Journal of Digestive Cancer Research,
Год журнала:
2023,
Номер
11(2), С. 77 - 84
Опубликована: Авг. 20, 2023
Dietary
habits
play
a
significant
role
in
the
development
of
colorectal
cancer.Over
past
decades,
various
epidemiological
and
meta-studies
have
indicated
close
relationship
among
nutrient
intake,
dietary
habits,
incidence
cancer.Less
consumption
red
or
processed
meat
alcohol,
if
possible,
high
vitamins
B
D,
garlic,
magnesium,
fiber,
calcium,
omega-3
fatty
acids
reduce
risk
cancer.Additionally,
balanced
diet
intake
proper
weight
maintenance
are
crucial
for
colon
cancer
prevention.All
these
factors
modifiable
associated
with
recurrence
overall
survival
after
development,
thereby
greatly
contributing
to
nutritional
treatment
patients
diagnosed
cancer.
Liver International,
Год журнала:
2023,
Номер
44(1), С. 6 - 14
Опубликована: Окт. 13, 2023
Abstract
Background
&
Aims
Obesity
and
non‐alcoholic
fatty
liver
disease
(NAFLD)
are
known
risk
factors
for
gastrointestinal
(GI)
cancers.
However,
GI
carcinogenesis
in
lean
NAFLD
patients
remains
unclear.
This
systematic
review
meta‐analysis
aims
to
investigate
the
association
between
cancer
risk.
Methods
PubMed,
Embase
Cochrane
Library
databases
were
systematically
searched
(from
inception
date
April
2023)
cohort
studies
assessing
cancers
(body
mass
index
[BMI]
<
25
kg/m
2
or
23
Asians)
non‐lean
(BMI
≥25
≥
individuals.
Data
from
eligible
extracted,
was
carried
out
using
a
random
effects
model
obtain
ratios
(RRs)
with
95%
confidence
intervals
(CIs).
Subgroup
analyses,
meta‐regressions
sensitivity
analyses
also
performed.
study
registered
PROSPERO
(CRD42023420902).
Results
Eight
56,745
individuals
(11%
lean)
704
cases
of
incident
included.
Lean
associated
higher
hepatic
(RR
1.77,
CI
1.15–2.73),
pancreatic
1.97,
1.01–3.86)
colorectal
1.53,
1.12–2.09),
compared
NAFLD.
No
significant
differences
observed
oesophagus,
gastric,
biliary
small
intestine
Conclusions
shows
that
have
an
increased
liver,
patients,
emphasizing
need
explore
tailored
prevention
strategies
this
specific
patient
group.
Further
research
is
required
mechanisms
underlying
Abstract
The
incidence
of
colorectal
cancer
(CRC)
has
been
steadily
rising,
and
obesity
identified
as
a
significant
risk
factor.
Numerous
studies
suggest
strong
correlation
between
excess
body
weight
increased
CRC,
but
comprehensive
quantification
through
pooled
analysis
remains
limited.
This
study
aims
to
systematically
review
meta-analyze
the
existing
literature
evaluate
association
CRC
risk,
considering
variations
across
sex
designs.
A
systematic
search
was
conducted
in
PubMed,
Cochrane
Central
Register
Controlled
Trials
(CENTRAL),
Web
Science
identify
randomized
controlled
trials
human
clinical
from
1992
2024.
Statistical
performed
using
https://metaanalysisonline.com
web
application
random
effects
model
estimate
hazard
rates
(HR).
Forest
plots,
funnel
Z-score
plots
were
utilized
visualize
results.
We
52
14
case–control
studies,
encompassing
total
83,251,050
236,877
subjects,
respectively.
indicated
that
significantly
prevalence
(HR
=
1.36,
95%
CI
1.24–1.48,
p
<
0.01).
effect
consistent
sexes,
with
HRs
1.57
(95%
1.38–1.78,
0.01)
for
males
1.25
1.14–1.38,
females.
Case–control
specifically
showed
an
effect,
marginal
significance
only
1.27,
0.98–1.65,
0.07).
plot
need
additional
group.
heterogeneity
observed
all
four
settings.
meta-analysis
provides
robust
evidence
is
factor
cancer,
overall
rate
indicating
36%
risk.
pronounced
both
showing
slightly
higher
compared
Although
weaker
association,
trend
supports
link
CRC.
These
results
underscore
importance
public
health
interventions
aimed
at
reducing
potentially
lower
cancer.
Cancers,
Год журнала:
2024,
Номер
16(18), С. 3224 - 3224
Опубликована: Сен. 22, 2024
Glucagon-like
peptide-1
receptor
agonists
(GLP-1
RAs)
are
becoming
more
popular
in
managing
type
2
diabetes
mellitus
(T2DM).
Concerns
linger
over
potential
links
to
malignancies
like
pancreatic
and
thyroid
cancers,
requiring
research
clarify
their
safety
profiles.
Additionally,
evidence
suggests
GLP-1
RAs
may
lower
colorectal
cancer
risk,
especially
obese
overweight
individuals,
indicating
a
protective
effect
beyond
weight
loss.
Current
studies
leave
gap
comprehensively
understanding
risks
associated
with
RAs,
which
prompts
further
enhance
our
of
overall
safety.
Diseases of the Esophagus,
Год журнала:
2025,
Номер
38(2)
Опубликована: Март 3, 2025
Summary
The
association
between
body
mass
index
(BMI)
and
cancers
of
the
esophagus
stomach
remains
complex
requires
further
exploration.
This
study
aimed
to
investigate
this
association,
including
early-onset
(<
50
years)
cancer
related
mortality.
A
nationwide
registry-based
cohort
was
performed
by
linking
data
from
multiple
national
registries
in
Norway.
included
1,723,692
individuals,
with
22,473
gastroesophageal
cases
identified
over
55,701,169
person-years
follow-up.
In
men,
a
5
kg/m2
increase
BMI
associated
an
increased
risk
esophageal
(HR
1.34,
95%CI
1.22–1.48)
cardia
adenocarcinoma
1.36,
95%
CI,
1.22–1.50).
finding
extended
individuals
high
early
life
(16–29
for
adenocarcinoma.
highest
per
observed
2.49,
1.23–5.02)
2.26,
1.19–4.27).
Among
women,
higher
both
1.28,
1.13–1.44)
gastric
1.04,
1.01–1.07).
Women
elevated
also
demonstrated
these
cancers.
sexes,
inversely
squamous
cell
carcinoma
esophagus.
No
cancer-related
highlights
adenocarcinomas
increasing
BMI,
notable
sex,
age,
site-specific
variations.
findings
point
heightened
men
BMI.
Chinese Journal of Cancer Research,
Год журнала:
2023,
Номер
35(6), С. 606 - 617
Опубликована: Янв. 1, 2023
China
ranks
the
first
worldwide
in
number
of
new
colorectal
cancer
(CRC)
cases
and
CRC-related
deaths.
The
increasing
incidence
early-onset
CRC
recent
years
highlights
challenges
related
to
screening
prevention.
High-quality
colonoscopy
is
universally
used
gold
standard
for
screening.
Risk
assessment
combined
with
a
two-step
strategy
based
on
non-invasive
examinations
was
proven
be
highly
effective.
However,
systematic
use
well-established
risk
factors
associated
CRC,
beyond
age,
could
better
identify
those
who
might
harbor
advanced
neoplasia,
improve
diagnostic
yield
current
modalities,
optimize
selection
individuals
benefit
most
from
preventive
strategies.
"Personalization"
"Standardization"
are
future
development
directions
screening,
initiation
at
high
follow-up
after
treatment,
which
key
ensure
efficiency.
Journal of Anatomy and Histopathology,
Год журнала:
2024,
Номер
13(1), С. 57 - 65
Опубликована: Апрель 7, 2024
This
paper
presents
a
literature
review
evaluating
the
possibilities
of
using
anthropometry
and
anthropometric
indices
at
present
stage
development
science
medicine,
taking
into
account
personalized
approach
to
predicting
life
health
indicators
various
population
groups.
To
prepare
this
review,
an
analysis
PubMed
database
within
2022–2023
was
carried
out
keywords
“anthropometry”,
“body
mass
index”.
44
643
sources
cited,
were
included
in
final
version.
The
use
body
index
appears
be
cost-effective,
relevant
simple
method
for
application
scientific
research,
preventive
clinical
medicine
solving
wide
range
problems.
ABSTRACT
Background
The
body
rounds
index
(BRI),
an
innovative
obesity
indicator
integrating
waist
circumference
(WC)
and
height,
offers
a
two‐dimensional
assessment
of
obesity.
relationship
between
BRI
trajectories
cancer
has
been
overlooked
in
previous
studies.
This
study
aims
to
explore
the
association
incidence
cancer.
Methods
included
42,022
participants
with
median
age
48.91
years.
Based
on
changes
participants'
during
period
from
2006
2010,
three
trajectory
patterns
were
identified:
low‐stable,
medium‐stable,
high‐stable.
primary
outcome
was
secondary
cancer‐specific
deaths.
death
explored
by
cox
regression
analysis
total,
sex‐specific
age‐specific
populations,
respectively.
Additionally,
we
further
investigated
site‐specific
incidence.
Sensitivity
analyses
applied
exclude
interferences
ensure
stability
results.
Results
After
follow‐up
time
11.04
years,
high‐stable
significantly
associated
increased
risk
occurrence
compared
low‐stable
trajectory.
more
pronounced
middle‐aged
men
(men:
HR
=
1.46,
95%
CI
1.21–1.77,
p
<
0.001;
65:
11.38,
1.15–1.66,
0.001).
substantial
increase
uterine
cancers
(HR
4.92,
1.69–14.33,
0.004).
confirmed
Conclusion
Our
identified
significant
incidence,
this
being
most
men.
Moreover,
strongly
development.
findings
underscore
importance
implementing
lifestyle
modifications
monitoring
values
their
provide
effective
health
guidance.
