Cancer metabolites: promising biomarkers for cancer liquid biopsy

Biomarker Research, Год журнала: 2023, Номер 11(1)

Опубликована: Июнь 30, 2023

Abstract Cancer exerts a multitude of effects on metabolism, including the reprogramming cellular metabolic pathways and alterations in metabolites that facilitate inappropriate proliferation cancer cells adaptation to tumor microenvironment. There is growing body evidence suggesting aberrant play pivotal roles tumorigenesis metastasis, have potential serve as biomarkers for personalized therapy. Importantly, high-throughput metabolomics detection techniques machine learning approaches offer tremendous clinical oncology by enabling identification cancer-specific metabolites. Emerging research indicates circulating great promise noninvasive detection. Therefore, this review summarizes reported abnormal cancer-related last decade highlights application liquid biopsy, specimens, technologies, methods, challenges. The provides insights into promising tool applications.

Язык: Английский

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Recent Advances in Cellular Signaling Interplay between Redox Metabolism and Autophagy Modulation in Cancer: An Overview of Molecular Mechanisms and Therapeutic Interventions

Antioxidants, Год журнала: 2023, Номер 12(2), С. 428 - 428

Опубликована: Фев. 9, 2023

Autophagy is a fundamental homeostatic process in which certain cellular components are ingested by double-membrane autophagosomes and then degraded to create energy or maintain homeostasis survival. It typically observed nutrient-deprived cells as survival mechanism. However, it has also been identified crucial maintaining disease progression. Normal metabolism produces reactive oxygen (ROS) nitrogen species at low levels. increased production causes oxidative stress, can lead diabetes, cardiovascular diseases, neurological disorders, cancer. was recently shown that redox equilibrium via autophagy critical for responses stress. little understood about the molecular cancer processes connect control of autophagy. In cells, oncogenic mutations, carcinogens, metabolic reprogramming cause ROS generation Recent studies have suggested activates pathways promote development metastasis. Moreover, relationship between programming involved malignant phenotype. Currently, while signaling events governing how affects cascades well understood, very known related this review, we focus on current knowledge modulation role further stress progression regulation. Therefore, review focuses understanding oxidation/reduction fine-tune help understand govern cancer, either leading cell death strategies

Язык: Английский

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Reprogramming of Lipid Metabolism Mediates Crosstalk, Remodeling, and Intervention of Microenvironment Components in Breast Cancer

International Journal of Biological Sciences, Год журнала: 2024, Номер 20(5), С. 1884 - 1904

Опубликована: Янв. 1, 2024

Due to the unique characteristics of breast cancer initiation sites and significant alterations in tumor metabolism, cells rely on lipid metabolic reprogramming effectively regulate programs during disease progression cascade.This adaptation enables them meet energy demands required for proliferation, invasion, metastasis, responses signaling molecules microenvironment.In this review, we comprehensively examined distinctive features elucidated underlying mechanisms driving aberrant behavior cells.Additionally, emphasize potential role adaptive changes metabolism within microenvironment, while summarizing recent preclinical studies.Overall, precise control over rewiring understanding plasticity microenvironment hold promising implications developing targeted treatment strategies against disease.Therefore, interventions targeting may facilitate innovative advancements clinical applications.

Язык: Английский

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Comprehensive analysis of nicotinamide metabolism-related signature for predicting prognosis and immunotherapy response in breast cancer

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Март 8, 2023

Background Breast cancer (BC) is the most common malignancy among women. Nicotinamide (NAM) metabolism regulates development of multiple tumors. Herein, we sought to develop a NAM metabolism-related signature (NMRS) make predictions survival, tumor microenvironment (TME) and treatment efficacy in BC patients. Methods Transcriptional profiles clinical data from The Cancer Genome Atlas (TCGA) were analyzed. genes (NMRGs) retrieved Molecular Signatures Database. Consensus clustering was performed on NMRGs differentially expressed between different clusters identified. Univariate Cox, Lasso, multivariate Cox regression analyses sequentially conducted (NMRS), which then validated International Consortium (ICGC) database Gene Expression Omnibus (GEO) single-cell RNA-seq data. Further studies, such as gene set enrichment analysis (GSEA), ESTIMATE, CIBERSORT, SubMap, Immunophenoscore (IPS) algorithm, cancer-immunity cycle (CIC), mutation burden (TMB), drug sensitivity assess TME response. Results We identified 6-gene NMRS that significantly associated with prognosis an independent indicator. risk stratification according low-risk group showed preferable outcomes ( P < 0.001). A comprehensive nomogram developed excellent predictive value for prognosis. GSEA demonstrated predominantly enriched immune-associated pathways, whereas high-risk cancer-related pathways. ESTIMATE CIBERSORT algorithms revealed had higher abundance anti-tumor immunocyte infiltration 0.05). Submap, IPS, CIC, TMB, external immunotherapy cohort (iMvigor210) indicative better response Conclusions novel offers promising way evaluate patients, may facilitate practice management.

Язык: Английский

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Advancements in understanding the role and mechanism of sirtuin family (SIRT1-7) in breast cancer management

Biochemical Pharmacology, Год журнала: 2025, Номер 232, С. 116743 - 116743

Опубликована: Янв. 4, 2025

Язык: Английский

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Recent Advances on the Role of B Vitamins in Cancer Prevention and Progression

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(5), С. 1967 - 1967

Опубликована: Фев. 25, 2025

Water-soluble B vitamins, mainly obtained through dietary intake of fruits, vegetables, grains, and dairy products, act as co-factors in various biochemical processes, including DNA synthesis, repair, methylation, energy metabolism. These vitamins include B1 (Thiamine), B2 (Riboflavin), B3 (Niacin), B5 (Pantothenic Acid), B6 (Pyridoxine), B7 (Biotin), B9 (Folate), B12 (Cobalamin). Recent studies have shown that besides their fundamental physiological roles, influence oncogenic metabolic pathways, glycolysis (Warburg effect), mitochondrial function, nucleotide biosynthesis. Although deficiencies these are associated with several complications, emerging evidence suggests excessive specific may also contribute to cancer progression interfere therapy due impaired genetic functions. This review discusses the tumor-suppressive tumor-progressive roles cancer. It explores recent on a comprehensive understanding relationship between vitamin metabolism underscores need for further research determine optimal balance prevention therapy.

Язык: Английский

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Updates on Triple-Negative Breast Cancer in Type 2 Diabetes Mellitus Patients: From Risk Factors to Diagnosis, Biomarkers and Therapy

Diagnostics, Год журнала: 2023, Номер 13(14), С. 2390 - 2390

Опубликована: Июль 17, 2023

Triple-negative breast cancer (TNBC) is usually the most malignant and aggressive mammary epithelial tumor characterized by lack of expression for estrogen receptors progesterone receptors, absence epidermal growth factor receptor (HER)2 amplification. Corresponding to 15–20% all cancers well-known its poor clinical outcome, this negative deprives TNBC from targeted therapy makes management therapeutically challenging. Type 2 diabetes mellitus (T2DM) common ageing metabolic disorder due insulin deficiency or resistance resulting in hyperglycemia, hyperinsulinemia, hyperlipidemia. Due hormonal imbalances, there are many interplays between both chronic disorders leading increased risk cancer, especially TNBC, diagnosed T2DM patients. The purpose review provide up-to-date information related epidemiology clinicopathological features, factors, diagnosis, biomarkers, current therapy/clinical trials patients with compared non-diabetic counterparts. Thus, in-depth investigation diabetic complications on onset, development, progression discovery biomarkers would improve through early tailoring a better outcome TNBC.

Язык: Английский

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Hyperbolic multivariate feature learning in higher-order heterogeneous networks for drug-disease prediction

Artificial Intelligence in Medicine, Год журнала: 2025, Номер 162, С. 103090 - 103090

Опубликована: Фев. 19, 2025

Язык: Английский

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A nicotinamide metabolism-related gene signature for predicting immunotherapy response and prognosis in lung adenocarcinoma patients

PeerJ, Год журнала: 2025, Номер 13, С. e18991 - e18991

Опубликована: Фев. 27, 2025

Background Nicotinamide (NAM) metabolism fulfills crucial functions in tumor progression. The present study aims to establish a NAM metabolism-correlated gene (NMRG) signature assess the immunotherapy response and prognosis of lung adenocarcinoma (LUAD). Methods training set validation (the GSE31210 dataset) were collected Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO), respectively. Molecular subtypes LUAD classified by consensus clustering. Mutation landscape top 20 somatic genes was visualized maftools package. Subsequently, differential expression analysis conducted using limma package, univariate, multivariate LASSO regression analyses performed on screened construct risk model for LUAD. Next, MCP-counter, TIMER ESTIMATE algorithms utilized comprehensively immune microenvironmental profile patients different groups. efficacy chemotherapy drugs evaluated TIDE score pRRophetic A nomogram created integrating RiskScore clinical features. mRNA expressions independent prognostic NMRGs migration invasion cells measured carrying out cellular assays. Results Two (C1 C2) classified, with C1 subtype showing worse than C2. three high mutation frequency C2 TTN (45.25%), FLG (25.25%), ZNF536 (19.8%). Four ( GJB3 , CPA3 DKK1 KRT6A ) used model, which exhibited strong predictive performance. High-risk group showed low cell infiltration, score, prognosis, this drug sensitivity Cisplatin, Erlotinib, Paclitaxel, Saracatini, CGP_082996. established an accurate diagnostic all high- expressed cells, silencing inhibited cells. Conclusion novel NMRG developed, contributing evaluation personalized treatment patients.

Язык: Английский

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Niacin Ester Derivative of Brefeldin A as a Potential Dual-Target Arf1/BMX Inhibitor for Bladder Cancer

Journal of Natural Products, Год журнала: 2025, Номер unknown

Опубликована: Март 14, 2025

Bladder cancer is a common malignancy known for its high recurrence rate and poor survival rate. New strategies are urgently needed to reduce improve prognosis. Arf1 BMX potential targets associated with the prognosis of bladder cancer. In this study, niacin ester derivatives brefeldin A were synthesized by introducing nicotinic acid moieties at 4-OH 7-OH positions. Notably, 4-monoester derivative, CHNQD-01228 (2), could significantly inhibit proliferation T24 cells (IC50 = 0.22 μM) in time-dependent manner. Furthermore, it dose-dependently inhibited cell migration colony formation, induced G1 phase arrest, triggered apoptosis. Based on molecular modeling, was evaluated exhibit binding affinity toward both proteins. Further verification conducted using cellular thermal shift assays drug responsive target stability assays. It suppressed AKT/p-AKT STAT3/p-STAT3 signaling pathways targeting cells, eliminated stem activated antitumor immunity via inhibition. vivo data further demonstrated that dual-target inhibitor exhibited efficacy against MB49 allograft tumors (TGI 51.0%) thus represents promising therapeutic strategy

Язык: Английский

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