Development of organic semiconducting materials for deep-tissue optical imaging, phototherapy and photoactivation

Chemical Society Reviews, Год журнала: 2018, Номер 48(1), С. 38 - 71

Опубликована: Ноя. 2, 2018

Recent progress in developing organic semiconducting materials (OSMs) for deep-tissue optical imaging, cancer phototherapy and biological photoactivation is summarized.

Язык: Английский

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Photosensitizers for Photodynamic Therapy

Advanced Healthcare Materials, Год журнала: 2019, Номер 8(13)

Опубликована: Май 8, 2019

Abstract As an emerging clinical modality for cancer treatment, photodynamic therapy (PDT) takes advantage of the cytotoxic activity reactive oxygen species (ROS) that are generated by light irradiating photosensitizers (PSs) in presence (O 2 ). However, further advancements including tumor selectivity and ROS generation efficiency still required. Substantial efforts devoted to design synthesize smart PSs with optimized properties achieving a desirable therapeutic efficacy. This review summarizes recent progress developing intelligent efficient PDT, ranging from single molecules delicate nanomaterials. The strategies improve through optimizing photoinduced electron transfer energy processes highlighted. Moreover, approaches combine PDT other therapeutics (e.g., chemotherapy, photothermal therapy, radiotherapy) targeted delivery cells or tissue introduced. main challenges application also discussed.

Язык: Английский

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Ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseases

Nature Communications, Год журнала: 2020, Номер 11(1)

Опубликована: Июнь 3, 2020

Oxidative stress is associated with many acute and chronic inflammatory diseases, yet limited treatment currently available clinically. The development of enzyme-mimicking nanomaterials (nanozymes) good reactive oxygen species (ROS) scavenging ability biocompatibility a promising way for the ROS-related inflammation. Herein we report simple efficient one-step ultrasmall Cu

Язык: Английский

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Molecular imaging and disease theranostics with renal-clearable optical agents

Nature Reviews Materials, Год журнала: 2021, Номер 6(12), С. 1095 - 1113

Опубликована: Июнь 23, 2021

Язык: Английский

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Molecular Targeting‐Mediated Mild‐Temperature Photothermal Therapy with a Smart Albumin‐Based Nanodrug

Small, Год журнала: 2019, Номер 15(33)

Опубликована: Июль 7, 2019

Abstract Photothermal therapy (PTT) usually requires hyperthermia >50 °C for effective tumor ablation, which inevitably induces heating damage to the surrounding normal tissues/organs. Moreover, low retention and high liver accumulation are two main obstacles that significantly limit efficacy safety of many nanomedicines. To solve these problems, a smart albumin‐based microenvironment‐responsive nanoagent is designed via self‐assembly human serum albumin (HSA), dc‐IR825 (a cyanine dye photothermal agent), gambogic acid (GA, heat shock protein 90 (HSP90) inhibitor an anticancer agent) realize molecular targeting‐mediated mild‐temperature PTT. The formed HSA/dc‐IR825/GA nanoparticles (NPs) can escape from mitochondria cytosol through mitochondrial disruption under near‐infrared (NIR) laser irradiation. GA molecules block hyperthermia‐induced overexpression HSP90, achieving reduced thermoresistance cells PTT at mild temperature (<45 °C). Furthermore, NPs show pH‐responsive charge reversal, accumulation, negligible deposition, ultimately facilitating synergistic chemotherapy. Taken together, NIR‐activated allow release drugs more precisely, ablate tumors effectively, inhibit cancer metastasis persistently, will advance development novel PTT‐based combination strategies.

Язык: Английский

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Covalent Organic Polymers Based on Fluorinated Porphyrin as Oxygen Nanoshuttles for Tumor Hypoxia Relief and Enhanced Photodynamic Therapy

Advanced Functional Materials, Год журнала: 2018, Номер 28(43)

Опубликована: Сен. 11, 2018

Abstract Effective and sustained tumor oxygenation has found practical significance in benefiting the treatment of solid tumors. In this study, fluorinated covalent organic polymers (COPs) are prepared by cross‐linking photosensitizer meso‐5, 10, 15, 20‐tetra (4‐hydroxylphenyl) porphyrin (THPP) with perfluorosebacic acid (PFSEA) poly(ethylene glycol) (PEG) via a one‐pot esterification, to enable simultaneous photodynamic treatment. Due presence PFSEA, obtained THPP pf –PEG shows efficient loading perfluoro‐15‐crown‐5‐ether (PFCE), type perfluocarbon, thereby molecular oxygen, both which would significantly enhance effect THPP. After chelating radio‐isotope, 99m Tc, PFCE‐loaded (PFCE@THPP –PEG) can be vividly visualized under single‐photon emission computed tomography (SPECT) imaging, uncovers accumulation those COPs' post intravenous injection. Owing oxygen delivery ability PFCE, is observed for mice injection PFCE@THPP –PEG, further leads greatly enhanced This study presents unique multifunctional COPs well‐defined composition, long blood circulation time, ability, showing great promises potential clinical translation

Язык: Английский

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Photosensitizer-crosslinked in-situ polymerization on catalase for tumor hypoxia modulation & enhanced photodynamic therapy

Biomaterials, Год журнала: 2018, Номер 181, С. 310 - 317

Опубликована: Авг. 4, 2018

Язык: Английский

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Magnetic Targeting of Nanotheranostics Enhances Cerenkov Radiation-Induced Photodynamic Therapy

Journal of the American Chemical Society, Год журнала: 2018, Номер 140(44), С. 14971 - 14979

Опубликована: Окт. 18, 2018

The interaction between radionuclides and nanomaterials could generate Cerenkov radiation (CR) for CR-induced photodynamic therapy (PDT) without requirement of external light excitation. However, the relatively weak CR leaves clinicians uncertain about benefits this new type PDT. Therefore, a novel strategy to amplify therapeutic effect PDT is imminently required overcome disadvantages traditional nanoparticulate such as tissue penetration limitation, dependence, low tumor accumulation photosensitizers. Herein, magnetic nanoparticles (MNPs) with 89Zr radiolabeling porphyrin molecules (TCPP) surface modification (i.e., 89Zr-MNP/TCPP) were synthesized targeting delivery. As break depth dependence PDT, these 89Zr-MNP/TCPP exhibited high under presence an field, contributing excellent together fluorescence, luminescence (CL), resonance energy transfer (CRET) multimodal imaging monitor process. present study provides major step forward in by developing advanced phototherapy tool magnetism-enhanced effective treatment tumors.

Язык: Английский

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Advances in smart mesoporous carbon nanoplatforms for photothermal–enhanced synergistic cancer therapy

Chemical Engineering Journal, Год журнала: 2022, Номер 435, С. 134886 - 134886

Опубликована: Янв. 29, 2022

Язык: Английский

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Synthesis, self-assembly and applications of functional polymers based on porphyrins

Progress in Polymer Science, Год журнала: 2019, Номер 95, С. 65 - 117

Опубликована: Май 15, 2019

Язык: Английский

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