medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Апрель 27, 2024

Abstract Alterations in the gut microbiota have been linked to hypertension, with role of archaea, despite being stable constituents, remaining largely unexplored. Shotgun metagenomic analyses fecal samples were performed on 341 participants from 3 cohorts: discovery cohort (88 individuals), validation 1 (175 and 2 (78 individuals). Principal Coordinates Analysis (PCoA) based Bray-Curtis distances revealed significant alterations composition enteric archaea between control individuals hypertensive patients (P < 0.05). Hypertensive groups showed reduced abundances halophilic (Halorhabdus, Halovivax, Halorubrum_lipolyticum) methanogenic (Methanomassiliicoccus Candidatus_Methanomassiliicoccus_intestinalis). Eleven species, depleted patients, distinguished them individuals, areas under receiver operating characteristic curve 0.85, 0.79, 0.91 discovery, 1, 2, respectively. Significant correlations observed these clinical data across cohorts. Additionally, a positive correlation richness bacteria suggests close cross-kingdom synergy within microbiome. This study highlights shifts archaeal populations underscoring potential biomarkers hypertension diagnosis suggesting avenues for future therapeutic research.

Язык: Английский