Frontiers in Neurology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 30, 2025
Insomnia
is
a
prevalent
psychiatric
disorder
that
significantly
impacts
mental
and
physical
health.
Emerging
evidence
suggests
gut
microbiota,
particularly
γ-aminobutyric
acid
(GABA)
producing
bacteria,
plays
critical
role
in
the
microbiome-gut-brain
axis
(MGBA),
influencing
sleep
states.
Electroacupuncture
(EA)
has
been
shown
to
have
favorable
anti-insomnia
effects.
This
research
protocol
outlines
randomized
controlled
trial
(RCT)
designed
investigate
efficacy
of
EA
modulating
GABA
levels
via
MGBA
alleviate
insomnia.
The
study
will
use
glutamate
(Glu)
concentrations
p-chlorophenylalanine
(PCPA)
-induced
insomnia
rat
model
examine
whether
at
specific
acupoints
can
increase
brain
plasma
by
enhancing
abundance
GABA-producing
bacteria.
A
second
experiment
transplant
stool
from
rats
into
germ-free
mice
evaluate
causal
microbiota
pathology.
Primary
outcome
measures
include
changes
Glu
levels,
data
about
open
field
test,
composition.
provide
insights
therapeutic
mechanisms
targeting
treatment
contribute
development
novel
strategies.
approved
Laboratory
Animal
Center
Xiamen
University
(No.
XMULAC20220100).
findings
be
submitted
for
publication
peer-reviewed
academic
journals.
Phytotherapy Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 18, 2025
ABSTRACT
Insomnia,
a
prevalent
sleep
disorder,
significantly
impacts
global
health.
While
Western
medications
provide
temporary
relief,
their
risks
of
dependency
and
cognitive
impairment
have
spurred
the
search
for
safer
alternatives.
Traditional
Chinese
Medicine
(TCM)
offers
promising
approach
to
treating
insomnia
by
focusing
on
harmonizing
balance
Yin
Yang
functions
internal
organs.
This
review
explores
recent
research
advances
in
TCM
treatment,
integrating
classical
theories
with
modern
scientific
understanding
key
pathological
mechanisms,
including
neurotransmitter
regulation
(GABA,
monoamines),
immune‐inflammatory
responses,
HPA
axis,
interactions
gut
microbiota.
Growing
clinical
evidence
supports
effectiveness
prescriptions
treatments
like
acupuncture
improving
quality,
particularly
when
combined
enhance
efficacy
reduce
dependency.
However,
also
has
its
limitations.
Future
directions
should
focus
modernizing
applications,
addressing
comorbidities
associated
insomnia,
exploring
role
microbiota,
optimizing
medicinal
edible
homologous
products.
By
traditional
knowledge
cutting‐edge
technologies,
holds
great
potential
advancing
personalized
effective
globally.
Frontiers in Aging Neuroscience,
Год журнала:
2025,
Номер
17
Опубликована: Апрель 24, 2025
Ischemic
stroke
is
a
condition
caused
by
an
interruption
of
blood
flow
to
the
brain
that
can
lead
neurological
damage.
The
severe
damage
ischemic
cognitive
impairment
and
even
disability.
Reperfusion
therapy
mainstay
treatment
for
stroke.
However,
while
restoring
oxygen
tissue
reduce
or
prevent
neuronal
cell
death
cerebral
ischemia,
ischemia/reperfusion
may
trigger
pathological
reactions
leading
Excessive
autophagy
in
cells,
disruption
cellular
oxidative
homeostasis
stress,
apoptosis,
glutamatergic
excitatory
damage,
ferroptosis,
neuroinflammation
are
all
key
pathways
contributing
injury.
Electroacupuncture,
as
extension
traditional
Chinese
acupuncture,
has
obvious
effects
on
alleviating
Many
experiments
have
observed
after
electroacupuncture
pretreatment
rats,
was
reduced,
morphology
improved,
such
autophagy,
neuroinflammation,
apoptosis
were
significantly
inhibited,
recovery
blood-brain
barrier
angiogenesis
promoted.
Although
specific
mechanism
not
known,
it
great
potential
Electroacupuncture
improve
injury
new
target
therapeutic
approaches.
In
future,
expected
become
effective
conducting
more
clinical
trials
enriching
understanding
its
improving
Annals of Medicine,
Год журнала:
2025,
Номер
57(1)
Опубликована: Апрель 29, 2025
Insomnia
causes
severe
health
problems
and
poor
quality
of
life
in
patients
with
end-stage
renal
disease
(ESRD)
undergoing
maintenance
hemodialysis
(MHD).
Conventional
therapies
are
limited
due
to
the
availability
opaque
evidence,
electroacupuncture
(EA)
is
considered
an
alternative
for
improving
insomnia
ESRD
MHD.
This
a
study
protocol
pilot
randomized,
sham-controlled,
single-center,
clinical
trial.
A
total
60
MHD
will
be
randomly
assigned
treatment
group
(EA,
3
sessions
per
week
4
weeks),
or
sham
(sham
EA,
weeks)
1:1
ratio.
Participants
complete
trial
by
visiting
research
center
at
Week
8
follow-up
assessment.
The
primary
outcome
response
rate:
proportion
achieving
minimal
clinically
important
difference,
which
defined
as
≥7
points
on
severity
index
(ISI)
compared
baseline.
Secondary
outcomes
include
sleep
diary,
ISI,
pittsburgh
(PSQI),
short
form
survey-12
(SF-12),
fatigue
scale
(FSS),
24-Hour
ambulatory
blood
pressure,
plasma
levels
C-reactive
protein
(CRP)
D-Dimer.
first
standardized
investigating
efficacy
safety
EA
may
provide
evidence
application
Chinese
Clinical
Trial
Registry
(registered
number:
ChiCTR2300071814).
Frontiers in Neurology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 30, 2025
Insomnia
(difficulty
falling
or
staying
asleep)
is
a
common
issue
among
breast
cancer
survivors,
significantly
impacting
their
quality
of
life.
Current
treatments,
primarily
pharmacological
and
psychological,
have
limitations:
the
former
often
causes
side
effects,
while
latter
faces
accessibility
barriers.
Long-snake
moxibustion
(LSM),
traditional
Chinese
medicine
(TCM)
technique,
involves
applying
along
governor
vessel,
which
an
important
meridian
in
TCM
that
plays
key
role
regulating
brain
function.
LSM
characterized
by
its
minimal
ease
application,
cost-effectiveness,
with
preliminary
studies
supporting
potential
for
treating
insomnia.
This
study
aims
to
further
investigate
therapeutic
effectiveness
alleviating
insomnia
survivors
explore
underlying
mechanisms.
single-center,
rater-masked,
randomized
controlled
trial
will
enroll
100
chronic
insomnia,
who
be
randomly
assigned
1:1
ratio
either
group
waitlist
control
group.
During
4-week
treatment
period,
all
participants
receive
standard
care,
additionally
receiving
twice
week.
The
primary
efficacy
outcome
change
Severity
Index
(ISI)
score
at
end
intervention.
Secondary
outcomes
include
changes
hypnotic
medication
use,
Pittsburgh
Sleep
Quality
(PSQI)
scores,
Piper
Fatigue
Scale
(PFS)
Functional
Assessment
Cancer
Therapy-Breast
(FACT-B)
scores.
Mechanistic
evaluations
assess
serum
biochemical
markers,
gut
microbiota
composition,
metabolomic
profiles.
If
proven
effective,
this
provide
critical
clinical
evidence
as
viable
accessible
survivors.
findings
could
influence
practice
offering
non-pharmacological
option,
improving
patient
outcomes,
reducing
dependence
on
interventions.
Furthermore,
exploring
mechanisms
may
enhance
our
understanding
how
works,
paving
way
future
research.
http://itmctr.ccebtcm.org.cn/,
identifier
ITMCTR2024000578.
Frontiers in Neurology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 30, 2025
Insomnia
is
a
prevalent
psychiatric
disorder
that
significantly
impacts
mental
and
physical
health.
Emerging
evidence
suggests
gut
microbiota,
particularly
γ-aminobutyric
acid
(GABA)
producing
bacteria,
plays
critical
role
in
the
microbiome-gut-brain
axis
(MGBA),
influencing
sleep
states.
Electroacupuncture
(EA)
has
been
shown
to
have
favorable
anti-insomnia
effects.
This
research
protocol
outlines
randomized
controlled
trial
(RCT)
designed
investigate
efficacy
of
EA
modulating
GABA
levels
via
MGBA
alleviate
insomnia.
The
study
will
use
glutamate
(Glu)
concentrations
p-chlorophenylalanine
(PCPA)
-induced
insomnia
rat
model
examine
whether
at
specific
acupoints
can
increase
brain
plasma
by
enhancing
abundance
GABA-producing
bacteria.
A
second
experiment
transplant
stool
from
rats
into
germ-free
mice
evaluate
causal
microbiota
pathology.
Primary
outcome
measures
include
changes
Glu
levels,
data
about
open
field
test,
composition.
provide
insights
therapeutic
mechanisms
targeting
treatment
contribute
development
novel
strategies.
approved
Laboratory
Animal
Center
Xiamen
University
(No.
XMULAC20220100).
findings
be
submitted
for
publication
peer-reviewed
academic
journals.