Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Сен. 4, 2024
Язык: Английский
Molecular Oncology, Год журнала: 2025, Номер unknown
Опубликована: Фев. 18, 2025
Nasopharyngeal carcinoma (NPC) is a kind of malignant tumor with high metastasis. Circular RNAs (circRNAs) are involved in progression, but their functions and mechanisms not well understood. Vasculogenic mimicry (VM) has been discovered as an alternative way to supply nutrition accelerate including NPC. We previously found that circCCNB1 (derived from cyclin B1) could inhibit the migration invasion NPC cells by binding nuclear factor 90 (NF90), however, whether additional biological still unclear. In this study, effects NF90 on generation miR‐15b‐5p miR‐7‐1‐3p were detected using qRT‐PCR, western blotting, RNA pulldown, ribonucleoprotein immunoprecipitation truncated experiments. VM formation assays used assess functions. promoted processing through competitive NF90, thereby inhibiting expression calumenin (CALU), kinesin family member 1B (KIF1B), polymerase III subunit G (POLR3G), ultimately decreasing cells. This study only reveals new function NPC, also provides insights for targeting angiogenesis therapy.
Язык: Английский
Процитировано
1
Journal of Experimental & Clinical Cancer Research, Год журнала: 2024, Номер 43(1)
Опубликована: Июнь 28, 2024
This study aimed to develop a novel six-gene expression biomarker panel enhance the early detection and risk stratification of peritoneal recurrence micrometastasis in locally advanced gastric cancer (LAGC).
Язык: Английский
Процитировано
5
Non-coding RNA Research, Год журнала: 2023, Номер 9(1), С. 236 - 252
Опубликована: Дек. 15, 2023
Gastrointestinal cancers are a huge worldwide health concern, which includes wide variety of digestive tract cancers. Circular RNAs (circRNAs), kind non-coding RNA (ncRNAs), family single-stranded, covalently closed that have become recognized as crucial gene expression regulators, having an impact on several cellular functions in cancer biology. The gut microbiome, consists different bacteria, actively contributes to the regulation host immunity, inflammation, and metabolism. CircRNAs microbiome interact significantly greatly affect growth GI cancer. Several studies focus complex circRNAs microbiota cancers, including esophageal cancer, colorectal gastric hepatocellular pancreatic It also emphasizes how changed circRNA profiles pathways connected malignancy well hallmarks gastrointestinal Furthermore, been recommended biological markers for therapeutic targets diagnostic prognostic purposes. Targeting treatment is being continued study. Despite significant initiatives, connection between emergence remains poorly understood. In this study, we will go over most recent emphasize key roles progression options. order create effective therapies plan future therapy, it important comprehend mechanisms microbiota.
Язык: Английский
Процитировано
11
Advanced Science, Год журнала: 2024, Номер 11(47)
Опубликована: Ноя. 18, 2024
Abstract The study presents a transcriptomics‐based liquid biopsy approach for early recurrence detection in locally advanced gastric cancer (LAGC). Four mRNA biomarkers (AGTR1, DNER, EPHA7, and SUSD5) linked to are identified through transcriptomic data analysis. A Risk Stratification Assessment (RSA) model combining these with clinical features showed superior predictive accuracy postoperative recurrence, AUCs of 0.919 0.935 surgical validation cohorts, respectively. Functional studies using human cell lines AGS HGC‐27 demonstrated that silencing the panel genes impaired migration, invasion, proliferation. In vivo experiments further reduced tumor growth, metastasis, lymphangiogenesis mice, possibly mediated by cAMP signaling pathway. This non‐invasive offers significant potential enhancing enabling personalized treatment strategies, thereby improving patient outcomes management LAGC.
Язык: Английский
Процитировано
4
Biochemical Genetics, Год журнала: 2025, Номер unknown
Опубликована: Март 3, 2025
Язык: Английский
Процитировано
0
World Journal of Gastroenterology, Год журнала: 2024, Номер 30(11), С. 1497 - 1523
Опубликована: Март 21, 2024
Esophageal squamous cell carcinoma (ESCC) is a malignant epithelial tumor, characterized by differentiation, it the sixth leading cause of cancer-related deaths globally. The increased mortality rate ESCC patients predominantly due to advanced stage disease when discovered, coupled with higher risk metastasis, which an exceedingly characteristic cancer, frequently high rate. Unfortunately, there currently no specific and effective marker predict treat metastasis in ESCC. MicroRNAs (miRNAs) are class small non-coding RNA molecules, approximately 22 nucleotides length. miRNAs vital modulating gene expression serve pivotal regulatory roles occurrence, progression, prognosis cancer. Here, we have examined literature highlight intimate correlations between show that regulated or genetic epigenetic factors. This review proposes potential role for as diagnostic therapeutic biomarkers ultimate aim reducing among
Язык: Английский
Процитировано
3
International Journal of Oncology, Год журнала: 2024, Номер 64(5)
Опубликована: Март 15, 2024
Circular RNA (circRNA) was first observed in the cytoplasm of eukaryotic cells 1979, but it not characterized detail until 2012, when high‑throughput sequencing technology more advanced and available. Consequently, mechanism circRNA formation its biological function have been progressively elucidated by researchers. is abundant exhibits a certain degree organization, timing disease‑specificity. Additionally, poorly degradable, meeting characteristics an ideal clinical biomarker. In present review, recent research progress circRNAs digestive tract malignant tumors primarily discussed. This included roles, functions significance circRNA, providing references for value potential gastrointestinal cancer.
Язык: Английский
Процитировано
2
Cellular Signalling, Год журнала: 2024, Номер 124, С. 111403 - 111403
Опубликована: Сен. 8, 2024
Язык: Английский
Процитировано
1
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(18), С. 9804 - 9804
Опубликована: Сен. 11, 2024
Skeletal muscle development is spotlighted in mammals since it closely relates to animal health and economic benefits the breeding industry. Researchers have successfully unveiled many regulatory factors mechanisms involving myogenesis. However, effect of N6-methyladenosine (m6A) modification, especially demethylase its regulated genes, on remains be further explored. Here, we found that typical FTO (fat mass- obesity-associated protein) was highly enriched goats’ longissimus dorsi (LD) muscles. In addition, level m6A modification transcripts negatively by during proliferation goat skeletal satellite cells (MuSCs). Moreover, a deficiency MuSCs significantly retarded their promoted expression dystrophin-associated protein 1 (DAG1). modifications DAG1 mRNA were efficiently altered FTO. Intriguingly, results levels enrichment from FB23-2 (FTO inhibitor)-treated consistent with those knockdown, indicating regulation depended modification. Further experiments showed interfering improved at site DAG1-122, recognized Insulin-like growth factor 2 mRNA-binding (IGF2BP1) consequently stabilized transcripts. Our study suggests promotes regulating through This will extend our knowledge m6A-related mechanism animals.
Язык: Английский
Процитировано
1
Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Сен. 4, 2024
Язык: Английский
Процитировано
0