Nanotechnology for Multimodal Synergistic Cancer Therapy

Chemical Reviews, Год журнала: 2017, Номер 117(22), С. 13566 - 13638

Опубликована: Окт. 19, 2017

The complexity, diversity, and heterogeneity of tumors seriously undermine the therapeutic potential treatment. Therefore, current trend in clinical research has gradually shifted from a focus on monotherapy to combination therapy for enhanced treatment efficacy. More importantly, cooperative enhancement interactions between several types contribute naissance multimodal synergistic therapy, which results remarkable superadditive (namely "1 + 1 > 2") effects, stronger than any single or their theoretical combination. In this review, state-of-the-art studies concerning recent advances nanotechnology-mediated will be systematically discussed, with an emphasis construction multifunctional nanomaterials realizing bimodal trimodal as well intensive exploration underlying mechanisms explaining significant improvements outcome. Furthermore, featured applications overcoming tumor multidrug resistance, hypoxia, metastasis also discussed detail, may provide new ways efficient regression even elimination drug resistant, hypoxic solid, distant metastatic tumors. Finally, some design tips outlook future development provided, highlighting key scientific issues technical challenges requiring remediation accelerate translation.

Язык: Английский

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Aptamer-integrated DNA nanostructures for biosensing, bioimaging and cancer therapy

Chemical Society Reviews, Год журнала: 2016, Номер 45(9), С. 2583 - 2602

Опубликована: Янв. 1, 2016

We survey advances in biosensing, bioimaging and cancer therapy applications of aptamer-integrated DNA nanostructures this review.

Язык: Английский

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Recent advances in functional nanomaterials for light–triggered cancer therapy

Nano Today, Год журнала: 2018, Номер 19, С. 146 - 187

Опубликована: Март 18, 2018

Язык: Английский

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Red blood cell membrane-camouflaged nanoparticles: a novel drug delivery system for antitumor application

Acta Pharmaceutica Sinica B, Год журнала: 2019, Номер 9(4), С. 675 - 689

Опубликована: Янв. 27, 2019

Erythrocytes (red blood cells, RBCs) are the most abundant circulating cells in and have been widely used drug delivery systems (DDS) because of their features biocompatibility, biodegradability, long half-life. Accordingly, a "camouflage" comprised erythrocyte membranes renders nanoparticles as platform that combines advantages native with those nanomaterials. Following injection into animal models, coated imitate RBCs interact surroundings to achieve long-term circulation. In this review, biomimetic membrane-coated nano-cores is described regard various aspects, particular focus placed on coating mechanism, preparation methods, verification latest anti-tumor applications. Finally, further functional modifications attempts fuse surface properties multiple cell discussed, providing foundation stimulate extensive research multifunctional nano-biomimetic systems.

Язык: Английский

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Near‐Infrared Upconversion Mesoporous Cerium Oxide Hollow Biophotocatalyst for Concurrent pH‐/H₂O₂‐Responsive O₂‐Evolving Synergetic Cancer Therapy

Advanced Materials, Год журнала: 2018, Номер 30(7)

Опубликована: Янв. 8, 2018

Tumor hypoxia is typically presented in the central region of solid tumors, which mainly caused by an inadequate blood flow and oxygen supply. In conventional treatment hypoxic human not only oxygen-dependent photodynamic therapy (PDT), but also antitumor drug-based chemotherapy, considerably limited. The use direct delivering approach with PDT or chemotherapy may potentiate reactive species (ROS)-mediated cytotoxicity drug toward normal tissues. Herein, a synergetic one-for-all mesoporous cerium oxide upconversion biophotocatalyst developed to achieve intratumorally endogenous H2 O2 -responsive self-sufficiency near-infrared light controlled simultaneously for overcoming cancer. Furthermore, sufficient plays important role chemotherapeutic drug-resistant cancer hypoxia, therefore inducing tumor cell apoptosis significantly.

Язык: Английский

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Strategies for Preparing Albumin-based Nanoparticles for Multifunctional Bioimaging and Drug Delivery

Theranostics, Год журнала: 2017, Номер 7(15), С. 3667 - 3689

Опубликована: Янв. 1, 2017

Biosafety is the primary concern in clinical translation of nanomedicine. As an intrinsic ingredient human blood without immunogenicity and encouraged by its successful application Abraxane, albumin has been regarded as a promising material to produce nanoparticles for bioimaging drug delivery. The strategies synthesizing albumin-based could be generally categorized into five classes: template, nanocarrier, scaffold, stabilizer albumin-polymer conjugate. This review introduces approaches utilizing preparation thereby provides scientists with knowledge goal-driven design on

Язык: Английский

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Soft erythrocyte-based bacterial microswimmers for cargo delivery

Science Robotics, Год журнала: 2018, Номер 3(17)

Опубликована: Апрель 25, 2018

Erythrocyte-based microswimmers offer superior efficiency, stability, and deformability for active guided cargo delivery.

Язык: Английский

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The Use of Alternative Strategies for Enhanced Nanoparticle Delivery to Solid Tumors

Chemical Reviews, Год журнала: 2021, Номер 121(3), С. 1746 - 1803

Опубликована: Янв. 14, 2021

Nanomaterial (NM) delivery to solid tumors has been the focus of intense research for over a decade. Classically, scientists have tried improve NM by employing passive or active targeting strategies, making use so-called enhanced permeability and retention (EPR) effect. This phenomenon is made possible due leaky tumor vasculature through which NMs can leave bloodstream, traverse gaps in endothelial lining vessels, enter tumor. Recent studies shown that despite many efforts employ EPR effect, this process remains very poor. Furthermore, role effect called into question, where it suggested

Язык: Английский

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Cell Membrane Camouflaged Hollow Prussian Blue Nanoparticles for Synergistic Photothermal‐/Chemotherapy of Cancer

Advanced Functional Materials, Год журнала: 2017, Номер 27(11)

Опубликована: Фев. 7, 2017

Nanodrug‐based cancer therapy has been actively developed in the past decades. The main challenges faced by nanodrugs include poor drug loading capacity, rapid clearance from blood circulation, and low antitumor efficiency with high risk of recurrence. In this work, red cell (RBC) membrane camouflaged hollow mesoporous Prussian blue nanoparticles (HMPB@RBC NPs) are fabricated for combination cancer. stability, immune evading retention time HMPB@RBC NPs significantly enhanced compared those bare HMPB NPs. Doxorubicin (DOX), as a model is encapsulated within capacity up to 130% weight. addition, DOX loaded show pH‐/photoresponsive release. vivo studies demonstrate outstanding performance DOX@HMPB@RBC synergistic photothermal‐/chemotherapy

Язык: Английский

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Photosensitizer Micelles Together with IDO Inhibitor Enhance Cancer Photothermal Therapy and Immunotherapy

Advanced Science, Год журнала: 2018, Номер 5(5)

Опубликована: Фев. 26, 2018

The therapeutic outcome of photothermal therapy (PTT) remains impeded by the transparent depth light. Combining PTT with immunotherapy provides strategies to solve this problem. Regulating metabolism-related enzymes is a promising strategy stimulate immune response. Here, nanosystem (NLG919/IR780 micelles) properties conversion and regulation tryptophan metabolic pathway used suppress growth tumor margin beyond effective promote immunotherapy. It revealed that mild heat treatment promotes for upregulation shock protein (HSP), indoleamine 2,3-dioxygenase (IDO), programmed death-ligand 1 (PD-L1). NLG919/IR780 micelles can effectively inhibit activity IDO but do not affect level expression. accumulate in migrate lymph nodes lymphatic system. In vivo antitumor studies reveal following primary tumors. micelle-mediated inhibition further activation T lymphocytes, inhibiting distal tumors (abscopal effect). results demonstrate combine as well post therapy.

Язык: Английский

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