What have we learned from genome-wide association studies (GWAS) in Parkinson's disease? DOI Creative Commons
Rubén Fernández‐Santiago, Manu Sharma

Ageing Research Reviews, Journal Year: 2022, Volume and Issue: 79, P. 101648 - 101648

Published: May 18, 2022

After fifteen years of genome-wide association studies (GWAS) in Parkinson's disease (PD), what have we learned? Addressing this question will help catalogue the progress made towards elucidating mechanisms, improving clinical utility identified loci, and envisioning how can harness strides to develop translational GWAS strategies. Here review advances PD date while critically addressing challenges opportunities for next-generation GWAS. Thus, deciphering missing heritability underrepresented populations is currently at reach hand a truly comprehensive understanding genetics across different ethnicities. Moreover, state-of-the-art designs hold true potential enhancing applicability genetic findings, instance, by prediction (PD risk progression). Lastly, advanced alone or combination with environmental parameters, are expected capacity defining patient enriched cohorts stratified profiles readily available neuroprotective trials. Overall, future strategies timely be instrumental providing novel readouts essential translatability findings.

Language: Английский

Unraveling neuroprotection in Parkinson’s disease: Nrf2–Keap1 pathway’s vital role amidst pathogenic pathways DOI
Tanzeer Kaur,

Palak Sidana,

Navpreet Kaur

et al.

Inflammopharmacology, Journal Year: 2024, Volume and Issue: 32(5), P. 2801 - 2820

Published: Aug. 13, 2024

Language: Английский

Citations

6
Association between household air pollution from solid fuel use and risk of chronic diseases and their multimorbidity among Chinese adults DOI Creative Commons
Wenming Shi, Tiantian Zhang,

Yongzhen Li

et al.

Environment International, Journal Year: 2022, Volume and Issue: 170, P. 107635 - 107635

Published: Nov. 16, 2022

Given the increasing burden of chronic conditions, multimorbidity is now a priority for public health systems worldwide. However, relationship between household air pollution (HAP) exposure with remains unclear.We used three waves data (2011, 2013, and 2015) including 19,295 participants aged ≥ 45 years from China Health Retirement Longitudinal Study, to investigate association HAP solid fuel use heating cooking risk multimorbidity. Multimorbidity was defined as coexistence two or more 15 diseases (hypertension, diabetes, dyslipidemia, heart disease, stroke, cardiovascular lung asthma, kidney liver digestive cancer, psychiatric memory-related arthritis). Multiple logistic regression investigated cooking, separately simultaneously, Poisson quasi-likelihood estimation explored whether could increase number morbidities. Stratified analyses sensitivity examined effect modification robustness association.Of (mean age: 58.9 years), 40.9 % have Compared who clean fuels higher in mixed (adjusted odds ratio, aOR = 1.26, 95 %CI:1.16-1.36) users (aOR 1.81, 1.67-1.98) separately. positively associated an increased morbidities β 0.329, 0.290 0.368), after controlling confounders. Those living one-story building, poor cleanliness No significant modifications those associations by socio-demographic behaviour characteristics observed.HAP high Chinese adults. Our findings provide important implications reducing disease restricting use.

Language: Английский

Citations

28
Hypoxia and Alpha-Synuclein: Inextricable Link Underlying the Pathologic Progression of Parkinson's Disease DOI Creative Commons
Mengyuan Guo, Xunming Ji, Jia Liu

et al.

Frontiers in Aging Neuroscience, Journal Year: 2022, Volume and Issue: 14

Published: July 26, 2022

Parkinson's disease (PD) is the second most common neurodegenerative after Alzheimer's disease, with typical motor symptoms as main clinical manifestations. At present, there are about 10 million patients PD in world, and its comorbidities complications numerous incurable. Therefore, it particularly important to explore pathogenesis of find possible therapeutic targets. Because etiology complex, involving genes, environment, aging, finding factors key identifying intervention Hypoxia ubiquitous natural environment states, considered be closely related PD. Despite research showing that hypoxia increases expression aggregation alpha-synuclein (α-syn), pathogenic protein, still a lack systematic studies on role α-syn pathology pathogenesis. Considering inextricably linked various causes PD, may co-participant many aspects pathologic process. In this review, we describe risk for discuss inducing by these factors. Furthermore, attribute pathological changes caused oxygen uptake disorder utilization disorder, thus emphasizing possibility critical link initiating or promoting Our study provides novel insight exploring targets

Language: Английский

Citations

24
Long-term exposure to particulate air pollution and incidence of Parkinson's disease: A nationwide population-based cohort study in South Korea DOI
Hyewon Lee, Ok‐Jin Kim, Jiyun Jung

et al.

Environmental Research, Journal Year: 2022, Volume and Issue: 212, P. 113165 - 113165

Published: March 30, 2022

Language: Английский

Citations

23
What have we learned from genome-wide association studies (GWAS) in Parkinson's disease? DOI Creative Commons
Rubén Fernández‐Santiago, Manu Sharma

Ageing Research Reviews, Journal Year: 2022, Volume and Issue: 79, P. 101648 - 101648

Published: May 18, 2022

After fifteen years of genome-wide association studies (GWAS) in Parkinson's disease (PD), what have we learned? Addressing this question will help catalogue the progress made towards elucidating mechanisms, improving clinical utility identified loci, and envisioning how can harness strides to develop translational GWAS strategies. Here review advances PD date while critically addressing challenges opportunities for next-generation GWAS. Thus, deciphering missing heritability underrepresented populations is currently at reach hand a truly comprehensive understanding genetics across different ethnicities. Moreover, state-of-the-art designs hold true potential enhancing applicability genetic findings, instance, by prediction (PD risk progression). Lastly, advanced alone or combination with environmental parameters, are expected capacity defining patient enriched cohorts stratified profiles readily available neuroprotective trials. Overall, future strategies timely be instrumental providing novel readouts essential translatability findings.

Language: Английский

Citations

23