Structure-optimized and microenvironment-inspired nanocomposite biomaterials in bone tissue engineering DOI Creative Commons

Zheng Lv,

Ying Ji,

Guoliang Wen

и другие.

Burns & Trauma, Год журнала: 2024, Номер 12

Опубликована: Янв. 1, 2024

Abstract Critical-sized bone defects represent a significant clinical challenge due to their inability undergo spontaneous regeneration, necessitating graft interventions for effective treatment. The development of tissue-engineered scaffolds and regenerative medicine has made tissue engineering highly viable treatment defects. physical biological properties nanocomposite biomaterials, which have optimized structures the ability simulate microenvironment bone, are promising application in field engineering. These biomaterials offer distinct advantages over traditional materials by facilitating cellular adhesion proliferation, maintaining excellent osteoconductivity biocompatibility, enabling precise control degradation rates, enhancing mechanical properties. Importantly, they can natural structure tissue, including specific microenvironment, is crucial promoting repair regeneration This manuscript provides comprehensive review recent research developments applications structure-optimized microenvironment-inspired focuses on these summarizing latest progress highlighting challenges future perspectives field. Through this analysis, paper aims underscore potential engineering, contributing informed design strategic planning next-generation medicine.

Язык: Английский

M2 macrophage-derived exosomes promote diabetic fracture healing by acting as an immunomodulator DOI Creative Commons
Yili Wang,

Qiushui Lin,

Hao Zhang

и другие.

Bioactive Materials, Год журнала: 2023, Номер 28, С. 273 - 283

Опубликована: Июнь 1, 2023

Diabetes mellitus is a chronically inflamed disease that predisposes to delayed fracture healing. Macrophages play key role in the process of healing by undergoing polarization into either M1 or M2 subtypes, which respectively exhibit pro-inflammatory anti-inflammatory functions. Therefore, modulation macrophage subtype beneficial for Exosomes perform an important improving osteoimmune microenvironment due their extremely low immunogenicity and high bioactivity. In this study, we extracted M2-exosomes used them intervene bone repair diabetic fractures. The results showed significantly modulate decreasing proportion macrophages, thereby accelerating We further confirmed induced conversion macrophages stimulating PI3K/AKT pathway. Our study offers fresh perspective potential therapeutic approach improve

Язык: Английский

Процитировано

94
Bioinspired Mild Photothermal Effect-Reinforced Multifunctional Fiber Scaffolds Promote Bone Regeneration DOI
Xiaodi Zhang, Qi Li, Longfei Li

и другие.

ACS Nano, Год журнала: 2023, Номер 17(7), С. 6466 - 6479

Опубликована: Март 30, 2023

Bone fractures are often companied with poor bone healing and high rates of infection. Early recruitment mesenchymal stem cells (MSCs) is critical for initiating efficient repair, mild thermal stimulation can accelerate the recovery chronic diseases. Here, a bioinspired, staged photothermal effect-reinforced multifunctional scaffold was fabricated repair. Uniaxially aligned electrospun polycaprolactone nanofibers were doped black phosphorus nanosheets (BP NSs) to endow excellent near-infrared (NIR) responsive capability. Apt19S then decorated on surface selectively recruit MSCs toward injured site. Afterward, microparticles phase change materials loaded antibacterial drugs also deposited scaffold, which could undergo solid-to-liquid transition above 39 °C, triggering release payload eliminate bacteria prevent Under NIR irradiation, photothermal-mediated up-regulation heat shock proteins accelerated biodegradation BP NSs promote osteogenic differentiation biomineralization. Overall, this strategy shows ability elimination, recruitment, regeneration promotion assistance effect in vitro vivo, emphasizes design bioinspired its potential tissue engineering.

Язык: Английский

Процитировано

85
Pearl Powder Hybrid Bioactive Scaffolds from Microfluidic 3D Printing for Bone Regeneration DOI Creative Commons
Lei Yang, Lu Fan, Xiang Lin

и другие.

Advanced Science, Год журнала: 2023, Номер 10(34)

Опубликована: Окт. 23, 2023

The development of bioactive scaffolds by mimicking bone tissue extracellular matrix is promising for regeneration. Herein, inspired the composition, a novel pearl powder (PP) hybrid fish gelatin methacrylate (GelMa) hydrogel scaffold loaded with vascular endothelial growth factor (VEGF) regeneration presented. With help microfluidic-assisted 3D printing technology, composition and structure can be accurately controlled to meet clinical requirements. combination skin GelMa PP also endowed good biocompatibility, cell adhesion, osteogenic differentiation ability. Moreover, release VEGF enables promote angiogenesis. Thus, in proposed could accelerated under synergic effect osteogenesis angiogenesis, which has been proved rat skull defect model. These features indicate that will an ideal candidate applications.

Язык: Английский

Процитировано

48
Recent Advances in 3D Printing of Smart Scaffolds for Bone Tissue Engineering and Regeneration DOI

Xun Yuan,

Wei Zhu, Zhongyuan Yang

и другие.

Advanced Materials, Год журнала: 2024, Номер 36(34)

Опубликована: Июнь 11, 2024

The repair and functional reconstruction of bone defects resulting from severe trauma, surgical resection, degenerative disease, congenital malformation pose significant clinical challenges. Bone tissue engineering (BTE) holds immense potential in treating these defects, without incurring prevalent complications associated with conventional autologous or allogeneic grafts. 3D printing technology enables control over architectural structures at multiple length scales has been extensively employed to process biomimetic scaffolds for BTE. In contrast inert grafts, next-generation smart possess a remarkable ability mimic the dynamic nature native extracellular matrix (ECM), thereby facilitating regeneration. Additionally, they can generate tailored controllable therapeutic effects, such as antibacterial antitumor properties, response exogenous and/or endogenous stimuli. This review provides comprehensive assessment progress 3D-printed BTE applications. It begins an introduction physiology, followed by overview technologies utilized scaffolds. Notable advances various stimuli-responsive strategies, efficacy, applications are discussed. Finally, highlights existing challenges development implementation scaffolds, well emerging this field.

Язык: Английский

Процитировано

48
TREM2 promotes macrophage polarization from M1 to M2 and suppresses osteoarthritis through the NF-κB/CXCL3 axis DOI Creative Commons
Chao Fang, Rui Zhong, Shuai Lu

и другие.

International Journal of Biological Sciences, Год журнала: 2024, Номер 20(6), С. 1992 - 2007

Опубликована: Янв. 1, 2024

Objective: Osteoarthritis (OA) is the most prominent chronic arthritic disease, affecting over 3 billion people globally.Synovial macrophages, as immune cells, play an essential role in cartilage damage OA.Therefore, regulating macrophages crucial for controlling pathological changes OA.Triggering receptor expressed on myeloid cells 2 (TREM2), cell surfaces, such and dendritic has suppressed inflammation regulated M2 macrophage polarization but demonstrated unknown synovial OA.This study aimed to investigate TREM2 expression downregulation OA mice macrophages.Furthermore, trend of was associated with polarization-related molecule mice.Results: We used knockout (TREM2-KO) observe that deficiency significantly exacerbated joint response mice, thereby accelerating disease progression.Separating chondrocytes from TREM2-KO co-cultivating them increased chondrocyte apoptosis inhibited proliferation.Further, also enhanced phosphatidylinositol 3-kinase(PI3K)/AKT signaling pathway activation, increasing nuclear factor kappa light chain enhancer activated B (NF-κB) C-X-C Motif Chemokine Ligand (CXCL3) expression.Furthermore, NF-κB inhibition arthritis effectively alleviating deficiency-related adverse effects chondrocytes.Notably, knocking down CXCL3 inhibits inflammatory promotes proliferation.Intravenous recombinant protein (soluble TREM2, sTREM2) injection markedly M1 improves tissue pathology OA.Conclusion: Our reveals during by NF-κB/CXCL3 axis regulation, improving state OA.

Язык: Английский

Процитировано

24
Biomaterials for diabetic bone repair: Influencing mechanisms, multi-aspect progress and future prospects DOI
Bingbing Wang, Yong Huang,

Qiang Cai

и другие.

Composites Part B Engineering, Год журнала: 2024, Номер 274, С. 111282 - 111282

Опубликована: Фев. 5, 2024

Язык: Английский

Процитировано

17
Deferoxamine-loaded gelatin methacryloyl hydrogel endue 3D-printed PGCL-hydroxyapatite scaffold with angiogenesis, anti-oxidative and immunoregulatory capacities for facilitating bone healing DOI
Yanlin Zhu, Zuosen Shi,

Yuxuan Pang

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 139509 - 139509

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

2
Regulation of T Cell Glycosylation by MXene/β‐TCP Nanocomposite for Enhanced Mandibular Bone Regeneration DOI Open Access
Fei Yu, Xing Zhao,

Shuting Zhang

и другие.

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 7, 2025

Immune-mediated bone regeneration driven by biomaterials offers a therapeutic strategy for repairing defects. Among 2D nanomaterials, Ti3C2Tx MXenes have garnered substantial attention their potential in tissue regeneration. This investigation concentrates on the role of MXene nanocomposites modulating immune microenvironment within defects to facilitate restoration. are synthetized, incorporated into beta-tricalcium phosphate ceramics (β-TCP) (T-MXene), and osteoinductive immunomodulatory effects evaluated. The T-MXene-treated T-cells marrow stromal cells (BMSCs) explored. In addition, its is assessed vivo using critical-sized mandibular defect model. underlying mechanisms which T-MXene regulates T-cell differentiation explored via whole-transcriptome RNA sequencing. scaffolds activate N-glycosylation T cells, possess anti-inflammatory antioxidant effects, thereby inducing pro-regenerative response. increased proportion IL-4+ among primary lymph nodes, ultimately promoting osteogenesis BMSCs injured mandibles. distinctive function MXene-based osteoimmunomodulation provides solid foundation further exploration application as response modulators, potentially advancing use regenerative medicine.

Язык: Английский

Процитировано

2
Microenvironment-responsive nanocarriers for targeted bone disease therapy DOI
Mengmeng Li,

Biao Yu,

Sicheng Wang

и другие.

Nano Today, Год журнала: 2023, Номер 50, С. 101838 - 101838

Опубликована: Март 29, 2023

Язык: Английский

Процитировано

41
Research advances of nanomaterials for the acceleration of fracture healing DOI Creative Commons

Mo Zhang,

Fan Xu,

Jingcheng Cao

и другие.

Bioactive Materials, Год журнала: 2023, Номер 31, С. 368 - 394

Опубликована: Авг. 26, 2023

The bone fracture cases have been increasing yearly, accompanied by the increased number of patients experiencing non-union or delayed union after their fracture. Although clinical materials facilitate healing (e.g., metallic and composite materials), they cannot fulfill requirements due to slow degradation rate, limited osteogenic activity, inadequate osseointegration ability, suboptimal mechanical properties. Since early 2000, nanomaterials successfully mimic nanoscale features bones offer unique properties, receiving extensive attention. This paper reviews achievements in treating intrinsic properties nanomaterials, for defect filling, drug delivery systems union). Furthermore, we discuss perspectives on challenges future directions developing accelerate healing.

Язык: Английский

Процитировано

40