Acta Psychologica, Год журнала: 2025, Номер 253, С. 104728 - 104728
Опубликована: Янв. 30, 2025
Язык: Английский
eNeuro, Год журнала: 2024, Номер 11(8), С. ENEURO.0454 - 23.2024
Опубликована: Июль 31, 2024
Comorbid chronic neuropathic pain and anxiety is a common disease that represents major clinical challenge. The underlying mechanisms of are not entirely understood, which limits the exploration effective treatment methods. Glutamatergic neurons in ventrolateral periaqueductal gray (vlPAG) have been implicated regulating pain, but potential roles vlPAG pain-induced investigated. Herein, whole-cell recording immunofluorescence showed excitability CamkIIα (vlPAG CamkIIα+ neurons) was decreased mice with spared nerve injury (SNI), while electroacupuncture (EA) activated these neurons. We also chemogenetic inhibition resulted allodynia anxiety-like behaviors naive mice. Furthermore, activation reduced SNI, EA had similar effect alleviating symptoms. Nevertheless, combined failed to further relieve behaviors. Artificial abolished analgesic anxiolytic effects EA. Overall, our study reveals novel mechanism shows may comorbid by activating
Язык: Английский
Процитировано
3
Complementary Therapies in Medicine, Год журнала: 2024, Номер 85, С. 103074 - 103074
Опубликована: Авг. 10, 2024
The number of systematic reviews and meta-analyses (SRs/MAs) on acupuncture therapy for CRI is increasing; however, the credibility evidence remains unclear with controversial results, necessitating a comprehensive evaluation. We aimed to critically assess in SRs/MAs regarding effectiveness from various aspects conduct an exploratory analysis identify potential issues. Two reviewers conducted searches eight databases. randomized controlled trials are included. After screening according inclusion exclusion criteria, two extracted data eligible detailed assessment methodological quality, risk bias, quality using AMSTAR-2, ROBIS, GRADE tools. Meanwhile, we calculated Corrected Covered Area (CCA) leveraging GROOVE tool. manually excluding duplicate studies, bias primary studies meta-analysis. included 10 SRs/MAs. AMSRAT-2 results indicate significant flaws SRs/MAs, main issues focusing lack provision checklist studies. Furthermore, over half have high due incomplete retrieval failure follow protocol. Most demonstrated considerable completeness reporting quality. Notably, overall level low. High overlap indicates redundant Exploratory suggests that may be effective CRI; caution needed interpreting results. Sensitivity stable, funnel plot no publication bias. acknowledge safety acupuncture. Currently, treating low improvements methodology, reporting. Acupuncture shows but lacks sufficient support; high-level warranted elucidate CRI.
Язык: Английский
Процитировано
3
Brain Research Bulletin, Год журнала: 2024, Номер 217, С. 111071 - 111071
Опубликована: Сен. 5, 2024
Cerebral ischemia-reperfusion (CIR) injury is a devastating consequence of stroke characterized by oxidative stress-induced neuronal damage. Electroacupuncture (EA) has emerged as potential therapeutic intervention for ischemic stroke, but its underlying mechanisms remain incompletely understood. This study aimed to elucidate whether EA exerts anti-oxidative stress effects against CIR modulating the GSK-3β/Nrf2 pathway.
Язык: Английский
Процитировано
3
Brain Research Bulletin, Год журнала: 2025, Номер 221, С. 111207 - 111207
Опубликована: Янв. 14, 2025
Depression is commonly associated with gastrointestinal (GI) disorders, such as constipation, which can potentially intensify depressive symptoms. The interplay between these conditions believed to be facilitated by the gut-brain axis, suggests a complex bidirectional interaction. Current treatments, antidepressants and prokinetics, are often side effects high recurrence rates, highlighting need for effective treatments targeting both depression constipation. This study was designed assess therapeutic efficacy of electroacupuncture (EA) in conjunction Tongbian decoction (TB) management while also investigating underlying mechanisms through lens axis. Chronic unpredictable mild stress (CUMS) employed induce comorbidity model constipation mice, followed administration EA, EA + TB, fluoxetine (FLX). findings demonstrated that antidepressant combination were more pronounced than those alone. TB treatment significantly ameliorated anxiety-like behaviors, restored cognitive function, enhanced motility chronic mice. Furthermore, reduced intestinal inflammation, neuronal morphology, increased expression tryptophan hydroxylase 2 (TPH2) prefrontal cortex (PFC) colon, elevated serum levels 5-hydroxytryptophan (5-HTP)-a molecule acts connector-and promoted synthesis production serotonin (5-HT) tract brain. Contrastingly, FLX showed limited improving In conclusion, regulates TPH2/5-HT pathway via demonstrating synergistic regulation nervous systems, favorable prokinetic effects.
Язык: Английский
Процитировано
0
Acta Psychologica, Год журнала: 2025, Номер 253, С. 104728 - 104728
Опубликована: Янв. 30, 2025
Язык: Английский
Процитировано
0