Supramolecular Adhesive Hydrogels for Tissue Engineering Applications

Chemical Reviews, Год журнала: 2022, Номер 122(6), С. 5604 - 5640

Опубликована: Янв. 13, 2022

Tissue engineering is a promising and revolutionary strategy to treat patients who suffer the loss or failure of an organ tissue, with aim restore dysfunctional tissues enhance life expectancy. Supramolecular adhesive hydrogels are emerging as appealing materials for tissue applications owing their favorable attributes such tailorable structure, inherent flexibility, excellent biocompatibility, near-physiological environment, dynamic mechanical strength, particularly attractive self-adhesiveness. In this review, key design principles various supramolecular strategies construct comprehensively summarized. Thereafter, recent research progress regarding applications, including primarily dermal repair, muscle bone neural vascular oral corneal cardiac fetal membrane hepatic gastric systematically highlighted. Finally, scientific challenges remaining opportunities underlined show full picture hydrogels. This review expected offer comparative views critical insights inspire more advanced studies on pave way different fields even beyond applications.

Язык: Английский

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Stimuli‐Responsive Nanocomposite Hydrogels for Biomedical Applications

Advanced Functional Materials, Год журнала: 2020, Номер 31(8)

Опубликована: Ноя. 18, 2020

Abstract The complex tissue‐specific physiology that is orchestrated from the nano‐ to macroscale, in conjugation with dynamic biophysical/biochemical stimuli underlying biological processes, has inspired design of sophisticated hydrogels and nanoparticle systems exhibiting stimuli‐responsive features. Recently, nanoparticles have been combined advanced nanocomposite hybrid platforms expanding their range biomedical applications. ease flexibility attaining modular hydrogel constructs by selecting different classes nanomaterials/hydrogels, or tuning nanoparticle‐hydrogel physicochemical interactions widely expands attainable properties levels beyond those traditional platforms. This review showcases intrinsic ability react external internal/physiological scope developing intelligent application‐oriented Moreover, are overviewed context encoding cascades recapitulate signaling interplays present native biosystems. Collectively, recent breakthroughs improve potential for operating as applications benefit tailored single multi‐responsiveness.

Язык: Английский

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Insights into 2D/2D MXene Heterostructures for Improved Synergy in Structure toward Next‐Generation Supercapacitors: A Review

Advanced Functional Materials, Год журнала: 2022, Номер 32(18)

Опубликована: Фев. 3, 2022

Abstract 2D interfacial heterostructures have found an unassailable status in energy storage systems, particularly supercapacitors citing the intriguing structural and electrochemical characteristics. Exactly a decade ago, MXene, promising transition metal carbide/nitride/carbonitride was to possess excellent conductivity, hydrophilicity, laudable charge opportunities, enriched surface functionalities conducive for with inherent challenging shortcomings. To substantially improve, assembled 2D/2D MXene exhibit commendable performance backed by fact of swift increase research interest. In this review, state‐of‐the‐art progress material design are investigated. Discussion is initially on fundamentals including synthesis governing properties. Particularly, different preparation electrostatic assembly, situ growth, hydrothermal treatment, objective specific strategies its implications elaborated. Especially, interface science, electrode–electrolyte interaction ion/electron dynamics synergistic enhancement MXene/rGO, MXene/LDH, MXene/metal sulfides timely investigations other architectures provided compatibility from solid‐state microsupercapacitors commerciality. conclude, well‐comprehended outlook, key challenges, prospective guidelines stretching fundamental mechanism electrolyte optimizations presented encourage advanced future generation supercapacitors.

Язык: Английский

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Living Bacterial Hydrogels for Accelerated Infected Wound Healing

Advanced Science, Год журнала: 2021, Номер 8(24)

Опубликована: Окт. 31, 2021

Abstract Damaged skin cannot prevent harmful bacteria from invading tissues, causing infected wounds and even serious tissue damage. Traditional treatments can not only kill pathogenic bacteria, but also suppress the growth of beneficial thus destroying balance damaged microbial ecosystem. Here, a living bacterial hydrogel scaffold is reported that accelerates wound healing through secreting antibacterial substances. Lactobacillus reuteri , common probiotic, encapsulated in microspheres by emulsion polymerization further immobilized network covalent cross‐linking methacrylate‐modified hyaluronic acid. Owing to light‐initiated crosslinking, dressing be generated situ at site. This protects immune system attack, prevents escaping into local environment, avoiding potential threats. Both vitro vivo experiments show it has excellent ability against anti‐inflammatory capabilities, promoting closure new regeneration. work may open up avenues for application clinical management wounds.

Язык: Английский

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Covalently Crosslinked Hydrogels via Step‐Growth Reactions: Crosslinking Chemistries, Polymers, and Clinical Impact

Advanced Materials, Год журнала: 2021, Номер 33(25)

Опубликована: Май 14, 2021

Abstract Hydrogels are an important class of biomaterials with the unique property high‐water content in a crosslinked polymer network. In particular, chemically hydrogels have made great clinical impact past years because their desirable mechanical properties and tunability structural chemical properties. Various polymers step‐growth crosslinking chemistries harnessed for fabricating such covalently translational research. However, selecting appropriate intended application is time‐consuming challenging. It requires integration chemistry knowledge thoughtful reaction design. This task becomes even more challenging when other factors as biological mechanisms pathology, practical administration routes, regulatory requirements add additional constraints. this review, key features commonly used preparing translatable outlined performance systems summarized. The examples effective polymer/crosslinking combinations that yielded clinically approved hydrogel products specifically highlighted. These design parameters context process translation barriers, providing guideline rational selection to construct high potential further considered.

Язык: Английский

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Polysaccharide hydrogels: Functionalization, construction and served as scaffold for tissue engineering

Carbohydrate Polymers, Год журнала: 2021, Номер 278, С. 118952 - 118952

Опубликована: Ноя. 30, 2021

Язык: Английский

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Soft Bioelectronics Based on Nanomaterials

Chemical Reviews, Год журнала: 2021, Номер 122(5), С. 5068 - 5143

Опубликована: Дек. 28, 2021

Recent advances in nanostructured materials and unconventional device designs have transformed the bioelectronics from a rigid bulky form into soft ultrathin brought enormous advantages to bioelectronics. For example, mechanical deformability of thus its conformal contact onto curved organs such as brain, heart, skin allowed researchers measure high-quality biosignals, deliver real-time feedback treatments, lower long-term side-effects vivo. Here, we review various materials, fabrication methods, strategies for flexible stretchable electronics, especially focusing on biointegrated electronics using nanomaterials their composites. First, summarize top-down material processing bottom-up synthesis methods nanomaterials. Next, discuss state-of-the-art technologies intrinsically nanocomposites composed incorporated elastomers or hydrogels. We also briefly design Then individual components bioelectronics, biosensing, data storage, display, therapeutic stimulation, power supply devices, are introduced. Afterward, representative application examples described. A brief summary with discussion remaining challenges concludes review.

Язык: Английский

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Recent Progress in Biopolymer-Based Hydrogel Materials for Biomedical Applications

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(3), С. 1415 - 1415

Опубликована: Янв. 26, 2022

Hydrogels from biopolymers are readily synthesized, can possess various characteristics for different applications, and have been widely used in biomedicine to help with patient treatments outcomes. Polysaccharides, polypeptides, nucleic acids be produced into hydrogels, each unique purposes depending on their qualities. Examples of polypeptide hydrogels include collagen, gelatin, elastin, polysaccharide alginate, cellulose, glycosaminoglycan. Many theories formulated research which Flory-Rehner theory, Rubber Elasticity Theory, the calculation porosity pore size. All these take consideration enthalpy, entropy, other thermodynamic variables so that structure sizes formulated. fabricated a straightforward process using homogeneous mixture chemicals, intended purpose gel. Different types exist pH-sensitive gels, thermogels, electro-sensitive light-sensitive gels has its biomedical applications including structural capabilities, regenerative repair, or drug delivery. Major biopolymer-based cell delivery encapsulated skeletal muscle cells, osteochondral stem cells being delivered desired locations tissue regeneration. Some examples biomolecule insulin encompass cancer drugs controlled release. This review summarizes newly developed hydrogel materials mainly made since 2015 shown work present more avenues advanced medical applications.

Язык: Английский

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Hydrogels for underwater adhesion: adhesion mechanism, design strategies and applications

Journal of Materials Chemistry A, Год журнала: 2022, Номер 10(22), С. 11823 - 11853

Опубликована: Янв. 1, 2022

This review summarizes the adhesion mechanism and design strategies of underwater hydrogels, generalizes their application fields (adhesives, motion monitoring, marine environmental exploration coatings).

Язык: Английский

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Polyphenol-based hydrogels: Pyramid evolution from crosslinked structures to biomedical applications and the reverse design

Bioactive Materials, Год журнала: 2022, Номер 17, С. 49 - 70

Опубликована: Фев. 1, 2022

As a kind of nature-derived bioactive materials, polyphenol-based hydrogels possess many unique and outstanding properties such as adhesion, toughness, self-healing due to their specific crosslinking structures, which have been widely used in biomedical fields including wound healing, antitumor, treatment motor system injury, digestive disease, oculopathy, bioelectronics. In this review, starting with the classification common hydrogels, pyramid evolution process from structures derived then applications is elaborated, well efficient reverse design considerations hydrogel systems are proposed. Finally, existing problems development prospects these materials discussed. It hoped that perspective review can promote further innovation breakthroughs future.

Язык: Английский

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