How COVID-19 shaped mental health: from infection to pandemic effects

Nature Medicine, Год журнала: 2022, Номер 28(10), С. 2027 - 2037

Опубликована: Окт. 1, 2022

Язык: Английский

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Cognition and Memory after Covid-19 in a Large Community Sample

New England Journal of Medicine, Год журнала: 2024, Номер 390(9), С. 806 - 818

Опубликована: Фев. 28, 2024

BackgroundCognitive symptoms after coronavirus disease 2019 (Covid-19), the caused by severe acute respiratory syndrome 2 (SARS-CoV-2), are well-recognized. Whether objectively measurable cognitive deficits exist and how long they persist unclear.MethodsWe invited 800,000 adults in a study England to complete an online assessment of function. We estimated global score across eight tasks. hypothesized that participants with persistent (lasting ≥12 weeks) infection onset would have impairments executive functioning memory be observed such participants, especially those who reported recent poor or difficulty thinking concentrating ("brain fog").ResultsOf 141,583 started assessment, 112,964 completed it. In multiple regression analysis, had recovered from Covid-19 whom resolved less than 4 weeks at least 12 similar small cognition as compared no–Covid-19 group, not been infected SARS-CoV-2 unconfirmed (−0.23 SD [95% confidence interval {CI}, −0.33 −0.13] −0.24 CI, −0.36 −0.12], respectively); larger group were seen unresolved (−0.42 SD; 95% −0.53 −0.31). Larger during periods which original virus B.1.1.7 variant was predominant later variants (e.g., −0.17 for vs. B.1.1.529 variant; −0.20 −0.13) hospitalized intensive care unit admission, −0.35 −0.49 −0.20). Results analyses propensity-score–matching analyses. comparison memory, reasoning, function tasks associated largest (−0.33 SD); these correlated weakly symptoms, including brain fog. No adverse events reported.ConclusionsParticipants measured shorter-duration although short-duration still recovery. Longer-term persistence any clinical implications remain uncertain. (Funded National Institute Health Care Research others.)

Язык: Английский

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Association of cerebrospinal fluid brain-binding autoantibodies with cognitive impairment in post-COVID-19 syndrome

Brain Behavior and Immunity, Год журнала: 2023, Номер 109, С. 139 - 143

Опубликована: Янв. 16, 2023

Neurological symptoms, in particular cognitive deficits, are common post-COVID-19 syndrome (PCS). There is no approved therapy available, and the underlying disease mechanisms largely unknown. Besides others, autoimmune processes may play a key role.We here present data of prospective study conducted between September 2020 December 2021 performed at two German University hospitals with specialized Neurology outpatient clinics. Fifty patients self-reported deficits as main complaint PCS available serum CSF samples were included. Cell-based assays indirect immunofluorescence on murine brain sections used to detect autoantibodies against intracellular surface antigens analyzed for associations screening assessment.Clearly abnormal status (MoCA ≤ 25/30 points) was only seen 18/50 deficits. Most (46/50) had normal routine parameters. anti-neuronal found 52 % all patients: n = 9 only, 3 14 both, including those myelin, Yo, Ma2/Ta, GAD65 NMDA receptor, but also variety undetermined epitopes sections. These included cerebral vessel endothelium, Purkinje neurons, granule cells, axon initial segments, astrocytic proteins neuropil basal ganglia or hippocampus well formerly unknown perinuclear rim pattern. Pathological MoCA results associated presence antibodies (p 0.0004).Autoantibodies targeting strongly associate pathological tests, when CSF. Several autoantigens still await experimental identification. Further research needed inform clinical relevance these autoantibodies, controlled studies that explore potential efficacy antibody-depleting immunotherapy PCS.

Язык: Английский

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Effects of COVID-19 on cognition and brain health

Trends in Cognitive Sciences, Год журнала: 2023, Номер 27(11), С. 1053 - 1067

Опубликована: Авг. 30, 2023

COVID-19 is associated with a range of neurological, cognitive, and mental health symptoms both acutely chronically that can persist for many months after infection in people long-COVID syndrome. Investigations cognitive function neuroimaging have begun to elucidate the nature some these symptoms. They reveal that, although deficits may be related brain imaging abnormalities people, also occur absence objective or changes. Furthermore, impairment detected even asymptomatic individuals. We consider evidence regarding symptoms, deficits, neuroimaging, as well their possible underlying mechanisms.

Язык: Английский

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Cognitive impairments among patients in a long-COVID clinic: Prevalence, pattern and relation to illness severity, work function and quality of life

Journal of Affective Disorders, Год журнала: 2022, Номер 324, С. 162 - 169

Опубликована: Дек. 28, 2022

A considerable proportion of people experience lingering symptoms after Coronavirus Disease 2019 (COVID-19). The aim this study was to investigate the frequency, pattern and functional implications cognitive impairments in patients at a long-COVID clinic who were referred hospitalisation with COVID-19 or by their general practitioner.Patients underwent screening completed questionnaires regarding subjective cognition, work function quality life. Patients' performance compared that 150 age-, sex-, education-matched healthy controls (HC) individually expected calculated based on age, sex education.In total, 194 assessed, average 7 months (standard deviation: 4) acute COVID-19.44-53 % displayed clinically relevant HC performance, respectively. Moderate large seen global cognition working memory executive function, while mild moderate occurred verbal fluency, learning memory. Hospitalised (n = 91) non-hospitalised 103) showed similar degree analyses adjusted for age time since illness. Patients cognitively impaired group older, more often hospitalised, had higher BMI frequent asthma, female. More objective impairment associated difficulties, poorer lower life.The cross-sectional, which precludes causality inferences.These findings underscore need assess treat clinics.

Язык: Английский

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Associations of subjective and objective cognitive functioning after COVID-19: A six-month follow-up of ICU, ward, and home-isolated patients

Brain Behavior & Immunity - Health, Год журнала: 2023, Номер 27, С. 100587 - 100587

Опубликована: Янв. 5, 2023

Subjective and objective cognitive dysfunction are reported after COVID-19 but with limited data on their congruence associations the severity of acute disease. The aim this cohort study is to describe prevalence subjective at three six months symptoms psychological disease-related factors.We assessed a 184 patients COVID-19: 82 admitted Intensive Care Unit (ICU), 53 regular hospital wards, 49 isolated home. A non-COVID control group individuals was included. Demographic clinical were collected. symptoms, impairment, depressive post-traumatic stress disorder (PTSD) assessed.At months, impairment by 32.3% ICU-treated, 37.3% ward-treated, 33.3% home-isolated observed in 36.1% 34.7% 8.9% patients. associated PTSD female sex, not assessment or metrics.One-third patients, regardless disease severity, high levels which results from screening demographic factors. Our stresses importance thorough reporting long-term for underlying mental health related factors such as depression.

Язык: Английский

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Neuropsychiatric disorders following SARS-CoV-2 infection

Brain, Год журнала: 2023, Номер 146(6), С. 2241 - 2247

Опубликована: Фев. 2, 2023

Abstract Several large-scale electronic health records studies have reported increased diagnostic rates for neuropsychiatric disorders following Coronavirus disease 2019 [COVID-19 or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 infection)], but many questions remain. To highlight the issues, we selectively review this literature, focusing on mood disorder, anxiety psychotic and cognitive impairment (‘brain fog’). Eight key are addressed, comprising: (i) nature magnitude of risks; (ii) their association with severity infection; (iii) duration; (iv) whether risks differ between adults children, men women; (v) prior vaccination protects against them; (vi) risk profile associated different SARS-CoV-2 strains; (vii) what underlying mechanisms might be; (viii) sequelae can be predicted. We consider major unknowns, limitations research in area, use additional approaches to help characterize understand burden COVID-19.

Язык: Английский

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COVID-19 and Risk for Mental Disorders Among Adults in Denmark

JAMA Psychiatry, Год журнала: 2023, Номер 80(8), С. 778 - 778

Опубликована: Май 24, 2023

Psychiatric outcomes after COVID-19 have been of high concern during the pandemic; however, studies on a nationwide level are lacking.

Язык: Английский

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Long term neuropsychiatric consequences in COVID-19 survivors: Cognitive impairment and inflammatory underpinnings fifteen months after discharge

Asian Journal of Psychiatry, Год журнала: 2022, Номер 80, С. 103409 - 103409

Опубликована: Дек. 15, 2022

Язык: Английский

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Cognitive Assessment in SARS-CoV-2 Patients: A Systematic Review

Frontiers in Aging Neuroscience, Год журнала: 2022, Номер 14

Опубликована: Июль 1, 2022

Background Patients with post-infective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) often show both short- and long-term cognitive deficits within the dysexecutive/inattentive spectrum. However, little is known about which alterations are commonly found in patients recovered from SARS-CoV-2, psychometric tools clinicians should consider when assessing cognition this population. The present work reviewed published studies to provide a critical narrative of neuropsychological (NPs) observed after SARS-CoV-2 infection tests most suited for detecting such sequelae depending on illness severity. Methods This review followed Preferred Reporting Items Systematic reviews Meta-Analyses (PRISMA) guidelines was pre-registered Prospective Register Reviews (PROSPERO) (CRD42021253079). Observational quantitatively were considered. From 711 retrieved articles, 19 conducted without medical comorbidities included stratified by disease Results majority ( N = 13) adopted first-level tests. frequently administered screeners Montreal Cognitive Assessment (MoCA) Mini-Mental State Examination (MMSE)—with former more likely detect mild, latter moderate/severe deficits. Among second-level tests, those attention executive functions (EFs) highly represented. Remotely-delivered yielded lower percentages impairment. Overall, domains be impaired EFs, attention, memory. Conclusion can detected NPs testing. Depending test features, likelihood observing vary. Further larger sample sizes needed investigate clinical usefulness tools. primary goal preventative health services early detection intervention emerging

Язык: Английский

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