condition caused by an interruption of blood flow to the brain that can lead neurological damage. The severe damage ischemic cognitive impairment and even disability. Reperfusion therapy mainstay treatment for stroke. However, while restoring oxygen tissue reduce or prevent neuronal cell death cerebral ischemia, ischemia/reperfusion may trigger pathological reactions leading Excessive autophagy in cells, disruption cellular oxidative homeostasis stress, apoptosis, glutamatergic excitatory damage, ferroptosis, neuroinflammation are all key pathways contributing injury. Electroacupuncture, as extension traditional Chinese acupuncture, has obvious effects on alleviating Many experiments have observed after electroacupuncture pretreatment rats, was reduced, morphology improved, such autophagy, neuroinflammation, apoptosis were significantly inhibited, recovery blood-brain barrier angiogenesis promoted. Although specific mechanism not known, it great potential Electroacupuncture improve injury new target therapeutic approaches. In future, expected become effective conducting more clinical trials enriching understanding its improving

Язык: Английский

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Electroacupuncture versus sham for insomnia in patients undergoing maintenance hemodialysis: study protocol for a pilot randomized controlled trial

Annals of Medicine, Год журнала: 2025, Номер 57(1)

Опубликована: Апрель 29, 2025

Insomnia causes severe health problems and poor quality of life in patients with end-stage renal disease (ESRD) undergoing maintenance hemodialysis (MHD). Conventional therapies are limited due to the availability opaque evidence, electroacupuncture (EA) is considered an alternative for improving insomnia ESRD MHD. This a study protocol pilot randomized, sham-controlled, single-center, clinical trial. A total 60 MHD will be randomly assigned treatment group (EA, 3 sessions per week 4 weeks), or sham (sham EA, weeks) 1:1 ratio. Participants complete trial by visiting research center at Week 8 follow-up assessment. The primary outcome response rate: proportion achieving minimal clinically important difference, which defined as ≥7 points on severity index (ISI) compared baseline. Secondary outcomes include sleep diary, ISI, pittsburgh (PSQI), short form survey-12 (SF-12), fatigue scale (FSS), 24-Hour ambulatory blood pressure, plasma levels C-reactive protein (CRP) D-Dimer. first standardized investigating efficacy safety EA may provide evidence application Chinese Clinical Trial Registry (registered number: ChiCTR2300071814).

Язык: Английский

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Efficacy and mechanism of long-snake moxibustion for treating insomnia in breast cancer survivors: study protocol for a randomized controlled trial

Frontiers in Neurology, Год журнала: 2025, Номер 16

Опубликована: Апрель 30, 2025

Insomnia (difficulty falling or staying asleep) is a common issue among breast cancer survivors, significantly impacting their quality of life. Current treatments, primarily pharmacological and psychological, have limitations: the former often causes side effects, while latter faces accessibility barriers. Long-snake moxibustion (LSM), traditional Chinese medicine (TCM) technique, involves applying along governor vessel, which an important meridian in TCM that plays key role regulating brain function. LSM characterized by its minimal ease application, cost-effectiveness, with preliminary studies supporting potential for treating insomnia. This study aims to further investigate therapeutic effectiveness alleviating insomnia survivors explore underlying mechanisms. single-center, rater-masked, randomized controlled trial will enroll 100 chronic insomnia, who be randomly assigned 1:1 ratio either group waitlist control group. During 4-week treatment period, all participants receive standard care, additionally receiving twice week. The primary efficacy outcome change Severity Index (ISI) score at end intervention. Secondary outcomes include changes hypnotic medication use, Pittsburgh Sleep Quality (PSQI) scores, Piper Fatigue Scale (PFS) Functional Assessment Cancer Therapy-Breast (FACT-B) scores. Mechanistic evaluations assess serum biochemical markers, gut microbiota composition, metabolomic profiles. If proven effective, this provide critical clinical evidence as viable accessible survivors. findings could influence practice offering non-pharmacological option, improving patient outcomes, reducing dependence on interventions. Furthermore, exploring mechanisms may enhance our understanding how works, paving way future research. http://itmctr.ccebtcm.org.cn/, identifier ITMCTR2024000578.

Язык: Английский

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An analysis of electroacupuncture as adjunctive treatment for insomnia: a new perspective targeting GABA-mediated microbiome-gut-brain axis

Frontiers in Neurology, Год журнала: 2025, Номер 16

Опубликована: Апрель 30, 2025

Insomnia is a prevalent psychiatric disorder that significantly impacts mental and physical health. Emerging evidence suggests gut microbiota, particularly γ-aminobutyric acid (GABA) producing bacteria, plays critical role in the microbiome-gut-brain axis (MGBA), influencing sleep states. Electroacupuncture (EA) has been shown to have favorable anti-insomnia effects. This research protocol outlines randomized controlled trial (RCT) designed investigate efficacy of EA modulating GABA levels via MGBA alleviate insomnia. The study will use glutamate (Glu) concentrations p-chlorophenylalanine (PCPA) -induced insomnia rat model examine whether at specific acupoints can increase brain plasma by enhancing abundance GABA-producing bacteria. A second experiment transplant stool from rats into germ-free mice evaluate causal microbiota pathology. Primary outcome measures include changes Glu levels, data about open field test, composition. provide insights therapeutic mechanisms targeting treatment contribute development novel strategies. approved Laboratory Animal Center Xiamen University (No. XMULAC20220100). findings be submitted for publication peer-reviewed academic journals.

Язык: Английский

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