RSV Vaccine Effectiveness Against Hospitalization Among US Adults 60 Years and Older

JAMA, Год журнала: 2024, Номер 332(13), С. 1105 - 1105

Опубликована: Сен. 4, 2024

This study evaluates the effectiveness of respiratory syncytial virus vaccine against hospitalization for acute illness among US adults aged 60 years and older.

Язык: Английский

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Respiratory syncytial virus (RSV) vaccine effectiveness against RSV-associated hospitalisations and emergency department encounters among adults aged 60 years and older in the USA, October, 2023, to March, 2024: a test-negative design analysis

The Lancet, Год журнала: 2024, Номер 404(10462), С. 1547 - 1559

Опубликована: Окт. 1, 2024

Язык: Английский

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Key Insights into Respiratory Virus Testing: Sensitivity and Clinical Implications

Microorganisms, Год журнала: 2025, Номер 13(1), С. 63 - 63

Опубликована: Янв. 2, 2025

Acute respiratory infections are a significant challenge in primary care and hospital settings. Viruses the most common etiology overlapping symptomatology among major viruses, such as influenza, severe acute syndrome coronavirus 2, syncytial virus, requires use of diagnostic tests that deliver early accurate results. With increasing availability rapid antigen (RATS), it is tempting to prefer them over polymerase chain reaction (PCR) tests. However, compelling arguments support existing recommendations some European countries maintain PCR testing for patient management throughout year. RATs show sensitivities below 30% with lower viral loads, which can have clinical implications. perform well at cycle threshold (Ct) values, sensitivity reaching 97.9% Ct values 20, drops significantly above 25. Factors affecting load include disease stage, vaccination status, variants, all compromise accuracy Multi-target effectively overcome these issues, ensuring reliable diagnosis. Additionally, detection paucisymptomatic cases essential settings facilitate isolation prevent secondary infections. Economic analyses comprehensive tests, triplex-type detecting SARS-CoV-2, influenza RSV, first-line approach, they reduce case numbers healthcare resource utilization. Maintaining year-round therefore crucial effective

Язык: Английский

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Would senior citizens get vaccinated against RSV? Exploratory analysis using a novel survey instrument

Vacunas, Год журнала: 2025, Номер 26(1), С. 100384 - 100384

Опубликована: Янв. 1, 2025

Язык: Английский

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Respiratory syncytial virus vaccination in older adults and patients with chronic disorders: A position paper from the Portuguese Society of Pulmonology, the Portuguese Association of General and Family Medicine, the Portuguese Society of Cardiology, the Portuguese Society of Infectious Diseases and Clinical Microbiology, the Portuguese Society of Endocrinology, Diabetes and Metabolism, and the Portuguese Society of Internal Medicine

Pulmonology, Год журнала: 2025, Номер 31(1)

Опубликована: Янв. 27, 2025

Background Respiratory syncytial virus (RSV) is an important cause of lower respiratory tract infection, hospitalisation and death in adults.

Язык: Английский

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Burden of Respiratory Syncytial Virus–Associated Hospitalizations in US Adults, October 2016 to September 2023

JAMA Network Open, Год журнала: 2024, Номер 7(11), С. e2444756 - e2444756

Опубликована: Ноя. 13, 2024

Importance Respiratory syncytial virus (RSV) infection can cause severe illness in adults. However, there is considerable uncertainty the burden of RSV-associated hospitalizations among adults prior to RSV vaccine introduction. Objective To describe demographic characteristics hospitalized with laboratory-confirmed and estimate annual rates numbers hospitalizations, intensive care unit (ICU) admissions, in-hospital deaths. Design, Setting, Participants This cross-sectional study used data from Hospitalization Surveillance Network (RSV-NET), a population-based surveillance platform that captures 58 counties 12 states, covering approximately 8% US population. The period spanned 7 seasons 2016-2017 through 2022-2023. Included cases RSV-NET were nonpregnant aged 18 years or older residing catchment area positive test result. Exposure Laboratory-confirmed hospitalization, defined as result within 14 days before during hospitalization. Main Outcomes Measures per 100 000 adult population, stratified by age group. After adjusting for sensitivity undertesting acute respiratory illnesses, extrapolated population hospitalizations. Clinical outcome ICU admissions Results From 2016 2017 2022 2023 seasons, 16 575 (median [IQR] age, 70 [58-81] years; 9641 females [58.2%]). Excluding 2020 2021 when COVID-19 pandemic affected circulation, hospitalization ranged 48.9 (95% CI, 33.4-91.5) 76.2 55.2-122.7) 2018. Rates lowest 49 (8.6 [95% 5.7-16.8] 13.1 11.0-16.1] 2022-2023) highest 75 (244.7 207.9-297.3] 2022-2023 411.4 292.1-695.4] 2017-2018). Annual estimates 123 84 000-230 000) 193 140 000-311 admission 24 400 700-44 800) 34 900 25 500-55 600) same seasons. Estimated deaths 4680 3570-6820) 2018 2019 8620 6220-14 090) Adults accounted 45.6% (range, 43.1%-48.8%) all 38.6% 36.7%-41.0%) 58.7% 51.9%-67.1%) Conclusions Relevance In this introduction vaccines, was associated substantial adults, occurring older. Increasing vaccination has potential reduce clinical outcomes.

Язык: Английский

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Estimating the burden of RSV- and influenza-associated hospitalizations, ICU admissions, and deaths across age and socioeconomic groups in New York State, 2005-2019

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Янв. 12, 2025

Abstract Background Multiple prophylactic products are now available to protect against respiratory syncytial virus (RSV) in different age groups. Assessing the pre-intervention burden of RSV infections across various severity levels and risk groups is crucial, as it provides a baseline for evaluating impact these products. Methods We obtained monthly time series data on hospitalizations, intensive care unit (ICU) admissions, deaths by group, ZIP code, cause New York state from 2005 2019. Socioeconomic status (SES) codes was classified using supervised principal component analysis (PCA). estimated incidence ICU attributable influenza hierarchical Bayesian regression models. Additionally, we assessed severity, defined admission mortality risks, well recording fraction (i.e., percent virus-associated hospitalizations recorded being due specific virus), stratified age, SES, over time. Results The annual RSV-associated admissions were highest infants under 1 low SES group (2,240 [95% credible interval (CrI): 2,200-2,290] 330 CrI: 320-350] per 100,000 person-years). among adults ≥85 years old (61 49-74] In contrast RSV, greatest ≥65 years. varied patients’ increased dramatically with both pathogens (RSV: 11.9% 9.6-14.3%], influenza: 14.4% 13.1-15.6%] year group). Incidence epidemic season, observed an increasing all study period. Conclusions contribute significantly deaths, particularly older adults. Although period, remains lower, Our findings reveal disparity hospitalization younger

Язык: Английский

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Laboratory confirmation of respiratory syncytial virus infection is not associated with increased risk of death in adults with acute respiratory illness

Open Forum Infectious Diseases, Год журнала: 2025, Номер 12(2)

Опубликована: Янв. 15, 2025

Abstract Background Limited data have described the testing patterns and outcomes of adults (≥18 years) with acute respiratory illness (ARI) in emergency department setting. Methods This prospective cohort study includes patients ARI from a program sponsored by Centers for Disease Control Prevention entitled Respiratory Virus Laboratory Emergency Department Network Surveillance (RESP-LENS) August 2021 until March 2024 (91 hospitals). Patients ARIs were identified weekly electronic surveillance 1 or more 130 ICD-10 codes that defined ARI. followed 30 days primary hospitalization mortality. Testing RSV nasopharyngeal swabbing reverse transcription polymerase chain reaction was done as part usual care. Risk 30-day mortality positivity tested generalized estimating equation. Results From 210 394 ARI, 345 185 (28.5%) underwent testing, which positive 2.4%. In who RSV+, overall rate 1.9% compared 2.9% RSV−. Mortality RSV+ status increased age ≥65 years to 3.8% (95% CI, 3.1%–4.5%). However, equation, not associated higher (adjusted odds, 0.79; 95% .75–.84) (odds, 0.62; .53–.74) relative those RSV–. Age years, incremental worsening vital signs, male sex, heart failure independently death. Conclusions Among presenting an their care, laboratory-confirmed risk, including hospitalization, intensive care unit requirement,

Язык: Английский

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Prevalence of Respiratory Syncytial Virus Infection in Hospitalized COPD Patients in Spain Between 2018–2022

Diseases, Год журнала: 2025, Номер 13(1), С. 23 - 23

Опубликована: Янв. 20, 2025

Background: Respiratory syncytial virus (RSV) infection is a common cause of hospital admission. The association between chronic obstructive pulmonary disease (COPD) exacerbation and RSV not well studied. Objective: To analyze the hospitalizations patients with COPD in Spain 2018 2022. Methods: data used were obtained from Spanish Hospital Discharge Database. We selected subjects aged ≥40 years diagnosed COPD, admitted to 1 January 31 December population that met selection criteria was subdivided based on presence an ICD-10 code for infection. obtain comparable populations, each subject infection, without selected, same diagnostic position (1 20), as year admission, sex, age. Results: Among years, 1,429,288 identified having whom 5673 also had number increased during study period. proportion among significantly over time, 0.32% 0.65% 2022, p < 0.001. In-hospital mortality (IHM) but differences significant (6.23% vs. 6.79% 2022). Patients had, compared those higher use mechanical ventilation, both invasive (3.44% 1.34%, 0.001) noninvasive (8.09% 4.51%, intensive care unit (ICU) admission (7.21% 3.9%, 0.001). After multivariate adjustment, increase IHM found 2022 associated (OR 1.22; 95% CI 1.01–1.46). Conclusions: time. severity, ICU IHM. These results can help identify at risk make decisions avoid hospitalization this population.

Язык: Английский

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Protecting patients and peers from healthcare personnel with respiratory viral infections

Infection Control and Hospital Epidemiology, Год журнала: 2025, Номер unknown, С. 1 - 3

Опубликована: Янв. 27, 2025

Язык: Английский

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