Particle and Fibre Toxicology,
Год журнала:
2023,
Номер
20(1)
Опубликована: Фев. 16, 2023
Abstract
Background
A
recent
epidemiological
study
showed
that
air
pollution
is
closely
involved
in
the
prognosis
of
ischemic
stroke.
We
and
others
have
reported
microglial
activation
stroke
plays
an
important
role
neuronal
damage.
In
this
study,
we
investigated
effects
urban
aerosol
exposure
on
neuroinflammation
using
a
mouse
photothrombotic
model.
Results
When
mice
were
intranasally
exposed
to
CRM28,
aerosols
collected
Beijing,
China,
for
7
days,
was
observed
olfactory
bulb
cerebral
cortex.
Mice
CRM28
increased
activity
exacerbation
movement
disorder
after
induction.
Administration
core
particles
stripped
attached
chemicals
from
by
washing
less
suppression
compared
with
CRM28-treated
groups.
did
not
affect
null
aryl
hydrocarbon
receptor,
polycyclic
aromatic
(PAH)
receptor.
Exposure
PM2.5
at
Yokohama,
Japan
also
exacerbated
Conclusion
Particle
matter
aggravation
stroke;
furthermore,
PAHs
particle
could
be
responsible
exacerbation.
Numerous
studies
suggest
that
environmental
exposures
play
a
critical
role
in
Parkinson
disease
(PD)
pathogenesis,
and
large,
population-based
have
the
potential
to
advance
substantially
identification
of
novel
PD
risk
factors.
We
sought
study
nationwide
geographic
relationship
between
air
pollution,
specifically
PM
Advanced Materials,
Год журнала:
2024,
Номер
36(41)
Опубликована: Авг. 19, 2024
Abstract
Efficient
gas
sensors
are
critical
for
environmental
monitoring
and
industrial
safety.
While
metal
oxide
semiconductor
(MOS)
cost‐effective,
they
struggle
with
poor
selectivity,
high
operating
temperatures,
limited
stability.
Electrochemical
sensors,
though
selective
energy‐efficient,
face
costs,
stability
issues
due
to
precious
catalysts
like
platinum
on
carbon
(Pt/C).
Herein,
a
novel,
cost‐effective
electrochemical
sensor
using
nitrogen‐doped
indium
In
2
O
3−
x
N
/3
V
(0.01≤
≤0.14),
synthesized
varying
nitriding
times
is
presented.
The
optimized
3
N‐40
min
demonstrates
remarkable
response
current
of
771
nA
10
ppm
nitrogen
dioxide
(NO
)
at
ambient
temperature,
outstanding
long‐term
(over
30
days)
rapid
response/recovery
(5/16
s).
Compared
Pt/C
it
shows
84%
67%
reductions
in
recovery
times,
respectively,
maintains
98%
performance
after
month,
versus
68%
Pt/C.
This
presents
promising
alternative
sensing,
eliminating
the
need
catalysts.
npj Parkinson s Disease,
Год журнала:
2024,
Номер
10(1)
Опубликована: Янв. 17, 2024
Abstract
Inconsistent
findings
exist
regarding
the
potential
association
between
polluted
air
and
Parkinson’s
disease
(PD),
with
unclear
insights
into
role
of
inherited
sensitivity.
This
study
sought
to
explore
link
various
pollutants
PD
risk,
investigating
whether
genetic
susceptibility
modulates
these
associations.
The
population-based
involved
312,009
initially
PD-free
participants
complete
genotyping
data.
Annual
mean
concentrations
PM
2.5
,
10
NO
2
x
were
estimated,
a
polygenic
risk
score
(PRS)
was
computed
assess
individual
risks
for
PD.
Cox
proportional
models
employed
calculate
hazard
ratios
(HR)
95%
confidence
intervals
(CI)
associations
ambient
pollutants,
incident
Over
median
12.07-year
follow-up,
2356
cases
(0.76%)
observed.
Compared
lowest
quartile
pollution,
highest
quartiles
pollution
showed
HRs
CIs
1.247
(1.089–1.427)
1.201
(1.052–1.373)
incidence,
respectively.
Each
μg/m
3
increase
in
yielded
elevated
1.089
(1.026–1.155)
1.363
(1.043–1.782),
Individuals
significant
exposure
had
development
(HR:
2.748,
CI:
2.145–3.520).
Similarly,
those
substantial
over
twice
as
likely
develop
compared
minimal-risk
counterparts
2.414,
1.912–3.048).
Findings
suggest
that
contaminants
heightens
particularly
individuals
genetically
predisposed
high
susceptibility.
Journal of Parkinson s Disease,
Год журнала:
2024,
Номер
14(3), С. 363 - 381
Опубликована: Апрель 9, 2024
The
brain-
and
body-first
models
of
Lewy
body
disorders
predict
that
aggregated
alpha-synuclein
pathology
usually
begins
in
either
the
olfactory
system
or
enteric
nervous
system.
In
both
scenarios
seems
to
arise
structures
are
closely
connected
outside
world.
Environmental
toxicants,
including
certain
pesticides,
industrial
chemicals,
air
pollution
therefore
plausible
trigger
mechanisms
for
Parkinson’s
disease
dementia
with
bodies.
Here,
we
propose
toxicants
inhaled
through
nose
can
lead
pathological
changes
subsequently
spread
give
rise
a
brain-first
subtype
disease.
Similarly,
ingested
pass
gut
cause
then
extends
via
parasympathetic
sympathetic
pathways
ultimately
produce
subtype.
resulting
be
tracked
by
development
symptoms,
clinical
assessments,
vivo
imaging,
examination.
integration
environmental
exposures
into
generates
testable
hypotheses,
on
prevalence
conditions,
their
future
incidence,
imaging
patterns,
signatures.
proposed
link,
though,
has
limitations
leaves
many
questions
unanswered,
such
as
role
skin,
influence
microbiome,
effects
ongoing
exposures.
Despite
these
limitations,
interaction
exogenous
factors
may
explain
mysteries
open
door
toward
ultimate
goal
–prevention.
Frontiers in Physiology,
Год журнала:
2022,
Номер
13
Опубликована: Фев. 28, 2022
Physical
exercise
(PE)
brings
physiological
benefits
to
human
health;
paradoxically,
exposure
air
pollution
(AP)
is
harmful.
Hence,
the
combined
effects
of
AP
and
PE
are
interesting
issues
worth
exploring.
The
objective
this
study
review
literature
involved
in
AP-PE
fields
perform
a
knowledge-map
analysis
explore
collaborations,
current
hotspots,
applications,
future
perspectives.
Herein,
cluster,
co-citation,
co-occurrence
were
applied
using
CiteSpace
VOSviewer
software.
results
demonstrated
that
domains
have
been
springing
up
rapid
growth
since
21st
century.
Subsequently,
active
countries
institutions
identified,
productive
mainly
located
USA,
China,
UK,
Spain,
Canada.
Developed
seemed
be
major
promoters.
Additionally,
subject
found
environmental
science,
public
health,
sports
medicine
core
subjects,
multidimensional
communications
forming.
Thereafter,
holistic
presentation
reference
co-citation
clusters
was
conducted
discover
research
topics
trace
development
focuses.
Youth,
elite
athletes,
rural
population
regarded
as
noteworthy
subjects.
Commuter
moderate
aerobic
represented
common
context
strategy,
respectively.
Simultaneously,
hotspots
application
elaborated
by
keyword
distribution.
It
noted
adaptations
including
respiratory,
cardiovascular,
metabolic,
mental
health
themes;
oxidative
stress
inflammatory
response
mostly
referred
mechanisms.
Finally,
several
challenges
proposed,
which
beneficial
promote
field.
Molecular
mechanisms
specific
pathways
still
unknown
equilibrium
points
dose-effect
relationships
remain
further
explored.
We
highly
confident
provides
unique
perspective
systematically
comprehensively
pieces
its
related
for
investigations.
Ageing Research Reviews,
Год журнала:
2023,
Номер
86, С. 101867 - 101867
Опубликована: Янв. 28, 2023
The
study
of
pollutant
effects
is
extremely
important
to
address
the
epochal
challenges
we
are
facing,
where
world
populations
increasingly
moving
from
rural
urban
centers,
revolutionizing
our
into
an
world.
These
transformations
will
exacerbate
pollution,
thus
highlighting
necessity
unravel
its
effect
on
human
health.
Epidemiological
studies
have
reported
that
pollution
increases
risk
neurological
diseases,
with
growing
evidence
neurodegenerative
disorders.
Air
and
water
pollutants
main
chemicals
driving
this
risk.
can
promote
inflammation,
acting
in
synergy
genotype
vulnerability.
However,
biological
underpinnings
association
unknown.
In
review,
focus
link
between
brain
network
connectivity
at
macro-scale
level.
We
provide
updated
overview
epidemiological
findings
investigating
changes
associated
exposure,
discuss
mechanistic
insights
pollution-induced
through
neural
networks.
explain,
detail,
pollutome-connectome
axis
might
functional
substrate
for
processes
leading
cognitive
impairment
neurodegeneration.
describe
model
within
framework
two
pollutants,
air
a
widely
recognized
threat,
polyfluoroalkyl
substances,
large
class
synthetic
which
currently
emerging
as
new
neurotoxic
source.
Journal of Movement Disorders,
Год журнала:
2024,
Номер
17(2), С. 127 - 137
Опубликована: Апрель 9, 2024
Mutations
in
the
<i>SNCA</i>
gene,
which
encodes
α-synuclein
(α-syn),
play
a
key
role
development
of
genetic
Parkinson’s
disease
(PD).
α-Syn
is
major
component
Lewy
bodies
PD
and
glial
cytoplasmic
inclusions
multiple
system
atrophy
(MSA).
Rapid
eye
movement
sleep
behavior
disorder
patients
often
progress
to
PD,
dementia
with
bodies,
or
MSA,
are
collectively
known
as
α-synucleinopathies.
The
loss
dopaminergic
neurons
precedes
motor
dysfunction
these
diseases,
but
mechanisms
neurodegeneration
due
α-syn
aggregation
poorly
understood.
Monitoring
vivo
could
serve
diagnostic
biomarker
help
elucidate
pathogenesis,
necessitating
simple
accurate
detection
method.
Seed
amplification
assays
(SAAs),
such
real-time
quaking-induced
conversion
protein
misfolding
cyclic
amplification,
used
detect
small
amounts
abnormally
structured
protofibrils,
central
aggregation.
These
methods
promising
for
early
diagnosis
α-synucleinopathy.
Differences
filament
structures
between
α-synucleinopathies,
observed
through
transmission
electron
microscopy
cryo-electron
microscopy,
suggest
their
pathogenesis
neurodegeneration.
SAAs
may
differentiate
subtypes
α-synucleinopathy
other
diseases.
Efforts
also
being
made
identify
from
blood
using
various
methods.
This
review
introduces
body
fluid
biomarkers
based
on
pathogenic
seeds,
expected
redefine
staging,
improving
clinical
research
accuracy
facilitating
development.
