Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes (II)

Chemical Society Reviews, Год журнала: 2018, Номер 48(4), С. 1004 - 1076

Опубликована: Дек. 11, 2018

An updated comprehensive review to help researchers understand nanozymes better and in turn advance the field.

Язык: Английский

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Nanozymes: Classification, Catalytic Mechanisms, Activity Regulation, and Applications

Chemical Reviews, Год журнала: 2019, Номер 119(6), С. 4357 - 4412

Опубликована: Фев. 25, 2019

Because of the high catalytic activities and substrate specificity, natural enzymes have been widely used in industrial, medical, biological fields, etc. Although promising, they often suffer from intrinsic shortcomings such as cost, low operational stability, difficulties recycling. To overcome these shortcomings, researchers devoted to exploration artificial enzyme mimics for a long time. Since discovery ferromagnetic nanoparticles with horseradish peroxidase-like activity 2007, large amount studies on nanozymes constantly emerging next decade. Nanozymes are one kind nanomaterials enzymatic properties. Compared enzymes, advantages stability durability, which fields. A thorough understanding possible mechanisms will contribute development novel high-efficient nanozymes, rational regulations great significance. In this review, we systematically introduce classification, mechanism, regulation well recent research progress field biosensing, environmental protection, disease treatments, past years. We also propose current challenges their future focus. anticipate review may be significance understand properties mimicking activities.

Язык: Английский

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Nanozymes: From New Concepts, Mechanisms, and Standards to Applications

Accounts of Chemical Research, Год журнала: 2019, Номер 52(8), С. 2190 - 2200

Опубликована: Июль 5, 2019

ConspectusNanozymes are nanomaterials with intrinsic enzyme-like characteristics that have been booming over the past decade because of their capability to address limitations natural enzymes such as low stability, high cost, and difficult storage. Along rapid development ever-deepening understanding nanoscience nanotechnology, nanozymes hold promise serve direct surrogates traditional by mimicking further engineering active centers enzymes. In 2007, we reported first evidence Fe3O4 nanoparticles (NPs) peroxidase-mimicking activity, since time, hundreds found mimic catalytic activity peroxidase, oxidase, catalase, haloperoxidase, glutathione uricase, methane monooxygenase, hydrolase, superoxide dismutase. Uniquely, a broad variety simultaneously exhibit dual- or multienzyme mimetic activity. For example, NPs show pH-dependent peroxidase-like catalase-like activities; Prussian blue possess peroxidase-, catalase-, dismutase-like activity; Mn3O4 all three cellular antioxidant including dismutase, peroxidase. Taking advantage physiochemical properties nanomaterials, shown range applications from in vitro detection replacing specific living systems. With emergence new concept "nanozymology", now become an emerging field connecting nanotechnology biology.Since landmark paper on was published extensively explored mechanism, established corresponding standards quantitatively determine activities, opened up biological environmental monitoring disease diagnosis biomedicine development. Here mainly focus our progress systematic design construction functionally nanozymes, standardization nanozyme research, exploration for We also that, combining unique physicochemical can offer multifunctional platforms vivo therapy. instance, targeting antibody-conjugated ferromagnetic provide functions: target capture, magnetic separation, color detection. finally will prospect research "nanozymology". expect enzyme-mimicking attract interest both fundamental practical opportunities enzymology.

Язык: Английский

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A Mesoporous Nanoenzyme Derived from Metal–Organic Frameworks with Endogenous Oxygen Generation to Alleviate Tumor Hypoxia for Significantly Enhanced Photodynamic Therapy

Advanced Materials, Год журнала: 2019, Номер 31(27)

Опубликована: Май 16, 2019

Tumor hypoxia compromises the therapeutic efficiency of photodynamic therapy (PDT) as local oxygen concentration plays an important role in generation cytotoxic singlet (1 O2 ). Herein, a versatile mesoporous nanoenzyme (NE) derived from metal-organic frameworks (MOFs) is presented for situ endogenous to enhance PDT efficacy under bioimaging guidance. The NE constructed by first coating manganese-based MOFs with silica, followed facile annealing process ambient atmosphere. After removing silica shell and post-modifying polydopamine poly(ethylene glycol) improving biocompatibility, obtained loaded chlorin e6 (Ce6), commonly used photosensitizer PDT, high loading capacity. Upon through catalytic reaction between amount H2 , hypoxic tumor microenvironment relieved. Thus, Ce6-loaded serves -activated supplier increase significantly enhanced antitumor vitro vivo. In addition, also shows T2 -weighted magnetic resonance imaging ability its vivo tracking. This work presents interesting biomedical use MOF-derived multifunctional theranostic agent cancer therapy.

Язык: Английский

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One‐Dimensional Fe₂P Acts as a Fenton Agent in Response to NIR II Light and Ultrasound for Deep Tumor Synergetic Theranostics

Angewandte Chemie International Edition, Год журнала: 2019, Номер 58(8), С. 2407 - 2412

Опубликована: Янв. 2, 2019

Abstract The stringent reaction conditions for an effective Fenton (pH range of 3–4) hinders its application in cancer therapy. Therefore, how to improve the efficiency a tumor site has been main obstacle chemodynamic therapy (CDT). Herein, we report biocompatible one‐dimensional (1D) ferrous phosphide nanorods (FP NRs) with ultrasound (US)‐ and photothermal (PT)‐enhanced properties excellent conversion (56.6 %) NIR II window, showing synergistic therapeutic properties. Additionally, high traverse relaxivity (277.79 m −1 s ) FP NRs means they are photoacoustic imaging (PAI) magnetic resonance (MRI) agents. This is first on exploiting response metallic phosphides laser (1064 nm) CDT effect PA/MR imaging.

Язык: Английский

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Nanozymes: Activity origin, catalytic mechanism, and biological application

Coordination Chemistry Reviews, Год журнала: 2021, Номер 448, С. 214170 - 214170

Опубликована: Авг. 26, 2021

Язык: Английский

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Nanozymes-recent development and biomedical applications

Journal of Nanobiotechnology, Год журнала: 2022, Номер 20(1)

Опубликована: Фев. 22, 2022

Nanozyme is a series of nanomaterials with enzyme-mimetic activities that can proceed the catalytic reactions natural enzymes. In field biomedicine, nanozymes are capturing tremendous attention due to their high stability and low cost. Enzyme-mimetic be regulated by multiple factors, such as chemical state metal ion, pH, hydrogen peroxide (H2O2), glutathione (GSH) level, presenting great promise for biomedical applications. Over past decade, multi-functional have been developed various To promote understandings development novel multifunctional nanozymes, we herein provide comprehensive review applications in field. Nanozymes versatile enzyme-like properties briefly overviewed, mechanism application discussed future research. Finally, underlying challenges prospects frontier this review.

Язык: Английский

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Advanced bioactive nanomaterials for biomedical applications

Exploration, Год журнала: 2021, Номер 1(3)

Опубликована: Дек. 1, 2021

Bioactive materials are a kind of with unique bioactivities, which can change the cellular behaviors and elicit biological responses from living tissues. came into spotlight in late 1960s when researchers found that such as bioglass could react surrounding bone tissue for regeneration. In following decades, advances nanotechnology brought new development opportunities to bioactive nanomaterials. nanomaterials not simple miniaturization macroscopic materials. They exhibit bioactivities due their nanoscale size effect, high specific surface area, precise nanostructure, significantly influence interactions systems. Nowadays, have represented an important exciting area research. Current future applications ensure academic clinical importance. This review summaries recent field nanomaterials, evaluate factors bioactivities. Then, range potential biomedical discussed. Furthermore, limitations, challenges, also

Язык: Английский

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Catalase‐Like Nanozymes: Classification, Catalytic Mechanisms, and Their Applications

Small, Год журнала: 2022, Номер 18(37)

Опубликована: Авг. 15, 2022

The field of nanozymes has developed rapidly over the past decade. Among various oxidoreductases mimics, catalase (CAT)-like nanozyme, acting as an essential part regulation reactive oxygen species (ROS), attracted extensive research interest in recent years. However, CAT-like are not well discussed other such peroxidase (POD)-like nanozymes, etc. Compared with natural or artificial CAT enzymes, have unique properties low cost, size-dependent properties, high catalytic activity and stability, easy surface modification, etc., which make them widely used fields, especially tumor therapy disease treatment. Consequently, there is a great requirement to systematic discussion on nanozymes. In this review, some key aspects deeply summarized as: 1) Typical classified by different nanomaterials; 2) mechanisms proposed experimental theoretical studies; 3) Extensive applications regard therapy, cytoprotection sensing. Therefore, it prospected that review will contribute further design optimize their much higher efficiency than before.

Язык: Английский

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Light: A Magical Tool for Controlled Drug Delivery

Advanced Functional Materials, Год журнала: 2020, Номер 30(49)

Опубликована: Сен. 9, 2020

Light is a particularly appealing tool for on-demand drug delivery due to its noninvasive nature, ease of application and exquisite temporal spatial control. Great progress has been achieved in the development novel light-driven strategies with both breadth depth. Light-controlled platforms can be generally categorized into three groups: photochemical, photothermal, photoisomerization-mediated therapies. Various advanced materials, such as metal nanoparticles, sulfides oxides, metal-organic frameworks, carbon nanomaterials, upconversion semiconductor stimuli-responsive micelles, polymer- liposome-based nanoparticles have applied light-stimulated delivery. In view increasing interest targeted delivery, we review light-responsive systems focus on recent advances, key limitations, future directions.

Язык: Английский

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