Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Сен. 17, 2024
Nanocarriers
(NCs)
play
a
crucial
role
in
delivering
theranostic
agents
to
tumors,
making
them
pivotal
focus
of
research.
However,
the
persistently
low
delivery
efficiency
engineered
NCs
has
been
significant
challenge
advancement
nanomedicine,
stirring
considerable
debate.
Transvascular
transport
is
critical
pathway
for
NC
from
vessels
yet
comprehensive
understanding
interactions
between
and
vascular
systems
remains
elusive.
In
recent
years,
efforts
have
invested
elucidating
transvascular
mechanisms
NCs,
leading
promising
advancements
tumor
theranostics.
this
context,
we
highlight
various
mechanisms,
including
enhanced
permeability
retention
effect,
cooperative
immune-driven
active
transcytosis,
cell/bacteria-mediated
delivery.
Furthermore,
explore
corresponding
strategies
aimed
at
enhancing
efficient
These
approaches
offer
intriguing
solutions
spanning
physicochemical,
biological,
pharmacological
domains
improve
therapeutic
outcomes.
Additionally,
propose
forward-looking
framework
that
relies
on
advanced
tumor/vessel
models,
high-throughput
libraries,
nano-bio
interaction
datasets,
artificial
intelligence,
which
aims
guide
design
next-generation
carriers
implementation
optimized
Modern
medicine
has
been
waging
a
war
on
cancer
for
nearly
century
with
no
tangible
end
in
sight.
Cancer
treatments
have
significantly
progressed,
but
the
need
to
increase
specificity
and
decrease
systemic
toxicities
remains.
Early
diagnosis
holds
key
improving
prognostic
outlook
patient
quality
of
life,
diagnostic
tools
are
cusp
technological
revolution.
Nanotechnology
steadily
expanded
into
reaches
chemotherapy,
radiotherapy,
diagnostics,
imaging,
demonstrating
capacity
augment
each
advance
care.
Nanomaterials
provide
an
abundance
versatility,
functionality,
applications
engineer
specifically
targeted
medicine,
accurate
early-detection
devices,
robust
imaging
modalities,
enhanced
radiotherapy
adjuvants.
This
review
provides
insights
current
clinical
pre-clinical
nanotechnological
drug
therapy,
radiation
therapy.
Pharmaceutics,
Год журнала:
2023,
Номер
15(7), С. 1796 - 1796
Опубликована: Июнь 23, 2023
Triple
negative
breast
cancer
(TNBC)
has
a
expression
of
estrogen
receptors
(ER),
progesterone
(PR),
and
human
epidermal
growth
factor
(HER2).
The
survival
rate
for
TNBC
is
generally
worse
than
other
subtypes.
treatment
made
significant
advances,
but
certain
limitations
remain.
Treatment
can
be
challenging
since
the
disease
various
molecular
A
variety
options
are
available,
such
as
chemotherapy,
immunotherapy,
radiotherapy,
surgery.
Chemotherapy
most
common
these
options.
treated
with
systemic
chemotherapy
using
drugs
anthracyclines
taxanes
in
neoadjuvant
or
adjuvant
settings.
Developing
resistance
to
anticancer
off-target
toxicity
primary
hindrances
chemotherapeutic
solutions
cancer.
It
imperative
that
researchers,
clinicians,
pharmaceutical
companies
work
together
develop
effective
TNBC.
Several
studies
have
suggested
nanotechnology
potential
solution
problem
suboptimal
treatment.
In
this
review,
we
summarized
possible
TNBC,
including
targeted
therapy,
combination
nanoparticle-based
some
future.
Moreover,
gave
general
information
about
terms
its
characteristics
aggressiveness.
ACS Nano,
Год журнала:
2022,
Номер
16(9), С. 15471 - 15483
Опубликована: Авг. 18, 2022
Both
T-cell
deprivation
and
insufficient
tumor
immunogenicity
seriously
hinder
the
efficacy
of
immune-mediated
destruction
in
melanoma.
In
this
work,
an
amphiphilic
polyethylene
glycol-poly(2-hexoxy-2-oxo-1,3,2-dioxaphospholane)
copolymer
with
a
thermally
sensitive
flowable
core
(mPEG-b-PHEP)
was
chosen
to
incorporate
IR780
dye
manganese
zinc
sulfide
nanoparticles
(ZMS)
form
polymer
micelles
(denoted
PPIR780-ZMS),
which
precisely
controlled
release
ZMS
after
being
triggered
by
near-infrared
light
(NIR).
Mn2+-mediated
chemodynamic
therapy
(CDT)
photothermal
trigger
boosted
generation
reactive
oxygen
species
(ROS),
making
PPIR780-ZMS
smart
bomblets
vivo.
It
demonstrated
that
could
maximize
immunogenic
cell
death
(ICD)
cancer,
is
characterized
abundant
damage-associated
molecular
pattern
(DAMP)
exposure.
As
result,
cytotoxic
T
cells
(CD8+)
helper
(CD4+)
expanded
infiltrated
neoplastic
foci,
further
reprogrammed
suppressive
microenvironment
(TME)
against
primary
pulmonary
metastases
safe
systemic
cytokine
expression.
addition,
cGAS-STING
signaling
pathway
activation
enhanced
antitumor
immunity
nanocomposite,
providing
practical
strategy
for
expanding
use
Mn-based
nanostructures.
Bioactive Materials,
Год журнала:
2022,
Номер
17, С. 49 - 70
Опубликована: Фев. 1, 2022
As
a
kind
of
nature-derived
bioactive
materials,
polyphenol-based
hydrogels
possess
many
unique
and
outstanding
properties
such
as
adhesion,
toughness,
self-healing
due
to
their
specific
crosslinking
structures,
which
have
been
widely
used
in
biomedical
fields
including
wound
healing,
antitumor,
treatment
motor
system
injury,
digestive
disease,
oculopathy,
bioelectronics.
In
this
review,
starting
with
the
classification
common
hydrogels,
pyramid
evolution
process
from
structures
derived
then
applications
is
elaborated,
well
efficient
reverse
design
considerations
hydrogel
systems
are
proposed.
Finally,
existing
problems
development
prospects
these
materials
discussed.
It
hoped
that
perspective
review
can
promote
further
innovation
breakthroughs
future.
ACS Nano,
Год журнала:
2023,
Номер
17(23), С. 23223 - 23261
Опубликована: Дек. 2, 2023
Stimuli-responsive
polymers
can
respond
to
internal
stimuli,
such
as
reactive
oxygen
species
(ROS),
glutathione
(GSH),
and
pH,
biological
enzymes,
external
lasers
ultrasound,
etc.,
by
changing
their
hydrophobicity/hydrophilicity,
degradability,
ionizability,
thus
have
been
widely
used
in
biomedical
applications.
Due
the
characteristics
of
tumor
microenvironment
(TME),
stimuli-responsive
that
cater
specifically
TME
extensively
prepare
smart
nanovehicles
for
targeted
delivery
therapeutic
diagnostic
agents
tissues.
Compared
conventional
drug
nanosystems,
TME-responsive
nanosystems
many
advantages,
high
sensitivity,
broad
applicability
among
different
tumors,
functional
versatility,
improved
biosafety.
In
recent
years,
a
great
deal
research
has
devoted
engineering
efficient
polymeric
significant
improvement
made
both
cancer
diagnosis
therapy.
this
review,
we
summarize
some
advances
involving
use
polymer
nanocarriers
delivery,
imaging,
therapy,
theranostics.
Various
chemical
stimuli
will
be
described
context
nanosystems.
Accordingly,
groups
responsible
responsiveness
strategies
incorporate
these
into
discussed
detail.
With
on
topic
expending
at
fast
pace,
innovative
concepts,
sequential
cascade
release,
NIR-II
multifunctional
formulations,
emerged
popular
enhanced
performance,
which
also
included
here
with
up-to-date
illustrations.
We
hope
review
offer
valuable
insights
selection
optimization
help
accelerate
future
applications
treatment.
Polymers,
Год журнала:
2022,
Номер
14(13), С. 2601 - 2601
Опубликована: Июнь 27, 2022
Passive
targeting
is
the
foremost
mechanism
by
which
nanocarriers
and
drug-bearing
macromolecules
deliver
their
payload
selectively
to
solid
tumors.
An
important
driver
of
passive
enhanced
permeability
retention
(EPR)
effect,
cornerstone
most
carrier-based
tumor-targeted
drug
delivery
efforts.
Despite
huge
number
publications
showcasing
successes
in
preclinical
animal
models,
translation
clinic
has
been
poor,
with
only
a
few
nano-based
drugs
currently
being
used
for
treatment
cancers.
Several
barriers
factors
have
adduced
low
efficiency
tumors
poor
clinical
translation,
including
characteristics
macromolecules,
vascular
physiological
barriers,
heterogeneity
tumor
blood
supply
affects
homogenous
distribution
within
tumors,
transport
penetration
depth
nanoparticles
matrix.
To
address
challenges
associated
therapeutic
efficacy
humans,
identified
that
affect
effect
macromolecular
therapeutics
nanoparticle
systems
need
be
overcome.
In
this
review,
approaches
facilitate
improved
EPR
outcomes
novel
are
discussed.
Nature Communications,
Год журнала:
2023,
Номер
14(1)
Опубликована: Авг. 25, 2023
Precise
and
efficient
image-guided
immunotherapy
holds
great
promise
for
cancer
treatment.
Here,
we
report
a
self-accelerated
nanoplatform
combining
an
aggregation-induced
emission
luminogen
(AIEgen)
hypoxia-responsive
prodrug
multifunctional
combination
immunotherapy.
The
near-infrared
AIEgen
with
methoxy
substitution
simultaneously
possesses
boosted
fluorescence
photoacoustic
(PA)
brightness
the
strong
light
absorption
ability,
as
well
amplified
type
I
II
photodynamic
therapy
(PDT)
properties
via
enhanced
intersystem
crossing
process.
By
formulating
high-performance
paclitaxel
(PTX)
into
nanoparticles,
further
camouflaging
macrophage
cell
membrane,
tumor-targeting
theranostic
agent
is
built.
integration
of
PA
imaging
helps
to
delineate
tumor
site
sensitively,
providing
accurate
guidance
light-induced
PDT
effect
could
consume
local
oxygen
lead
severer
hypoxia,
accelerating
release
PTX
drug.
As
result,
chemotherapy
induces
immunogenic
death,
which
not
only
elicit
antitumor
immunity
suppress
primary
tumor,
but
also
inhibit
growth
distant
in
4T1
tumor-bearing
female
mice.
strategy
develop
agents
rational
molecular
design
boosting
