Emerging two-dimensional monoelemental materials (Xenes) for biomedical applications

Chemical Society Reviews, Год журнала: 2019, Номер 48(11), С. 2891 - 2912

Опубликована: Янв. 1, 2019

The emergence of novel two-dimensional (2D) monoelemental materials (Xenes) has shown remarkable potential for their applications in different fields technology, as well addressing new discoveries fundamental science. Xenes (e.g., borophene, silicene, germanene, stanene, phosphorene, arsenene, antimonene, bismuthene, and tellurene) are particular interest because they the most chemically tractable synthetic exploration. Owing to excellent physical, chemical, electronic optical properties, have been regarded promising agents biosensors, bioimaging, therapeutic delivery, theranostics, several other bio-applications. In this tutorial review, we summarize general properties including classification according bulk properties. modification methods also presented. Furthermore, representative Xene nanoplatforms various biomedical highlighted. Finally, research progress, challenges, perspectives future development biomedicines discussed.

Язык: Английский

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Photothermal therapy

Journal of Controlled Release, Год журнала: 2020, Номер 325, С. 52 - 71

Опубликована: Июнь 30, 2020

Язык: Английский

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Metal Ion/Tannic Acid Assembly as a Versatile Photothermal Platform in Engineering Multimodal Nanotheranostics for Advanced Applications

ACS Nano, Год журнала: 2018, Номер 12(4), С. 3917 - 3927

Опубликована: Март 26, 2018

This study reports a family of photothermal materials, metal ion/tannic acid assemblies (MITAs). MITAs from FeIII, VIII, and RuIII afford excellent efficiency (η ≈ 40%). Sharply differing the currently existing agents, are highlighted by merits including green synthesis, facile incorporation diagnostic ions, particularly topology-independent adhesion. Owing to adhesion nature MITAs, various kinds MITA-based nanoengineerings readily available via self-adhesion onto diverse templates, enabling well suited as platform for versatile combination with other therapy approaches imaging techniques. As proof concept, polymeric/inorganic nanoparticle/nanovesicle-supported FeIII-tannic (FeIIITA) is fabricated. The effect shown be unaffected template origin type FeIIITA thickness on templates. We validate potency nanovesicle-supported (PNV@FeIIITA) tumor-specific photoactivated utilizations, NIR complete tumor elimination, (PTI), photoacoustic (PAI) in addition T1-MRI imaging. PNV@FeIIITA can simultaneously equipped functionalities, T2-MRI additionally doping MnII fluorescence encapsulating hydrophilic fluoroprobe. MITA demonstrates unparalleled superiority engineering multimodal theranostics advanced applications.

Язык: Английский

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The versatile biomedical applications of bismuth-based nanoparticles and composites: therapeutic, diagnostic, biosensing, and regenerative properties

Chemical Society Reviews, Год журнала: 2020, Номер 49(4), С. 1253 - 1321

Опубликована: Янв. 1, 2020

Bismuth-containing nanomaterials offer a new opportunity to move beyond current achievements in the fields of drug delivery, diagnosis, cancer therapy, biosensing, and tissue engineering. This review describes emerging applications perspective these nanoparticles.

Язык: Английский

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Ultrasmall Bismuth Quantum Dots: Facile Liquid-Phase Exfoliation, Characterization, and Application in High-Performance UV–Vis Photodetector

ACS Photonics, Год журнала: 2017, Номер 5(2), С. 621 - 629

Опубликована: Ноя. 20, 2017

Two-dimensional (2D) monoelemental bismuth (Bi) crystal, one of the pnictogens (group VA), has recently attracted increasing interest because its intriguing characteristics. Here, uniformly sized 2D Bi quantum dots (BiQDs) with an average diameter (thickness) 4.9 ± 1.0 nm (2.6 0.7 nm) were fabricated through a facile liquid-phase exfoliation (LPE) method, and corresponding photoresponse was evaluated using photoelectrochemical (PEC) measurements. The as-fabricated BiQDs-based photodetector not only exhibits appropriate capacity for self-driven broadband but also shows high-performance under low bias potentials ranging from UV to visible light in association long-term stability ON/OFF switching behavior. In terms these findings, it is further anticipated that resultant BiQDs possess promising potential UV–visible photodetection as well liquid optoelectronics. Our work may open new avenue delivering high-quality pnictogen QDs their bulk counterparts, thereby expanding materials.

Язык: Английский

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0D Bi nanodots/2D Bi3NbO7 nanosheets heterojunctions for efficient visible light photocatalytic degradation of antibiotics: Enhanced molecular oxygen activation and mechanism insight

Applied Catalysis B Environment and Energy, Год журнала: 2018, Номер 240, С. 39 - 49

Опубликована: Авг. 25, 2018

Язык: Английский

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Two-dimensional biomaterials: material science, biological effect and biomedical engineering applications

Chemical Society Reviews, Год журнала: 2021, Номер 50(20), С. 11381 - 11485

Опубликована: Янв. 1, 2021

To date, nanotechnology has increasingly been identified as a promising and efficient means to address number of challenges associated with public health. In the past decade, two-dimensional (2D) biomaterials, unique nanoplatform planar topology, have attracted explosive interest in various fields such biomedicine due their morphology, physicochemical properties biological effect. Motivated by progress graphene biomedicine, dozens types ultrathin 2D biomaterials found versatile bio-applications, including biosensing, biomedical imaging, delivery therapeutic agents, cancer theranostics, tissue engineering, well others. The effective utilization stems from in-depth knowledge structure-property-bioactivity-biosafety-application-performance relationships. A comprehensive summary for is still lacking. this review, we aim concentrate on state-of-the-art particular focus applications. particular, discuss design, fabrication functionalization used diverse applications based up-to-date progress. Furthermore, interactions between systems spatial-temporal scale are highlighted, which will deepen understanding underlying action mechanism aiding design improved functionalities. Finally, taking bench-to-bedside focus, conclude review proposing current crucial issues/challenges presenting future development directions advance clinical translation these emerging biomaterials.

Язык: Английский

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Low temperature photothermal therapy: Advances and perspectives

Coordination Chemistry Reviews, Год журнала: 2021, Номер 454, С. 214330 - 214330

Опубликована: Дек. 2, 2021

Язык: Английский

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BSA‐IrO₂: Catalase‐like Nanoparticles with High Photothermal Conversion Efficiency and a High X‐ray Absorption Coefficient for Anti‐inflammation and Antitumor Theranostics

Angewandte Chemie International Edition, Год журнала: 2018, Номер 57(32), С. 10309 - 10313

Опубликована: Июнь 11, 2018

Intrinsically integrating precise diagnosis, effective therapy, and self-anti-inflammatory action into a single nanoparticle is attractive for tumor treatment future clinical application, but still remains great challenge. In this study, bovine serum albumin-iridium oxide nanoparticles (BSA-IrO2 NPs) with extraordinary photothermal conversion efficiency, good photocatalytic activity, high X-ray absorption coefficient were prepared through one-step biomineralization. The allow phototherapy simultaneous photoacoustic/thermal imaging computed tomography. More importantly, BSA-IrO2 NPs can also act as catalase to protect normal cells against H2 O2 -induced reactive oxygen pressure inflammation while significantly enhancing photoacoustic microbubble-based inertial cavitation. These remarkable features may open up the exploration iridium-based nanomaterials in theranostics.

Язык: Английский

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Upconverted Metal–Organic Framework Janus Architecture for Near-Infrared and Ultrasound Co-Enhanced High Performance Tumor Therapy

ACS Nano, Год журнала: 2021, Номер 15(7), С. 12342 - 12357

Опубликована: Июнь 23, 2021

Strict conditions such as hypoxia, overexpression of glutathione (GSH), and high concentration hydrogen peroxide (H2O2) in the tumor microenvironment (TME) limit therapeutic effects reactive oxygen species (ROS) for photodynamic therapy (PDT), chemodynamic (CDT), sonodynamic (SDT). Here we fabricated a biocatalytic Janus nanocomposite (denoted UPFB) ultrasound (US) driven SDT 808 nm near-infrared (NIR) light mediated PDT by combining core-shell-shell upconversion nanoparticles (UCNPs, NaYF4:20%Yb,1%Tm@NaYF4:10%Yb@NaNdF4) ferric zirconium porphyrin metal organic framework [PCN-224(Fe)]. Our design not only substantially overcomes inefficient effect arising from inadequate Förster resonance energy transfer (FRET) process UCNPs (donor) to MOFs (acceptor) with NIR laser irradiation, but also promotes ROS generation via GSH depletion supply contributed Fe3+ ions coordinated UPFB catalase-like nanozyme. Additionally, converted Fe2+ foregoing can achieve CDT performance under acidic conditions, lysosomes. Meanwhile, linked biotin exhibits good targeting ability rapidly accumulate region, verified fluorescence imaging T2-weighted magnetic (MRI). In word, it is believed that synthesis antitumor detection heterostructures render them suitable application cancer therapeutics.

Язык: Английский

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