Association between household air pollution from solid fuel use and risk of chronic diseases and their multimorbidity among Chinese adults

Environment International, Год журнала: 2022, Номер 170, С. 107635 - 107635

Опубликована: Ноя. 16, 2022

Given the increasing burden of chronic conditions, multimorbidity is now a priority for public health systems worldwide. However, relationship between household air pollution (HAP) exposure with remains unclear.We used three waves data (2011, 2013, and 2015) including 19,295 participants aged ≥ 45 years from China Health Retirement Longitudinal Study, to investigate association HAP solid fuel use heating cooking risk multimorbidity. Multimorbidity was defined as coexistence two or more 15 diseases (hypertension, diabetes, dyslipidemia, heart disease, stroke, cardiovascular lung asthma, kidney liver digestive cancer, psychiatric memory-related arthritis). Multiple logistic regression investigated cooking, separately simultaneously, Poisson quasi-likelihood estimation explored whether could increase number morbidities. Stratified analyses sensitivity examined effect modification robustness association.Of (mean age: 58.9 years), 40.9 % have Compared who clean fuels higher in mixed (adjusted odds ratio, aOR = 1.26, 95 %CI:1.16-1.36) users (aOR 1.81, 1.67-1.98) separately. positively associated an increased morbidities β 0.329, 0.290 0.368), after controlling confounders. Those living one-story building, poor cleanliness No significant modifications those associations by socio-demographic behaviour characteristics observed.HAP high Chinese adults. Our findings provide important implications reducing disease restricting use.

Язык: Английский

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Hypoxia and Alpha-Synuclein: Inextricable Link Underlying the Pathologic Progression of Parkinson's Disease

Frontiers in Aging Neuroscience, Год журнала: 2022, Номер 14

Опубликована: Июль 26, 2022

Parkinson's disease (PD) is the second most common neurodegenerative after Alzheimer's disease, with typical motor symptoms as main clinical manifestations. At present, there are about 10 million patients PD in world, and its comorbidities complications numerous incurable. Therefore, it particularly important to explore pathogenesis of find possible therapeutic targets. Because etiology complex, involving genes, environment, aging, finding factors key identifying intervention Hypoxia ubiquitous natural environment states, considered be closely related PD. Despite research showing that hypoxia increases expression aggregation alpha-synuclein (α-syn), pathogenic protein, still a lack systematic studies on role α-syn pathology pathogenesis. Considering inextricably linked various causes PD, may co-participant many aspects pathologic process. In this review, we describe risk for discuss inducing by these factors. Furthermore, attribute pathological changes caused oxygen uptake disorder utilization disorder, thus emphasizing possibility critical link initiating or promoting Our study provides novel insight exploring targets

Язык: Английский

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Synergistic or Antagonistic Health Effects of Long- and Short-Term Exposure to Ambient NO2 and PM2.5: A Review

International Journal of Environmental Research and Public Health, Год журнала: 2022, Номер 19(21), С. 14079 - 14079

Опубликована: Окт. 28, 2022

Studies on adverse health effects associated with air pollution mostly focus individual pollutants. However, the is a complex medium, and thus epidemiological studies face many challenges limitations in multipollutant approach. NO2 PM2.5 have been selected as both originating from combustion processes are considered to be main pollutants traffic; moreover, elicit oxidative stress responses. An answer question of whether synergistic or antagonistic combined demonstrated by monitored ambient not explicit. Among analyzed studies, only few revealed statistical significance. Exposure single pollutant (PM2.5 NO2) was small increase non-accidental mortality (HR:1.01–1.03). <10 µg/m3 adjusted for well resulted slightly lower risk than pollutant. In case cardiovascular heart disease, evoked exposure PM2.5, respectively, an effect compared Both short- long-term appearing higher respiratory diseases.

Язык: Английский

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Long-term exposure to particulate air pollution and incidence of Parkinson's disease: A nationwide population-based cohort study in South Korea

Environmental Research, Год журнала: 2022, Номер 212, С. 113165 - 113165

Опубликована: Март 30, 2022

Язык: Английский

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Polycyclic aromatic hydrocarbons in urban particle matter exacerbate movement disorder after ischemic stroke via potentiation of neuroinflammation

Particle and Fibre Toxicology, Год журнала: 2023, Номер 20(1)

Опубликована: Фев. 16, 2023

Abstract Background A recent epidemiological study showed that air pollution is closely involved in the prognosis of ischemic stroke. We and others have reported microglial activation stroke plays an important role neuronal damage. In this study, we investigated effects urban aerosol exposure on neuroinflammation using a mouse photothrombotic model. Results When mice were intranasally exposed to CRM28, aerosols collected Beijing, China, for 7 days, was observed olfactory bulb cerebral cortex. Mice CRM28 increased activity exacerbation movement disorder after induction. Administration core particles stripped attached chemicals from by washing less suppression compared with CRM28-treated groups. did not affect null aryl hydrocarbon receptor, polycyclic aromatic (PAH) receptor. Exposure PM2.5 at Yokohama, Japan also exacerbated Conclusion Particle matter aggravation stroke; furthermore, PAHs particle could be responsible exacerbation.

Язык: Английский

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