Particulate matter exposure and neurodegenerative diseases: A comprehensive update on toxicity and mechanisms

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 266, P. 115565 - 115565

Published: Oct. 11, 2023

Exposure to particulate matter (PM) has been associated with a range of health impacts, including neurological abnormalities that affect neurodevelopment, neuroplasticity, and behavior. Recently, there growing interest in investigating the possible relationship between PM exposure onset progression neurodegenerative diseases, such as Alzheimer's disease, Parkinson's Huntington's multiple sclerosis. However, precise mechanism by which affects neurodegeneration is still unclear, even though several epidemiological animal model studies have provided mechanistic insights. This article presents review current research on neurotoxicity its impact diseases. summarizes findings from collected through searches Google Scholar, PubMed, Web Science, Scopus. paper also discusses reported effects central nervous system highlights gaps future directions. The information presented this may inform public policies aimed at reducing contribute development new treatments for Further therapeutic will be needed fully understand

Language: Английский

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Fine Particulate Matter and Parkinson Disease Risk Among Medicare Beneficiaries

Neurology, Journal Year: 2023, Volume and Issue: 101(21)

Published: Oct. 30, 2023

Numerous studies suggest that environmental exposures play a critical role in Parkinson disease (PD) pathogenesis, and large, population-based have the potential to advance substantially identification of novel PD risk factors. We sought study nationwide geographic relationship between air pollution, specifically PM

Language: Английский

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Causal association between long-term exposure to air pollution and incident Parkinson’s disease

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 469, P. 133944 - 133944

Published: March 2, 2024

Language: Английский

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Nitrogen‐Doped Indium Oxide Electrochemical Sensor for Stable and Selective NO₂ Detection

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(41)

Published: Aug. 19, 2024

Abstract Efficient gas sensors are critical for environmental monitoring and industrial safety. While metal oxide semiconductor (MOS) cost‐effective, they struggle with poor selectivity, high operating temperatures, limited stability. Electrochemical sensors, though selective energy‐efficient, face costs, stability issues due to precious catalysts like platinum on carbon (Pt/C). Herein, a novel, cost‐effective electrochemical sensor using nitrogen‐doped indium In 2 O 3− x N /3 V (0.01≤ ≤0.14), synthesized varying nitriding times is presented. The optimized 3 N‐40 min demonstrates remarkable response current of 771 nA 10 ppm nitrogen dioxide (NO ) at ambient temperature, outstanding long‐term (over 30 days) rapid response/recovery (5/16 s). Compared Pt/C it shows 84% 67% reductions in recovery times, respectively, maintains 98% performance after month, versus 68% Pt/C. This presents promising alternative sensing, eliminating the need catalysts.

Language: Английский

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The Body, the Brain, the Environment, and Parkinson’s Disease

Journal of Parkinson s Disease, Journal Year: 2024, Volume and Issue: 14(3), P. 363 - 381

Published: April 9, 2024

The brain- and body-first models of Lewy body disorders predict that aggregated alpha-synuclein pathology usually begins in either the olfactory system or enteric nervous system. In both scenarios seems to arise structures are closely connected outside world. Environmental toxicants, including certain pesticides, industrial chemicals, air pollution therefore plausible trigger mechanisms for Parkinson’s disease dementia with bodies. Here, we propose toxicants inhaled through nose can lead pathological changes subsequently spread give rise a brain-first subtype disease. Similarly, ingested pass gut cause then extends via parasympathetic sympathetic pathways ultimately produce subtype. resulting be tracked by development symptoms, clinical assessments, vivo imaging, examination. integration environmental exposures into generates testable hypotheses, on prevalence conditions, their future incidence, imaging patterns, signatures. proposed link, though, has limitations leaves many questions unanswered, such as role skin, influence microbiome, effects ongoing exposures. Despite these limitations, interaction exogenous factors may explain mysteries open door toward ultimate goal –prevention.

Language: Английский

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Genetic susceptibility modifies the association of long-term air pollution exposure on Parkinson’s disease

npj Parkinson s Disease, Journal Year: 2024, Volume and Issue: 10(1)

Published: Jan. 17, 2024

Abstract Inconsistent findings exist regarding the potential association between polluted air and Parkinson’s disease (PD), with unclear insights into role of inherited sensitivity. This study sought to explore link various pollutants PD risk, investigating whether genetic susceptibility modulates these associations. The population-based involved 312,009 initially PD-free participants complete genotyping data. Annual mean concentrations PM 2.5 , 10 NO 2 x were estimated, a polygenic risk score (PRS) was computed assess individual risks for PD. Cox proportional models employed calculate hazard ratios (HR) 95% confidence intervals (CI) associations ambient pollutants, incident Over median 12.07-year follow-up, 2356 cases (0.76%) observed. Compared lowest quartile pollution, highest quartiles pollution showed HRs CIs 1.247 (1.089–1.427) 1.201 (1.052–1.373) incidence, respectively. Each μg/m 3 increase in yielded elevated 1.089 (1.026–1.155) 1.363 (1.043–1.782), Individuals significant exposure had development (HR: 2.748, CI: 2.145–3.520). Similarly, those substantial over twice as likely develop compared minimal-risk counterparts 2.414, 1.912–3.048). Findings suggest that contaminants heightens particularly individuals genetically predisposed high susceptibility.

Language: Английский

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Physical Exercise in the Context of Air Pollution: An Emerging Research Topic

Frontiers in Physiology, Journal Year: 2022, Volume and Issue: 13

Published: Feb. 28, 2022

Physical exercise (PE) brings physiological benefits to human health; paradoxically, exposure air pollution (AP) is harmful. Hence, the combined effects of AP and PE are interesting issues worth exploring. The objective this study review literature involved in AP-PE fields perform a knowledge-map analysis explore collaborations, current hotspots, applications, future perspectives. Herein, cluster, co-citation, co-occurrence were applied using CiteSpace VOSviewer software. results demonstrated that domains have been springing up rapid growth since 21st century. Subsequently, active countries institutions identified, productive mainly located USA, China, UK, Spain, Canada. Developed seemed be major promoters. Additionally, subject found environmental science, public health, sports medicine core subjects, multidimensional communications forming. Thereafter, holistic presentation reference co-citation clusters was conducted discover research topics trace development focuses. Youth, elite athletes, rural population regarded as noteworthy subjects. Commuter moderate aerobic represented common context strategy, respectively. Simultaneously, hotspots application elaborated by keyword distribution. It noted adaptations including respiratory, cardiovascular, metabolic, mental health themes; oxidative stress inflammatory response mostly referred mechanisms. Finally, several challenges proposed, which beneficial promote field. Molecular mechanisms specific pathways still unknown equilibrium points dose-effect relationships remain further explored. We highly confident provides unique perspective systematically comprehensively pieces its related for investigations.

Language: Английский

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The pollutome-connectome axis: a putative mechanism to explain pollution effects on neurodegeneration

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 86, P. 101867 - 101867

Published: Jan. 28, 2023

The study of pollutant effects is extremely important to address the epochal challenges we are facing, where world populations increasingly moving from rural urban centers, revolutionizing our into an world. These transformations will exacerbate pollution, thus highlighting necessity unravel its effect on human health. Epidemiological studies have reported that pollution increases risk neurological diseases, with growing evidence neurodegenerative disorders. Air and water pollutants main chemicals driving this risk. can promote inflammation, acting in synergy genotype vulnerability. However, biological underpinnings association unknown. In review, focus link between brain network connectivity at macro-scale level. We provide updated overview epidemiological findings investigating changes associated exposure, discuss mechanistic insights pollution-induced through neural networks. explain, detail, pollutome-connectome axis might functional substrate for processes leading cognitive impairment neurodegeneration. describe model within framework two pollutants, air a widely recognized threat, polyfluoroalkyl substances, large class synthetic which currently emerging as new neurotoxic source.

Language: Английский

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Polycyclic aromatic hydrocarbons in urban particle matter exacerbate movement disorder after ischemic stroke via potentiation of neuroinflammation

Particle and Fibre Toxicology, Journal Year: 2023, Volume and Issue: 20(1)

Published: Feb. 16, 2023

Abstract Background A recent epidemiological study showed that air pollution is closely involved in the prognosis of ischemic stroke. We and others have reported microglial activation stroke plays an important role neuronal damage. In this study, we investigated effects urban aerosol exposure on neuroinflammation using a mouse photothrombotic model. Results When mice were intranasally exposed to CRM28, aerosols collected Beijing, China, for 7 days, was observed olfactory bulb cerebral cortex. Mice CRM28 increased activity exacerbation movement disorder after induction. Administration core particles stripped attached chemicals from by washing less suppression compared with CRM28-treated groups. did not affect null aryl hydrocarbon receptor, polycyclic aromatic (PAH) receptor. Exposure PM2.5 at Yokohama, Japan also exacerbated Conclusion Particle matter aggravation stroke; furthermore, PAHs particle could be responsible exacerbation.

Language: Английский

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α-Synuclein: A Promising Biomarker for Parkinson’s Disease and Related Disorders

Journal of Movement Disorders, Journal Year: 2024, Volume and Issue: 17(2), P. 127 - 137

Published: April 9, 2024

Mutations in the <i>SNCA</i> gene, which encodes α-synuclein (α-syn), play a key role development of genetic Parkinson’s disease (PD). α-Syn is major component Lewy bodies PD and glial cytoplasmic inclusions multiple system atrophy (MSA). Rapid eye movement sleep behavior disorder patients often progress to PD, dementia with bodies, or MSA, are collectively known as α-synucleinopathies. The loss dopaminergic neurons precedes motor dysfunction these diseases, but mechanisms neurodegeneration due α-syn aggregation poorly understood. Monitoring vivo could serve diagnostic biomarker help elucidate pathogenesis, necessitating simple accurate detection method. Seed amplification assays (SAAs), such real-time quaking-induced conversion protein misfolding cyclic amplification, used detect small amounts abnormally structured protofibrils, central aggregation. These methods promising for early diagnosis α-synucleinopathy. Differences filament structures between α-synucleinopathies, observed through transmission electron microscopy cryo-electron microscopy, suggest their pathogenesis neurodegeneration. SAAs may differentiate subtypes α-synucleinopathy other diseases. Efforts also being made identify from blood using various methods. This review introduces body fluid biomarkers based on pathogenic seeds, expected redefine staging, improving clinical research accuracy facilitating development.

Language: Английский

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