Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 99, С. 105990 - 105990
Опубликована: Сен. 1, 2024
Язык: Английский
Polymers, Год журнала: 2022, Номер 14(5), С. 983 - 983
Опубликована: Фев. 28, 2022
Biopolymers are a leading class of functional material suitable for high-value applications and great interest to researchers professionals across various disciplines. Interdisciplinary research is important understand the basic applied aspects biopolymers address several complex problems associated with good health well-being. To reduce environmental impact dependence on fossil fuels, lot effort has gone into replacing synthetic polymers biodegradable materials, especially those derived from natural resources. In this regard, many types or have been developed meet needs ever-expanding applications. These currently used in food expanding their use pharmaceutical medical industries due unique properties. This review focuses uses industry provides future outlook biopolymer industry.
Язык: Английский
Процитировано
456
Materials Today Bio, Год журнала: 2022, Номер 18, С. 100522 - 100522
Опубликована: Дек. 21, 2022
Extracellular vesicles (EVs) are a collective term for nanoscale or microscale secreted by cells that play important biological roles. Mesenchymal stem class of with the potential self-healing and multidirectional differentiation. In recent years, numerous studies have shown EVs, especially those mesenchymal cells, can promote repair regeneration various tissues and, thus, significant in regenerative medicine. However, due to rapid clearance capacity circulatory system, EVs barely able act persistently at specific sites target tissues. Hydrogels good biocompatibility loose porous structural properties allow them serve as EV carriers, thereby prolonging retention certain areas slowing release EVs. When needed function sites, EV-loaded hydrogels stand an excellent approach. this review, we first introduce sources, roles, extraction characterization methods describe their current application status. We then review different types discuss factors influencing abilities carry summarize several strategies loading into characterizing hydrogels. Furthermore, applications tissue repair. This article concludes summary state research on outlook future directions, which hope will provide promising ideas researchers.
Язык: Английский
Процитировано
254
International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(7), С. 3665 - 3665
Опубликована: Март 27, 2022
Since the last few decades, development of smart hydrogels, which can respond to stimuli and adapt their responses based on external cues from environments, has become a thriving research frontier in biomedical engineering field. Nowadays, drug delivery systems have received great attention hydrogels be potentially used these due high stability, physicochemical properties, biocompatibility. Smart change hydrophilicity, swelling ability, physical molecules permeability, influenced by such as pH, temperature, electrical magnetic fields, light, biomolecules' concentration, thus resulting controlled release loaded drugs. Herein, this review encompasses latest investigations field stimuli-responsive drug-loaded our contribution matter.
Язык: Английский
Процитировано
215
Polymers, Год журнала: 2022, Номер 14(15), С. 3023 - 3023
Опубликована: Июль 26, 2022
Nowadays, there are still numerous challenges for well-known biomedical applications, such as tissue engineering (TE), wound healing and controlled drug delivery, which must be faced solved. Hydrogels have been proposed excellent candidates these they promising properties the mentioned including biocompatibility, biodegradability, great absorption capacity tunable mechanical properties. However, depending on material or manufacturing method, resulting hydrogel may not up to specific task it is designed, thus different approaches enhance performance requirements of application in question. The main purpose this review article was summarize most recent trends technology, going through used polymeric materials popular synthesis methods years, strategies enhancing hydrogels' properties, cross-linking manufacture composite hydrogels. In addition, secondary objective briefly discuss other novel applications hydrogels that past few years drawn a lot attention.
Язык: Английский
Процитировано
203
Regenerative Biomaterials, Год журнала: 2022, Номер 9
Опубликована: Янв. 1, 2022
Nowadays, biomaterials have evolved from the inert supports or functional substitutes to bioactive materials able trigger promote regenerative potential of tissues. The interdisciplinary progress has broadened definition 'biomaterials', and a typical new insight is concept tissue induction biomaterials. term 'regenerative biomaterials' thus contents this article are relevant yet beyond This review summarizes recent medical including metals, ceramics, hydrogels, other polymers bio-derived materials. As application aspects concerned, introduces for bone cartilage regeneration, cardiovascular repair, 3D bioprinting, wound healing cosmetology. Cell-biomaterial interactions highlighted. Since global pandemic coronavirus disease 2019, particularly mentions public health emergency. In last section, perspectives suggested: (i) creation source innovation; (ii) modification existing an effective strategy performance improvement; (iii) biomaterial degradation regeneration required be harmonious with each other; (iv) host responses can significantly influence clinical outcomes; (v) long-term outcomes should paid more attention to; (vi) noninvasive approaches monitoring
Язык: Английский
Процитировано
142
Polymers, Год журнала: 2023, Номер 15(3), С. 544 - 544
Опубликована: Янв. 20, 2023
Fish collagen garnered significant academic and commercial focus in the last decades featuring prospective applications a variety of health-related industries, including food, medicine, pharmaceutics, cosmetics. Due to its distinct advantages over mammalian-based collagen, reduced zoonosis transmission risk, absence cultural-religious limitations, cost-effectiveness manufacturing process, superior bioavailability, use derived from fish wastes (i.e., skin, scales) quickly expanded. Moreover, by-products are low cost need minimize industry waste’s environmental impact paved way for discards development collagen-based products with remarkable added value. This review summarizes recent advances valorization extraction used several applications. Issues related processing characterization were presented. an overview most relevant food industry, nutraceutical, cosmetics, tissue engineering, packaging three years was introduced. Lastly, fish-collagen market open technological challenges reliable recovery exploitation this biopolymer discussed.
Язык: Английский
Процитировано
101
Polymers for Advanced Technologies, Год журнала: 2023, Номер 35(1)
Опубликована: Окт. 9, 2023
Abstract Polysaccharides are a class of natural biopolymers that have attracted significant attention due to their unique properties, which make them attractive for use in wide range applications. These an important role our daily life, and designing biomaterials biomedical applications requires careful consideration factors such as biocompatibility, biodegradability, renewability, affordability, availability, all can be achieved with polysaccharides. This review paper focuses on the polysaccharides provides in‐depth analysis potential arabinoxylan, type hemicellulose, various fields, including drug delivery, infection control, tissue engineering, wound healing, others. Arabinoxylan, is derived from plants, most abundant hemicellulose has diverse catalyst its renewable nature. Polysaccharide‐based covers, delivery systems, food preservation, biocomposite films, making emerging excipient pharmaceutical research. highlights polysaccharide‐based science suggests continued research development will lead broader more innovative field. The significantly advance healthcare improve patient outcomes.
Язык: Английский
Процитировано
56
Macromolecules, Год журнала: 2023, Номер 56(21), С. 8377 - 8392
Опубликована: Окт. 18, 2023
In the past decade, stimuli-responsive hydrogels are increasingly studied as biomaterials for tissue engineering and regenerative medicine purposes. Smart can not only replicate physicochemical properties of extracellular matrix but also mimic dynamic processes that crucial regulation cell behavior. Dynamic changes be influenced by hydrogel itself (isotropic vs anisotropic) or guided applying localized triggers. The resulting swelling–shrinking, shape-morphing, well patterns have been shown to influence function in a spatiotemporally controlled manner. Furthermore, use bioinks 4D bioprinting is very promising they allow biofabrication complex microstructures. This perspective discusses recent cutting-edge advances current challenges field smart engineering. Additionally, emerging trends potential future directions addressed.
Язык: Английский
Процитировано
52
Small, Год журнала: 2023, Номер 19(48)
Опубликована: Авг. 2, 2023
To cater to the swift advance of flexible wearable electronics, there is growing demand for energy storage system (ESS). Aqueous zinc ion systems (AZIESSs), characterizing safety and low cost, are competitive candidates storage. Hydrogels, as quasi-solid substances, appropriate burgeoning electrolytes that enable high-performance AZIESSs. However, challenges still remain in designing suitable comprehensive hydrogel electrolyte, which provides AZIESSs with high reversibility versatility. Hence, application electrolyte-based electronics restricted. A thorough review required electrolyte design pave way This delves into engineering desirable from perspective designers. Detailed descriptions basic characteristics, Zn anode, cathode stabilization effects well their functional properties provided. Moreover, discussed, expecting accelerate strides toward lives. Finally, corresponding future development trends also presented, hope inspiring readers.
Язык: Английский
Процитировано
42
Advanced Materials, Год журнала: 2024, Номер 36(21)
Опубликована: Фев. 16, 2024
Immunotherapy represents a revolutionary paradigm in cancer management, showcasing its potential to impede tumor metastasis and recurrence. Nonetheless, challenges including limited therapeutic efficacy severe immune-related side effects are frequently encountered, especially solid tumors. Hydrogels, class of versatile materials featuring well-hydrated structures widely used biomedicine, offer promising platform for encapsulating releasing small molecule drugs, biomacromolecules, cells controlled manner. Immunomodulatory hydrogels present unique capability augmenting immune activation mitigating systemic toxicity through encapsulation multiple components localized administration. Notably, based on biopolymers have gained significant interest owing their biocompatibility, environmental friendliness, ease production. This review delves into the recent advances bio-based immunotherapy synergistic combinatorial approaches, highlighting diverse applications. It is anticipated that this will guide rational design field immunotherapy, fostering clinical translation ultimately benefiting patients.
Язык: Английский
Процитировано
21