eNeuro,
Journal Year:
2024,
Volume and Issue:
11(8), P. ENEURO.0454 - 23.2024
Published: July 31, 2024
Comorbid
chronic
neuropathic
pain
and
anxiety
is
a
common
disease
that
represents
major
clinical
challenge.
The
underlying
mechanisms
of
are
not
entirely
understood,
which
limits
the
exploration
effective
treatment
methods.
Glutamatergic
neurons
in
ventrolateral
periaqueductal
gray
(vlPAG)
have
been
implicated
regulating
pain,
but
potential
roles
vlPAG
pain-induced
investigated.
Herein,
whole-cell
recording
immunofluorescence
showed
excitability
CamkIIα
(vlPAG
CamkIIα+
neurons)
was
decreased
mice
with
spared
nerve
injury
(SNI),
while
electroacupuncture
(EA)
activated
these
neurons.
We
also
chemogenetic
inhibition
resulted
allodynia
anxiety-like
behaviors
naive
mice.
Furthermore,
activation
reduced
SNI,
EA
had
similar
effect
alleviating
symptoms.
Nevertheless,
combined
failed
to
further
relieve
behaviors.
Artificial
abolished
analgesic
anxiolytic
effects
EA.
Overall,
our
study
reveals
novel
mechanism
shows
may
comorbid
by
activating
Frontiers in Neuroscience,
Journal Year:
2024,
Volume and Issue:
18
Published: Jan. 29, 2024
Objectives
The
acupoint
LR3
(Taichong)
is
frequently
utilized
in
clinical
acupuncture.
However,
its
underlying
neural
mechanisms
remain
not
fully
elucidated,
with
speculations
suggesting
close
association
specific
brain
activity
patterns.
Methods
A
comprehensive
literature
search
was
undertaken
across
several
online
databases,
such
as
PubMed,
Web
of
Science,
Embase,
Cochrane
Library,
CNKI
(China
National
Knowledge
Infrastructure),
Wanfang
Database,
VIP
and
the
Chinese
Biomedical
Database.
Two
independent
researchers
handled
study
selection,
quality
assessment,
data
extraction
processes.
Using
seed-based
d-mapping
meta-analysis
approach,
we
evaluated
regions
activated
by
acupuncture
healthy
subjects.
Subsequent
subgroup
analysis
stratified
fMRI
types,
regression
analyses
were
performed
considering
duration
acupuncture,
depth
needle
insertion,
diameter.
identified
active
then
intricately
projected
onto
large-scale
functional
networks.
Results
total
10
studies
met
criteria
for
inclusion,
encompassing
319
right-handed
participants.
indicates
that
at
activates
right
postcentral
gyrus,
left
thalamus,
middle
frontal
superior
gyrus.
Additionally,
meta-regression
highlights
increased
correlates
progressively
intensified
activation
Subgroup
posits
variations
type
employed
might
account
heterogeneity
pooled
results.
Concurrently,
network
identifies
primary
aligning
Basal
ganglia
network,
Auditory
Left
executive
control
Posterior
salience
Right
Sensorimotor
Conclusion
Acupuncture
subjects
selectively
linked
to
pain
perception,
emotional
processing,
linguistic
functions.
Extending
retention
intensifies
These
findings
enrich
our
comprehension
neurobiological
underpinnings
acupuncture’s
role
mitigation
regulation.
eNeuro,
Journal Year:
2024,
Volume and Issue:
11(8), P. ENEURO.0454 - 23.2024
Published: July 31, 2024
Comorbid
chronic
neuropathic
pain
and
anxiety
is
a
common
disease
that
represents
major
clinical
challenge.
The
underlying
mechanisms
of
are
not
entirely
understood,
which
limits
the
exploration
effective
treatment
methods.
Glutamatergic
neurons
in
ventrolateral
periaqueductal
gray
(vlPAG)
have
been
implicated
regulating
pain,
but
potential
roles
vlPAG
pain-induced
investigated.
Herein,
whole-cell
recording
immunofluorescence
showed
excitability
CamkIIα
(vlPAG
CamkIIα+
neurons)
was
decreased
mice
with
spared
nerve
injury
(SNI),
while
electroacupuncture
(EA)
activated
these
neurons.
We
also
chemogenetic
inhibition
resulted
allodynia
anxiety-like
behaviors
naive
mice.
Furthermore,
activation
reduced
SNI,
EA
had
similar
effect
alleviating
symptoms.
Nevertheless,
combined
failed
to
further
relieve
behaviors.
Artificial
abolished
analgesic
anxiolytic
effects
EA.
Overall,
our
study
reveals
novel
mechanism
shows
may
comorbid
by
activating
