Editorial: Cognitive and mental health improvement under- and post-COVID-19

Frontiers in Psychology, Год журнала: 2025, Номер 16

Опубликована: Март 6, 2025

Being infected by COVID-19 represents a major psychological stressor, with the virus itself exerting direct biological effects that may contribute to cognitive and mental health challenges. In retrospective study conducted in Brazil, Bonfim et al reported 24% of 630 outpatients, confirmed positive between December 2020 March 2022, exhibited symptoms. These symptoms ranged from difficulties attention memory impaired thinking. Depression, fatigue, female gender were identified as risk factors for these Similarly, Li surveying 482 patients China 2022 June 2023, found 13% experienced depression, 27% anxiety, 25% stress. The severity long-term COVID correlated poorer outcomes, while resilience social support emerged protective factors.While infection-control measures have been effective limiting spread virus, they often come at cost health. For example, Barbalat nationwide online survey during France's first lockdown (March-May 2020), involving approximately 19,000 participants. They observed gradual decline over course lockdown, psychiatric conditions concerns about access equipment serving factors. Conversely, optimism pandemic's trajectory, neighborhood support, participation collective actions Qing examined impact campus lockdowns on Chinese university students elevated levels stress depression compared pre-lockdown periods. Using latent class mixed models, authors distinct trajectories unfavorable peer relationships more likely experience trajectories.Healthcare professionals, frequently exposed heavy workloads, high challenges pandemic 15 . Zhu surveyed 145 members medical security team Winter Olympic Games Paralympics longer work durations associated worse including higher anxiety. Females particularly vulnerable. Such findings underscore unique pressures faced frontline workers public crises. extends beyond physical well-being motivation. Vega-Fernández al, 161 Chilean school teachers late 2021, 98% musculoskeletal disorders past year. quality life. this study, females also disorders. Tang & He college depressive showed reduced academic engagement, highlighting broader motivational consequences struggles.As become milder restrictions relaxed, new emerged. Hao after eased its control January one five individuals over-concern characterized obsessive thoughts anxiety regarding infection. Poor self-rated worries family contracting over-concerns. Cheng 2,000 healthcare professionals shortly relaxations, half gender, younger age, low professional rank, working hours another Jiang further suggested reciprocal problems job burnout period.Despite general decrease infection isolation winds down, studies indicate loneliness, heightened stringent quarantine measures, has not fully returned pre-pandemic 13,14 de Vroege van dex Broek 510 improvements work-life balance reductions complaints postpandemic earlier stages. However, 36% increased 21% depression. Wang, Zhang, noted four 2023 levels. emphasize importance ongoing monitoring tailored care, even subsides. Not all outcomes negative. Some demonstrated posttraumatic growth, deeper appreciation life meaningful interpersonal relationships. Zeng 39% resident physicians growth. Satisfaction income sufficient workplace key highlight potential foster growth offer pathway improved outcomes.Female gender. A consistent factor above mentioned is being (Bonfim al). This difference finding; epidemiological long are developing disorders, 16 17 Several mechanisms proposed explain vulnerability. instance, severe forms adverse childhood experiences, predisposing them 18 Moreover, engage rumination (i.e., repetitive passive focus negative emotional experiences) 19 exhibit risk-aversive behaviors situations 20 less intense activity 21 , which benefits 22,23 Another explanation highlighted Sasaki who investigated role emotion malleability beliefs. Their suggest hold fixed beliefs cannot or change their emotions. linked distress prevalent among women, those under 45 years old, Social support. extensive evidence 24,25 crucial factor. addition Shi lower enhance perceived control, lack could lead sense helplessness, development states 26 Perceived promotes problem-focused coping strategies help address stressors, maladaptive strategies, such avoidance, rumination, suppression, increase psychopathology 27 .Self-control. Self-control appeared an important correlation self-control irritability students. network analysis, impulse bridge symptoms, resistance temptation acted Self-control, enables manage emotions, behaviors, thoughts, determinant 28 29 .Leisure engagement. self-control, active leisure engagement against Kulbin using profile categorized 439 Estonia adults into based changes coping. participants healthiest exercise, spending time nature, pursuing hobbies. activities known promote (see next section) [30][31][32] .Together, multifaceted approach well-being, combining psychological, behavioral, mitigate psychopathology.The current collection offers valuable insights various intervention health.Physical exercise. Tian, Luo systematic review meta-analysis assess exercise interventions Based 12 studies, estimated effect size follows: standardized mean (SMD) =-1.02 (95% CI: -1.42 -0.62); SMD = -0.81 -1.10 -0.52); stress, -1.05 -1.33 -0.78). greatest single sessions lasting 30-40 minutes frequency 3-5 times per week. align supporting regular [21][22][23][31][32][33][34][35] behind include release neurotrophic factors, endorphins, endocannabinoids, along activation dopamine serotonin neurotransmitter systems 22,23,[35][36][37] .Nature contact. Patwary outdoors green spaces significantly health, reducing finding growing interest nature horticultural therapy [38][39][40][41][42] contact relaxation brain, well endocrine immune Furthermore, engaging interactions, loneliness enhancing 43 .Mindfulness. Melvin qualitative, interpretative phenomenological analysis facilitators mindfulness program pandemic. Mindfulness practices, meditation yoga, shown alleviate body awareness, attention, regulation, facilitating perspective shifts clarifying values 44,45 both delivering programs online, providing future programs.Wong evaluated 8-week smartphone-delivered multicomponent lifestyle medicine through randomized controlled trial nonclinical sample. combined changes, healthy eating, practices like yoga. While no focused solely nutrition, supports critical nutrition proper brain function 46,47 combination expected synergistic effects. Wong overall insomnia, sizes ranging 0.13 0.56 (Cohen's d). Notably, persisted 1-month follow-up.Light therapy. Chen light adolescents young adults. were: SMD=-2.1 -2.5 -1.68) concurrent medications, SMD=-1.03 -1.27 -0.78) without medications. Light thought reset altered circadian seasonal rhythms 48 performed additional analyses determine optimal dosing guidelines, clinical applications.We hope Research Topic offered perspectives exacerbated them. intricate interplay shaping outcomes. calls holistic combines individual systemic care strengthened community By addressing issues collaborative interdisciplinary approach, we can transform lessons improve generations. We inspires research, innovation, policy meet

Язык: Английский

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Effects of COVID-19 on cognition and brain health

Trends in Cognitive Sciences, Год журнала: 2023, Номер 27(11), С. 1053 - 1067

Опубликована: Авг. 30, 2023

COVID-19 is associated with a range of neurological, cognitive, and mental health symptoms both acutely chronically that can persist for many months after infection in people long-COVID syndrome. Investigations cognitive function neuroimaging have begun to elucidate the nature some these symptoms. They reveal that, although deficits may be related brain imaging abnormalities people, also occur absence objective or changes. Furthermore, impairment detected even asymptomatic individuals. We consider evidence regarding symptoms, deficits, neuroimaging, as well their possible underlying mechanisms.

Язык: Английский

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Neurovascular coupling impairment as a mechanism for cognitive deficits in COVID-19

Brain Communications, Год журнала: 2024, Номер 6(2)

Опубликована: Янв. 1, 2024

Abstract Components that comprise our brain parenchymal and cerebrovascular structures provide a homeostatic environment for proper neuronal function to ensure normal cognition. Cerebral insults (e.g. ischaemia, microbleeds infection) alter cellular physiologic processes within the neurovascular unit contribute cognitive dysfunction. COVID-19 has posed significant complications during acute convalescent stages in multiple organ systems, including brain. Cognitive impairment is prevalent complication patients, irrespective of severity SARS-CoV-2 infection. Moreover, overwhelming evidence from vitro, preclinical clinical studies reported SARS-CoV-2-induced pathologies components are associated with impairment. Neurovascular disruption alters coupling response, critical mechanism regulates cerebromicrovascular blood flow meet energetic demands locally active neurons. Normal processing achieved through response involves coordinated action cells (i.e. neurons glia) cell types endothelia, smooth muscle pericytes). However, current work on COVID-19-induced yet investigate as causal factor. Hence, this review, we aim describe SARS-CoV-2's effects how they can impact decline disease. Additionally, explore potential therapeutic interventions mitigate Given great both individuals public health, necessity effort fundamental scientific research application becomes imperative. This integrated endeavour crucial mitigating deficits induced by its subsequent burden especially vulnerable population.

Язык: Английский

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Neurobiology of COVID‐19‐Associated Psychosis/Schizophrenia: Implication of Epidermal Growth Factor Receptor Signaling

Neuropsychopharmacology Reports, Год журнала: 2025, Номер 45(1)

Опубликована: Янв. 4, 2025

ABSTRACT COVID‐19 exhibits not only respiratory symptoms but also neurological/psychiatric rarely including delirium/psychosis. Pathological studies on provide evidence that the cytokine storm, in particular (epidermal growth factor) EGF receptor (EGFR, ErbB1, Her1) activation, plays a central role progression of viral replication and lung fibrosis. Of note, SARS‐CoV‐2 virus (specifically, S1 spike domain) mimics directly transactivates EGFR, preceding inflammatory process. In agreement, anticancer drugs targeting EGFR such as Nimotuzumab tyrosine kinase inhibitors are markedly effective COVID‐19. However, these data might raise provisional caution regarding implication psychiatric disorder schizophrenia. The author's group has been investigating etiologic neuropathologic associations signaling with There significant molecular between schizophrenia ligand levels blood well brain. addition, perinatal challenges ligands intraventricular administration to rodents monkeys both resulted severe behavioral and/or electroencephalographic endophenotypes relevant this disorder. These animal models display postpubertal abnormality soliloquy‐like self‐vocalization intercortical functional connectivity. Here, we discuss neuropsychiatric coronavirus infection its interaction system, by searching related literatures PubMed database end 2023.

Язык: Английский

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Genetic risk factors for severe and fatigue dominant long COVID and commonalities with ME/CFS identified by combinatorial analysis

Journal of Translational Medicine, Год журнала: 2023, Номер 21(1)

Опубликована: Ноя. 1, 2023

Long COVID is a debilitating chronic condition that has affected over 100 million people globally. It characterized by diverse array of symptoms, including fatigue, cognitive dysfunction and respiratory problems. Studies have so far largely failed to identify genetic associations, the mechanisms behind disease, or any common pathophysiology with other conditions such as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) present similar symptoms.We used combinatorial analysis approach combinations variants significantly associated development long examine biological underpinning its various symptoms. We compared two subpopulations patients from Sano Genetics' GOLD study cohort, focusing on severe dominant phenotypes. evaluated signatures previously identified in an ME/CFS population against this understand similarities disorders may be triggered prior viral infection. Finally, we also output known associations diseases, range metabolic neurological disorders, overlap pathophysiological mechanisms.Combinatorial 73 genes were highly at least one populations included analysis. Of these, 9 acute COVID-19, 14 differentially expressed transcriptomic patients. A pathway enrichment revealed pathways most mainly aligned cardiometabolic diseases. Expanded genotype suggests specific SNX9 genotypes are significant contributor risk protection infection, but gene-disease relationship context dependent mediated interactions KLF15 RYR3. Comparison uniquely Severe Fatigue Dominant differences between enriched each subgroup. The unique immune myeloid differentiation macrophage foam cells. Genes subgroup MAPK/JNK signaling. ME/CFS, several involved circadian rhythm regulation insulin regulation. Overall, 39 SNPs can linked recent patient UK Biobank. Among COVID, 42 potentially tractable for novel drug discovery approaches, 13 these already targeted drugs clinical pipelines. From example, TLR4 antagonists repurposing candidates potential protect term impairment pathology caused SARS-CoV-2. currently evaluating targets use treating and/or ME/CFS.This demonstrates power analytics stratifying heterogeneous complex diseases do not simple monogenic etiologies. These results build upon findings analyses COVID-19 expect access additional independent, larger datasets will further improve disease insights validate treatment options COVID.

Язык: Английский

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Tracking cognitive trajectories in older survivors of COVID-19 up to 2.5 years post-infection

Nature Aging, Год журнала: 2024, Номер 4(9), С. 1186 - 1193

Опубликована: Июль 10, 2024

Язык: Английский

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A Comprehensive Review of Neurodegenerative Manifestations of SARS-CoV-2

Vaccines, Год журнала: 2024, Номер 12(3), С. 222 - 222

Опубликована: Фев. 21, 2024

The World Health Organization reports that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has impacted a staggering 770 million individuals to date. Despite the widespread nature of this viral infection, its precise effects remain largely elusive. This scientific inquiry aims shed light on intricate interplay between SARS-CoV-2 infection and development neurodegenerative disorders-an affliction weighs heavily millions worldwide stands as fourth most prevalent cause mortality. By comprehensively understanding repercussions disorders, we strive unravel critical insights can potentially shape our approach diagnosis, prevention, treatment these debilitating conditions. To achieve goal, conducted comprehensive literature review data available date showing is associated with increased risk severity well altered expression key genes pathways involved in their pathogenesis.

Язык: Английский

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Risks of neurological and psychiatric sequelae 2 years after hospitalisation or intensive care admission with COVID-19 compared to admissions for other causes

Brain Behavior and Immunity, Год журнала: 2023, Номер 112, С. 85 - 95

Опубликована: Май 30, 2023

The association between COVID-19 and subsequent neurological psychiatric disorders is well established. However, two important questions remain unanswered. First, what are the risks in those admitted to intensive care unit (ICU) with COVID-19? Admission ICU itself associated sequelae it not clear whether further increases or changes their profile. Second, trajectories of patients hospital COVID-19, when do subside? We sought answer these using a retrospective cohort study based on electronic health records (EHR) data from TriNetX Analytics Network (covering 89 million patients, mostly USA). Cohorts were propensity score-matched (for 82 covariates capturing risk factors for more severe illness) (respectively) any other reason. Matched cohorts followed up years 14 outcomes compared. A total 280,173 46,573 successfully matched an equal number Those hospitalised found be at greater range including seizure/epilepsy, encephalitis, myoneural junction/muscle disease, Guillain-Barré syndrome (GBS), dementia, cognitive deficits, psychotic disorder, mood anxiety disorders, but ischaemic stroke intracranial haemorrhage. When elevated after most remained so whole follow-up (except disorders). Risk profiles substantially different among ICU: compared reasons, GBS, deficits significantly lower stroke, haemorrhage, disorder. elevated, short-lived. In summary, wide ranging long standing whereas similar to, than, observed post-ICU admission cause. These contrasting relevant researchers, clinicians, policymakers.

Язык: Английский

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Reproducibility of Genetic Risk Factors Identified for Long COVID using Combinatorial Analysis Across US and UK Patient Cohorts with Diverse Ancestries

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Фев. 6, 2025

Abstract Background Long COVID is a major public health burden causing diverse array of debilitating symptoms in tens millions patients globally. In spite this overwhelming disease prevalence and staggering cost, its severe impact on patients’ lives intense global research efforts, study the has proved challenging due to complexity. Genome-wide association studies (GWAS) have identified only four loci potentially associated with disease, although these results did not statistically replicate between studies. A previous combinatorial analysis total 73 genes that were highly two long cohorts predominantly (>91%) white European ancestry Sano GOLD population, we sought reproduce findings independent ancestrally more All Us (AoU) population. Methods We assessed reproducibility 5,343 signatures from original AoU Because very small population sizes provide limited power findings, initially tested whether observed significant enrichment are also positively correlated cohort after controlling for substructure. Results For case frequency greater than 5% AoU, consistently (77% - 83%, p < 0.01) cohort. These encompassed 92% study. At least five found shown be individually significantly increased Rates signature strongest among self-identified patients, but observe reproducing associations black/African-American Hispanic/Latino cohorts. Signatures 11 out 13 drug repurposing candidates reproduced Conclusion demonstrate signal by analysis, broadly validating analysis. They compelling evidence much broader genetic previously through traditional GWAS This strongly supports hypothesis factors play critical role determining an individual’s susceptibility following recovery acute SARS-CoV-2 infection. It lends weight Together may help stimulate needed new precision medicine approaches effectively diagnose treat disease. first reproduction across multiple populations substantially different distributions. Given high rate populations, clinical application promote better equity. hope will confidence explore some mechanisms targets advance into novel ways accelerate discovery selection therapeutic options, both form newly discovered drugs and/or immediate prioritization coordinated investigations efficacy repurposed candidates.

Язык: Английский

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Neurocognitive Impairment in Post-COVID-19 Condition in Adults: Narrative Review of the Current Literature

Archives of Clinical Neuropsychology, Год журнала: 2024, Номер 39(3), С. 276 - 289

Опубликована: Март 22, 2024

Abstract The severe acute respiratory syndrome coronavirus 2 virus has, up to the time of this article, resulted in &gt;770 million cases COVID-19 illness worldwide, and approximately 7 deaths, including &gt;1.1 United States. Although defined as a virus, early pandemic, it became apparent that considerable numbers people recovering from experienced persistence or new onset multi-system health problems, neurologic cognitive behavioral concerns. Persistent problems are Post-COVID-19 Condition (PCC), Post-Acute Sequelae COVID-19, Long COVID. A significant number those with PCC report problems. This paper reviews current state scientific knowledge on persisting symptoms adults following illness. brief history is provided emergence concerns about definition PCC. Methodologic factors complicate clear understanding reviewed. review then examines research patterns impairment have been found, may contribute increased risk, variables, interventions being used ameliorate symptoms. Finally, recommendations made ways neuropsychologists can improve quality existing research.

Язык: Английский

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