Alterations in Gut Archaea Composition and Their Bacterial Interactions Linked to Hypertension DOI
Wen Yuan,

Yihang Chen,

Lirong Liang

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 27, 2024

Abstract Alterations in the gut microbiota have been linked to hypertension, with role of archaea, despite being stable constituents, remaining largely unexplored. Shotgun metagenomic analyses fecal samples were performed on 341 participants from 3 cohorts: discovery cohort (88 individuals), validation 1 (175 and 2 (78 individuals). Principal Coordinates Analysis (PCoA) based Bray-Curtis distances revealed significant alterations composition enteric archaea between control individuals hypertensive patients (P < 0.05). Hypertensive groups showed reduced abundances halophilic (Halorhabdus, Halovivax, Halorubrum_lipolyticum) methanogenic (Methanomassiliicoccus Candidatus_Methanomassiliicoccus_intestinalis). Eleven species, depleted patients, distinguished them individuals, areas under receiver operating characteristic curve 0.85, 0.79, 0.91 discovery, 1, 2, respectively. Significant correlations observed these clinical data across cohorts. Additionally, a positive correlation richness bacteria suggests close cross-kingdom synergy within microbiome. This study highlights shifts archaeal populations underscoring potential biomarkers hypertension diagnosis suggesting avenues for future therapeutic research.

Language: Английский

The Bidirectional Role Between Gut Microbiota and Sports Performance DOI

Ana Sofia Gaspar

IGI Global eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 35 - 74

Published: Feb. 28, 2025

This chapter explores the bidirectional relationship between gut microbiota and sports performance, providing a comprehensive synthesis of current scientific evidence. The influence on energy metabolism, inflammation, immune function in athletes is addressed, emphasising its potential role performance recovery. It also discussed how different intensities types exercise can impact differently, itself athletes. Various nutritional strategies are covered, such as dietary patterns use prebiotics, probiotics, symbiotics shape optimise performance. highlights importance approaches focusing athletes' being individualised tested, conclusions studies this area still mixed. concludes with call for standardised research methodologies to deepen understanding improve applications improvement.

Language: Английский

Citations

0
Integrating metagenomics and metabolomics to study the gut microbiome and host relationships in sports across different energy systems DOI Creative Commons
Viviana Aya, Daniel Pardo-Rodriguez, Laura Vega

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: May 2, 2025

Language: Английский

Citations

0
Alterations in Gut Archaea Composition and Their Bacterial Interactions Linked to Hypertension DOI
Wen Yuan,

Yihang Chen,

Lirong Liang

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 27, 2024

Abstract Alterations in the gut microbiota have been linked to hypertension, with role of archaea, despite being stable constituents, remaining largely unexplored. Shotgun metagenomic analyses fecal samples were performed on 341 participants from 3 cohorts: discovery cohort (88 individuals), validation 1 (175 and 2 (78 individuals). Principal Coordinates Analysis (PCoA) based Bray-Curtis distances revealed significant alterations composition enteric archaea between control individuals hypertensive patients (P < 0.05). Hypertensive groups showed reduced abundances halophilic (Halorhabdus, Halovivax, Halorubrum_lipolyticum) methanogenic (Methanomassiliicoccus Candidatus_Methanomassiliicoccus_intestinalis). Eleven species, depleted patients, distinguished them individuals, areas under receiver operating characteristic curve 0.85, 0.79, 0.91 discovery, 1, 2, respectively. Significant correlations observed these clinical data across cohorts. Additionally, a positive correlation richness bacteria suggests close cross-kingdom synergy within microbiome. This study highlights shifts archaeal populations underscoring potential biomarkers hypertension diagnosis suggesting avenues for future therapeutic research.

Language: Английский

Citations

0