EXTRA VIRGIN OLIVE OIL EFFECT IN THE COMBINATION OF ALCOHOL AND BENZENE ON THE KIDNEY OF RATTUS NOVERGICUS DOI Open Access

Adetunji Opeyemi Adebola,

ADETUNJI OLUWASEYI ADEGOKE,

Nwobi Joseph Chigbogu

и другие.

Innovare Journal of Medical Sciences, Год журнала: 2021, Номер unknown, С. 19 - 22

Опубликована: Сен. 24, 2021

Objective: This study investigated the use of extra virgin olive oil (EVOO), which is said to possess anti-inflammatory components as an ameliorative substance for induced inflammation. Methods: Forty-eight female Wistar rats were used this study. They divided into eight (1–8) groups (n=6); Control, Ethanol, Benzene, E+B, E+O, B+O, E+B+O with administration 25% 200 mg/kg/b.w 2 ml (O) EVOO in respect tagged grouping names. Animals euthanized through cervical dislocation after last day and liver was excised part fixed formalin solution 10% histological processing other homogenized biochemical assay phosphate buffer before centrifugation. Results: Histological evidence creates understanding nephrons benzene ethanol manifest likewise mitigated ability EVOO. The relative organ weight provides information on extent damage nephrons. kidney test level significantly expressed. Conclusion: Ethanol combination cause serious damage; also, they separately induce dysfunction. shown mitigate these damages.

Язык: Английский

Selenium Nanoparticles: Potential in Cancer Gene and Drug Delivery DOI

Fiona Maiyo,

Moganavelli Singh

Nanomedicine, Год журнала: 2017, Номер 12(9), С. 1075 - 1089

Опубликована: Апрель 25, 2017

In recent decades, colloidal selenium nanoparticles have emerged as exceptional species with reported chemopreventative and therapeutic properties. This has sparked widespread interest in their use a carrier of agents results displaying synergistic effects its cargo improved anticancer activity. Functionalization remains critical step nanoparticles' development for application gene or drug delivery. this review, we highlight developments the synthesis functionalization strategies used cancer delivery systems. We also provide an update preclinical studies utilizing therapeutics.

Язык: Английский

Процитировано

216
Decoding the Role of CDCA Genes in Breast Cancer Progression: Insights From in Silico and Functional Assay DOI Creative Commons

Yongsheng Zhao,

Xiaocha Ma,

Jun Zhou

и другие.

Asia-Pacific Journal of Clinical Oncology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 17, 2025

ABSTRACT Background The cell division cycle‐associated (CDCA) genes regulate key cellular processes like cycle progression and division. This study evaluates the diagnostic clinical relevance of CDCA in breast cancer. Methodology Breast cancer normal lines were cultured analyzed for gene expression using RT‐qPCR further validated public databases. Functional assays, including proliferation, colony formation, wound healing, performed following siRNA‐mediated knockdown CDCA2 CDCA3. Mutational, CNV, methylation, survival analyses, along with miRNA regulation PPI network construction, conducted to explore role progression. Results Our findings revealed significant upregulation compared controls, all these exhibiting highest potential based on AUC values ROC analysis. Pathological stage analysis indicated that CDCA5 CDCA7 significantly varied across different stages. Mutational showed had mutation rate, missense mutations being most common. CNV amplification events several genes, particularly CDCA2, CDCA3, CDCA4, CDCA7. Promoter methylation hypomethylation cancer, which correlated negatively their expression. Survival demonstrated high CDCA5, CDCA7, CDCA8 was associated worse overall survival, highlighting prognostic significance. Furthermore, immune infiltration correlations between types, suggesting a modulation. identified specific miRNAs targeting showing as biomarkers. Lastly, CDCA3 cells reduced migration, indicating critical roles tumor growth metastasis. Conclusion highlights promising biomarkers Their correlates poor impairs growth, emphasizing therapeutic targets. These suggest could be integrated into practice improved management. Clinical trial number Not applicable.

Язык: Английский

Процитировано

0
TissueCypher™: A systems biology approach to anatomic pathology DOI Creative Commons

Jeffrey W. Prichard,

Jon M. Davison,

Bruce B. Campbell

и другие.

Journal of Pathology Informatics, Год журнала: 2015, Номер 6(1), С. 48 - 48

Опубликована: Янв. 1, 2015

Current histologic methods for diagnosis are limited by intra- and inter-observer variability. Immunohistochemistry (IHC) frequently used to assess biomarkers aid diagnoses, however, IHC staining is variable nonlinear the manual interpretation subjective. Furthermore, assessed clinically typically of epithelial cell processes. Tumors premalignant tissues not composed only cells but interacting systems multiple types, including various stromal types that involved in cancer development. The complex network tissue system highlights need a biology approach anatomic pathology, which quantification processes combined with informatics tools produce actionable scores clinical decision-making.Here, we describe quantitative, multiplexed biomarker imaging termed TissueCypher™ applies pathology. Applications understanding Barrett's esophagus (BE) potential use as an adjunctive tool BE described.The Image Analysis Platform was 14 known diagnostic significance set biopsies nondysplastic reactive atypia (RA, n = 22) high-grade dysplasia (HGD, 17). Biomarker morphology features were extracted evaluated confirmed HGD cases versus RA.Multiple image analysis derived from biomarkers, immune morphology, showed significant differences between RA.The assessment abnormalities cellular changes lamina propria may serve adjunct conventional pathology BE.

Язык: Английский

Процитировано

31
Functional restoration of lysosomes and mitochondria through modulation of AKT activity ameliorates senescence DOI Creative Commons

Myeong Uk Kuk,

Haneur Lee,

Eun Seon Song

и другие.

Experimental Gerontology, Год журнала: 2023, Номер 173, С. 112091 - 112091

Опубликована: Янв. 16, 2023

Senescence is a phenomenon defined by alterations in cellular organelles and the primary cause of aging aging-related diseases. Recent studies have shown that oncogene-induced senescence driven activation serine/threonine protein kinases (AKT1, AKT2 AKT3). In this study, we evaluated twelve AKT inhibitors revealed GDC0068 as potential agent to ameliorate senescence. Senescence-ameliorating effect was evident from finding yielded lysosomal functional recovery observed reduction mass induction autophagic flux. Furthermore, GDC0068-mediated restoration function activated removal dysfunctional mitochondria, resulting mitochondrial function. Together, our findings unique mechanism which recovered lysosomes mitochondria through modulation activity.

Язык: Английский

Процитировано

9
Chemomodulatory Effect ofTrachyspermum ammion Murine Skin and Forestomach Papillomagenesis DOI

Bimala Singh,

R.K. Kale

Nutrition and Cancer, Год журнала: 2009, Номер 62(1), С. 74 - 84

Опубликована: Дек. 30, 2009

Trachyspermum ammi seed consumed worldwide as a spice ingredient is much valued for its medicinal properties. However, it has not been investigated cancer chemopreventive efficacy. Herein, the effect of different doses (2%, 4%, and 6%) test diets seeds were examined on DMBA-induced skin B(a)P-induced forestomach papillomagenesis, inducibility drug metabolizing phase I II enzymes, antioxidant enzymes(catalase, superoxide dismutase, glutathione peroxidase, glyoxalase I), reduced content, peroxidative damage. Results exhibited significant reduction in well tumor multiplicity with respect to all diet compared control group. Biochemical assays revealed increase activities enzymes especially 6% diet. A concomitant observed treated groups. The content was significantly elevated, whereas damage along lactate dehydrogenase activity three These findings indicative potential against carcinogenesis.

Язык: Английский

Процитировано

11
Contribution of surgery in management of T4b head and neck cancers: A retrospective review DOI Creative Commons
Abdul Hannan,

Fawwad Zaidi,

S. Mark Taylor

и другие.

American Journal of Otolaryngology, Год журнала: 2022, Номер 43(5), С. 103543 - 103543

Опубликована: Июль 27, 2022

Язык: Английский

Процитировано

3
The Science of Innovation : Towards Developing a Theory of Innovation DOI Open Access
Ritu Aggarwal, Avinash Sharma

Опубликована: Янв. 1, 2023

The present paper attempts to improve our understanding of the phenomenon called innovation and establish science it; from a perspective social physics modeling theories in spirit conventional domains physical sciences. Thus, aims have deeper insight into concept, properties & dynamics innovation, fostering mindset an innovative mind, developing culture innovation; thereafter move towards universal theory innovation. is expected significant impact on wide range human activities, including mutual interactions with nature beyond. This would also go long way ensuring solutions for sustainable quality life this planet as envisioned SDGs enunciated by UNO.

Язык: Английский

Процитировано

0
EXTRA VIRGIN OLIVE OIL EFFECT IN THE COMBINATION OF ALCOHOL AND BENZENE ON THE KIDNEY OF RATTUS NOVERGICUS DOI Open Access

Adetunji Opeyemi Adebola,

ADETUNJI OLUWASEYI ADEGOKE,

Nwobi Joseph Chigbogu

и другие.

Innovare Journal of Medical Sciences, Год журнала: 2021, Номер unknown, С. 19 - 22

Опубликована: Сен. 24, 2021

Objective: This study investigated the use of extra virgin olive oil (EVOO), which is said to possess anti-inflammatory components as an ameliorative substance for induced inflammation. Methods: Forty-eight female Wistar rats were used this study. They divided into eight (1–8) groups (n=6); Control, Ethanol, Benzene, E+B, E+O, B+O, E+B+O with administration 25% 200 mg/kg/b.w 2 ml (O) EVOO in respect tagged grouping names. Animals euthanized through cervical dislocation after last day and liver was excised part fixed formalin solution 10% histological processing other homogenized biochemical assay phosphate buffer before centrifugation. Results: Histological evidence creates understanding nephrons benzene ethanol manifest likewise mitigated ability EVOO. The relative organ weight provides information on extent damage nephrons. kidney test level significantly expressed. Conclusion: Ethanol combination cause serious damage; also, they separately induce dysfunction. shown mitigate these damages.

Язык: Английский

Процитировано

0