Particle and Fibre Toxicology,
Год журнала:
2023,
Номер
20(1)
Опубликована: Фев. 16, 2023
Abstract
Background
A
recent
epidemiological
study
showed
that
air
pollution
is
closely
involved
in
the
prognosis
of
ischemic
stroke.
We
and
others
have
reported
microglial
activation
stroke
plays
an
important
role
neuronal
damage.
In
this
study,
we
investigated
effects
urban
aerosol
exposure
on
neuroinflammation
using
a
mouse
photothrombotic
model.
Results
When
mice
were
intranasally
exposed
to
CRM28,
aerosols
collected
Beijing,
China,
for
7
days,
was
observed
olfactory
bulb
cerebral
cortex.
Mice
CRM28
increased
activity
exacerbation
movement
disorder
after
induction.
Administration
core
particles
stripped
attached
chemicals
from
by
washing
less
suppression
compared
with
CRM28-treated
groups.
did
not
affect
null
aryl
hydrocarbon
receptor,
polycyclic
aromatic
(PAH)
receptor.
Exposure
PM2.5
at
Yokohama,
Japan
also
exacerbated
Conclusion
Particle
matter
aggravation
stroke;
furthermore,
PAHs
particle
could
be
responsible
exacerbation.
Environment International,
Год журнала:
2022,
Номер
170, С. 107635 - 107635
Опубликована: Ноя. 16, 2022
Given
the
increasing
burden
of
chronic
conditions,
multimorbidity
is
now
a
priority
for
public
health
systems
worldwide.
However,
relationship
between
household
air
pollution
(HAP)
exposure
with
remains
unclear.We
used
three
waves
data
(2011,
2013,
and
2015)
including
19,295
participants
aged
≥
45
years
from
China
Health
Retirement
Longitudinal
Study,
to
investigate
association
HAP
solid
fuel
use
heating
cooking
risk
multimorbidity.
Multimorbidity
was
defined
as
coexistence
two
or
more
15
diseases
(hypertension,
diabetes,
dyslipidemia,
heart
disease,
stroke,
cardiovascular
lung
asthma,
kidney
liver
digestive
cancer,
psychiatric
memory-related
arthritis).
Multiple
logistic
regression
investigated
cooking,
separately
simultaneously,
Poisson
quasi-likelihood
estimation
explored
whether
could
increase
number
morbidities.
Stratified
analyses
sensitivity
examined
effect
modification
robustness
association.Of
(mean
age:
58.9
years),
40.9
%
have
Compared
who
clean
fuels
higher
in
mixed
(adjusted
odds
ratio,
aOR
=
1.26,
95
%CI:1.16-1.36)
users
(aOR
1.81,
1.67-1.98)
separately.
positively
associated
an
increased
morbidities
β
0.329,
0.290
0.368),
after
controlling
confounders.
Those
living
one-story
building,
poor
cleanliness
No
significant
modifications
those
associations
by
socio-demographic
behaviour
characteristics
observed.HAP
high
Chinese
adults.
Our
findings
provide
important
implications
reducing
disease
restricting
use.
Frontiers in Aging Neuroscience,
Год журнала:
2022,
Номер
14
Опубликована: Июль 26, 2022
Parkinson's
disease
(PD)
is
the
second
most
common
neurodegenerative
after
Alzheimer's
disease,
with
typical
motor
symptoms
as
main
clinical
manifestations.
At
present,
there
are
about
10
million
patients
PD
in
world,
and
its
comorbidities
complications
numerous
incurable.
Therefore,
it
particularly
important
to
explore
pathogenesis
of
find
possible
therapeutic
targets.
Because
etiology
complex,
involving
genes,
environment,
aging,
finding
factors
key
identifying
intervention
Hypoxia
ubiquitous
natural
environment
states,
considered
be
closely
related
PD.
Despite
research
showing
that
hypoxia
increases
expression
aggregation
alpha-synuclein
(α-syn),
pathogenic
protein,
still
a
lack
systematic
studies
on
role
α-syn
pathology
pathogenesis.
Considering
inextricably
linked
various
causes
PD,
may
co-participant
many
aspects
pathologic
process.
In
this
review,
we
describe
risk
for
discuss
inducing
by
these
factors.
Furthermore,
attribute
pathological
changes
caused
oxygen
uptake
disorder
utilization
disorder,
thus
emphasizing
possibility
critical
link
initiating
or
promoting
Our
study
provides
novel
insight
exploring
targets
International Journal of Environmental Research and Public Health,
Год журнала:
2022,
Номер
19(21), С. 14079 - 14079
Опубликована: Окт. 28, 2022
Studies
on
adverse
health
effects
associated
with
air
pollution
mostly
focus
individual
pollutants.
However,
the
is
a
complex
medium,
and
thus
epidemiological
studies
face
many
challenges
limitations
in
multipollutant
approach.
NO2
PM2.5
have
been
selected
as
both
originating
from
combustion
processes
are
considered
to
be
main
pollutants
traffic;
moreover,
elicit
oxidative
stress
responses.
An
answer
question
of
whether
synergistic
or
antagonistic
combined
demonstrated
by
monitored
ambient
not
explicit.
Among
analyzed
studies,
only
few
revealed
statistical
significance.
Exposure
single
pollutant
(PM2.5
NO2)
was
small
increase
non-accidental
mortality
(HR:1.01–1.03).
<10
µg/m3
adjusted
for
well
resulted
slightly
lower
risk
than
pollutant.
In
case
cardiovascular
heart
disease,
evoked
exposure
PM2.5,
respectively,
an
effect
compared
Both
short-
long-term
appearing
higher
respiratory
diseases.
Particle and Fibre Toxicology,
Год журнала:
2023,
Номер
20(1)
Опубликована: Фев. 16, 2023
Abstract
Background
A
recent
epidemiological
study
showed
that
air
pollution
is
closely
involved
in
the
prognosis
of
ischemic
stroke.
We
and
others
have
reported
microglial
activation
stroke
plays
an
important
role
neuronal
damage.
In
this
study,
we
investigated
effects
urban
aerosol
exposure
on
neuroinflammation
using
a
mouse
photothrombotic
model.
Results
When
mice
were
intranasally
exposed
to
CRM28,
aerosols
collected
Beijing,
China,
for
7
days,
was
observed
olfactory
bulb
cerebral
cortex.
Mice
CRM28
increased
activity
exacerbation
movement
disorder
after
induction.
Administration
core
particles
stripped
attached
chemicals
from
by
washing
less
suppression
compared
with
CRM28-treated
groups.
did
not
affect
null
aryl
hydrocarbon
receptor,
polycyclic
aromatic
(PAH)
receptor.
Exposure
PM2.5
at
Yokohama,
Japan
also
exacerbated
Conclusion
Particle
matter
aggravation
stroke;
furthermore,
PAHs
particle
could
be
responsible
exacerbation.