Bioactive Materials,
Год журнала:
2021,
Номер
6(10), С. 3437 - 3448
Опубликована: Март 21, 2021
Titanium-based
scaffolds
are
widely
used
implant
materials
for
bone
defect
treatment.
However,
the
unmatched
biomechanics
and
poor
bioactivities
of
conventional
titanium-based
implants
usually
lead
to
insufficient
integration.
To
tackle
these
challenges,
it
is
critical
develop
novel
that
meet
bioadaptive
requirements
load-bearing
defects.
Herein,
inspired
by
microstructure
mechanical
properties
natural
tissue,
we
developed
a
Ti-6Al-4V
alloy
(TC4)/gelatin
methacrylate
(GelMA)
hybrid
scaffold
with
dual
bionic
features
(GMPT)
repair.
GMPT
composed
hard
3D-printed
porous
TC4
metal
(PT)
backbone,
which
mimics
cancellous
bone,
soft
GelMA
hydrogel
matrix
infiltrated
into
pores
PT
microenvironment
extracellular
matrix.
Ascribed
unique
design,
resultant
demonstrates
better
osteogenic
angiogenic
capabilities
than
PT,
as
confirmed
in
vitro
rabbit
radius
experimental
results.
Moreover,
controlling
concentration
(10%)
can
further
improve
osteogenesis
angiogenesis
GMPT.
The
fundamental
mechanisms
were
revealed
RNA-Seq
analysis,
showed
significantly
influenced
expression
osteogenesis-
angiogenesis-related
genes
via
Pi3K/Akt/mTOR
pathway.
results
this
work
indicate
our
design
represents
promising
strategy
restoration
large
Metals,
Год журнала:
2020,
Номер
10(9), С. 1139 - 1139
Опубликована: Авг. 24, 2020
β-type
titanium
(Ti)
alloys
have
attracted
a
lot
of
attention
as
novel
biomedical
materials
in
the
past
decades
due
to
their
low
elastic
moduli
and
good
biocompatibility.
This
article
provides
broad
extensive
review
Ti
terms
alloy
design,
preparation
methods,
mechanical
properties,
corrosion
behavior,
After
briefly
introducing
development
for
applications,
this
reviews
design
from
perspective
molybdenum
equivalency
(Moeq)
method
DV-Xα
molecular
orbital
method.
Based
on
these
considerable
number
are
developed.
Although
lower
compared
with
other
types
alloys,
they
still
possess
higher
than
human
bones.
Therefore,
porous
declined
modulus
been
developed
by
some
such
powder
metallurgy,
additive
manufacture
so
on.
As
reviewed,
comparable
or
even
better
biocompatibility
alloys.
Hence,
more
suitable
used
implant
materials.
However,
there
problems
biological
inertness.
such,
summarizing
findings
current
literature,
suggestions
forβ-type
bioactive
coatings
proposed
future
development.
Nanomaterials,
Год журнала:
2020,
Номер
10(6), С. 1244 - 1244
Опубликована: Июнь 26, 2020
The
propose
of
this
review
was
to
summarize
the
advances
in
multi-scale
surface
technology
titanium
implants
accelerate
osseointegration
process.
several
multi-scaled
methods
used
for
improving
wettability,
roughness,
and
bioactivity
implant
surfaces
are
reviewed.
In
addition,
macro-scale
(e.g.,
3D
printing
(3DP)
laser
texturing
(LST)),
micro-scale
grit-blasting,
acid-etching,
Sand-blasted,
Large-grit,
Acid-etching
(SLA))
nano-scale
plasma-spraying
anodization)
also
discussed,
these
known
have
favorable
properties
clinical
applications.
Functionalized
coatings
with
organic
non-organic
loadings
suggest
good
prospects
future
modern
biotechnology.
Nevertheless,
because
high
cost
low
validation,
partial
not
been
commercially
available
so
far.
A
large
number
vitro
vivo
investigations
necessary
order
obtain
in-depth
exploration
about
efficiency
functional
surfaces.
prospective
should
possess
optimum
chemistry,
bionic
characteristics,
standardized
topographies
achieve
rapid
osseointegration.
Materials Today Advances,
Год журнала:
2020,
Номер
8, С. 100097 - 100097
Опубликована: Авг. 9, 2020
Aviation
and
automobile
industries
demand
high
strength,
fatigue
resistant,
wear-resistant
materials
in
combination
with
lightweight,
especially
for
structural
applications.
On
the
other
hand,
biomedical
applications
low
modulus
stiffness
optimized
implants
better
matching
of
human
bone
combined
enhanced
strength
wear
resistance.
For
all
aforementioned
various
fields,
fabrication
parts
desired
size
shape
without
need
joining
or
welding
operations
is
while
simultaneously
reaching
improved
mechanical
properties
more
resistance
to
environmental
attack,
which
are
stringent
requirements
almost
To
achieve
these
demands,
both
material
developments,
as
well
modification
process
conditions
parameters,
essential.
Along
lines,
a
lot
research
work
focusses
on
advanced
even
disruptive
manufacturing
routes
proper
alloy
development
(e.g.
Ti,
Al,
steels,
so
on)
applying
additive
(AM)
techniques
Among
different
AM
methods,
selective
laser
melting
(SLM)
preferred
achieving
fully
dense
products
required
dimensions.
Titanium
alloys
designed
have
replaced
variety
due
their
superior
such
lightweight
good
corrosion
resistance,
achievable
through
modified
microstructures
gained
by
faster
heating
cooling
rates
realized
upon
printing.
Ti
single
(α)
dual
(α+β)
microstructure
mostly
implemented
aviation
industries,
whereas
β
exceptionally
close
that
intensively
studied
bio
dental
but
not
been
commercialized
yet.
The
Ti-based
addition
suitable
reinforcement
also
reliable
method.
In
this
article,
critical
aspects
optimization
processing
parameters
affecting
SLM
manufactured
titanium
matrix
composites
(TMCs)
will
be
presented,
future
prospects
critically
assessed.
This
expected
helpful
studies
processed
manufacturing.
Coatings,
Год журнала:
2021,
Номер
11(5), С. 487 - 487
Опубликована: Апрель 21, 2021
The
high
specific
strength,
good
corrosion
resistance,
and
great
biocompatibility
make
titanium
its
alloys
the
ideal
materials
for
biomedical
metallic
implants.
Ti-6Al-4V
alloy
is
most
employed
in
practical
applications
because
of
excellent
combination
fracture
toughness,
resistance.
However,
recent
studies
have
demonstrated
some
limits
due
to
presence
toxic
Al
V.
Consequently,
scientific
literature
has
reported
novel
β-Ti
containing
biocompatible
β-stabilizers
(such
as
Mo,
Ta,
Zr)
studying
possibility
obtain
similar
performances
alloys.
aim
this
review
highlight
resistance
passive
layers
on
β-type
Ti
human
body
environment
by
reviewing
relevant
research
contributions.
discussion
focused
all
those
factors
that
influence
performance
layer
at
surface
subjected
electrochemical
corrosion,
among
which
composition,
method
selected
grow
oxide
coating,
physicochemical
conditions
fluid
are
significant.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2020,
Номер
8
Опубликована: Ноя. 11, 2020
Depending
on
the
requirements
of
specific
applications,
implanted
materials
including
metals,
ceramics,
and
polymers
have
been
used
in
various
disciplines
medicine.
Titanium
its
alloys
as
implant
play
a
critical
role
orthopedic
dental
procedures.
However,
they
still
require
utilization
surface
modification
technologies
to
not
only
achieve
robust
osteointegration
but
also
increase
antibacterial
properties,
which
can
avoid
implant-related
infections.
This
paper
aims
provide
summary
latest
advances
techniques,
titanium
alloys,
specifically
biomedical
applications.
These
techniques
include
plasma
spray,
physical
vapor
deposition,
sol-gel,
micro-arc
oxidation,
etc.
Moreover,
microstructure
evolution
is
comprehensively
discussed,
followed
by
enhanced
mechanical
osseointegration,
clinical
outcomes.
Future
researches
should
focus
combination
multiple
methods
or
improving
structure
composition
composite
coating
further
enhance
performance.
