Frontiers in Bioengineering and Biotechnology,
Год журнала:
2025,
Номер
13
Опубликована: Фев. 4, 2025
Osteoporosis
results
from
a
disruption
in
skeletal
homeostasis
caused
by
an
imbalance
between
bone
resorption
and
formation.
Conventional
treatments,
such
as
pharmaceutical
drugs
hormone
replacement
therapy,
often
yield
suboptimal
are
frequently
associated
with
side
effects.
Recently,
biomaterial-based
approaches
have
gained
attention
promising
alternatives
for
managing
osteoporosis.
This
review
summarizes
the
current
advancements
3D-printed
biomaterials
designed
osteoporosis
treatment.
The
benefits
of
compared
to
traditional
systemic
drug
therapies
discussed.
These
materials
can
be
broadly
categorized
based
on
their
functionalities,
including
promoting
osteogenesis,
reducing
inflammation,
exhibiting
antioxidant
properties,
inhibiting
osteoclast
activity.
3D
printing
has
advantages
speed,
precision,
personalization,
etc.
It
is
able
satisfy
requirements
irregular
geometry,
differentiated
composition,
multilayered
structure
articular
osteochondral
scaffolds
boundary
layer
structure.
limitations
existing
critically
analyzed
future
directions
considered.
Materials Today Bio,
Год журнала:
2025,
Номер
31, С. 101531 - 101531
Опубликована: Фев. 5, 2025
Three-dimensional
(3D)
printing
technology
has
shown
significant
promise
in
the
medical
field,
particularly
orthopedics,
prosthetics,
tissue
engineering,
and
pharmaceutical
preparations.
This
review
focuses
on
innovative
application
of
3D
addressing
challenges
osteonecrosis
femoral
head
(ONFH).
Unlike
traditional
hip
replacement
surgery,
which
is
often
suboptimal
for
younger
patients,
offers
precise
localization
necrotic
areas
ability
to
create
personalized
implants.
By
integrating
advanced
biomaterials,
this
a
promising
strategy
approach
early
hip-preserving
treatments.
Additionally,
3D-printed
bone
engineering
scaffolds
can
mimic
natural
environment,
promoting
regeneration
vascularization.
In
future,
potential
extends
combining
with
artificial
intelligence
optimizing
treatment
plans,
developing
materials
enhanced
bioactivity
compatibility,
translating
these
innovations
from
laboratory
clinical
practice.
demonstrates
how
uniquely
addresses
critical
ONFH
treatment,
including
insufficient
vascularization,
poor
mechanical
stability,
limited
long-term
success
conventional
therapies.
introducing
gradient
porous
scaffolds,
bioactive
material
coatings,
AI-assisted
design,
work
outlines
novel
strategies
improve
interventions.
These
advancements
not
only
enhance
efficacy
but
also
pave
way
findings
into
applications.
International Journal of Oral Science,
Год журнала:
2024,
Номер
16(1)
Опубликована: Окт. 31, 2024
Abstract
The
reconstruction
of
craniomaxillofacial
bone
defects
remains
clinically
challenging.
To
date,
autogenous
grafts
are
considered
the
gold
standard
but
present
critical
drawbacks.
These
shortcomings
have
driven
recent
research
on
to
focus
synthetic
with
distinct
materials
and
fabrication
techniques.
Among
various
methods,
additive
manufacturing
(AM)
has
shown
significant
clinical
potential.
AM
technologies
build
three-dimensional
(3D)
objects
personalized
geometry
customizable
from
a
computer-aided
design.
layer-by-layer
3D
biomaterial
structures
can
support
formation
by
guiding
cell
migration/proliferation,
osteogenesis,
angiogenesis.
Additionally,
these
be
engineered
degrade
concomitantly
new
tissue
formation,
making
them
ideal
as
grafts.
This
review
delves
into
key
advances
bioceramic
grafts/scaffolds
obtained
printing
for
reconstruction.
In
this
regard,
relevant
topics
such
ceramic-based
biomaterials,
graft/scaffold
characteristics
(macro/micro-features),
material
extrusion-based
printing,
step-by-step
workflow
engineer
discussed.
Importantly,
in
vitro
models
highlighted
conjunction
thorough
examination
signaling
pathways
reported
when
investigating
bioceramics
their
effect
cellular
response/behavior.
Lastly,
we
summarize
potential
translation
opportunities
regeneration.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 27, 2025
Tissue
engineering
aims
to
repair
damaged
tissues
with
physiological
functions
recovery.
Although
several
therapeutic
strategies
are
there
for
tissue
regeneration,
the
functional
recovery
of
regenerated
still
poses
significant
challenges
due
lack
concerns
innervation.
Design
rationale
multifunctional
biomaterials
both
tissue-induction
and
neural
induction
activities
shows
great
potential
regeneration.
Recently,
research
application
inorganic
attracts
increasing
attention
in
innervated
multi-tissue
such
as
central
nerves,
bone,
skin,
because
its
superior
tunable
chemical
composition,
topographical
structures,
physiochemical
properties.
More
importantly,
easily
combined
other
organic
materials,
biological
factors,
external
stimuli
enhance
their
effects.
This
review
presents
a
comprehensive
overview
recent
advancements
It
begins
introducing
classification
properties
typical
design
inorganic-based
material
composites.
Then,
progresses
regenerating
various
nerves
nerve-innervated
systematically
reviewed.
Finally,
existing
future
perspectives
proposed.
may
pave
way
direction
offers
new
strategy
regeneration
combination
Polymers for Advanced Technologies,
Год журнала:
2025,
Номер
36(4)
Опубликована: Март 28, 2025
ABSTRACT
Bone
repair
is
a
complex
biological
process
requiring
dynamic
interplay
between
cellular
mechanisms,
molecular
signaling,
and
environmental
factors.
The
intricate
stages
of
bone
healing,
including
hematoma
formation,
inflammation,
soft
callus
development,
hard
remodeling,
are
driven
by
coordinated
responses
pathways.
Proinflammatory
cytokines,
growth
factors,
the
extracellular
matrix
play
critical
roles
in
promoting
osteogenesis
angiogenesis.
Factors
such
as
age,
systemic
health,
mechanical
stability
significantly
influence
efficiency.
To
address
limitations
natural
advancements
regenerative
medicine
have
introduced
innovative
materials
like
nanocomposite
hydrogels,
which
mimic
microenvironment
enhance
function.
Semi‐interpenetrating
network
(semi‐IPN)
hydrogels
emerged
promising
tool
for
tissue
engineering.
Combining
crosslinked
non‐crosslinked
polymers,
these
offer
balance
stability,
functionality,
controlled
degradation.
Semi‐IPN
provide
structural
support,
facilitate
cell
attachment,
enable
sustained
release
bioactive
molecules.
Their
flexibility
adaptability
make
them
suitable
encapsulating
stem
cells
targeted
regeneration.
Moreover,
nonsurgical
surgical
scaffold
delivery
methods,
ranging
from
injectable
to
3D‐printed
magnetically
guided
scaffolds,
expanded
horizons
strategies,
reduced
invasiveness,
improved
patient
outcomes.
This
review
explores
dynamics
role
regeneration,
advanced
construction
strategies
semi‐IPN
repair.
By
integrating
polymer
science,
nanotechnology,
bioengineering,
represent
transformative
shift
addressing
defects,
paving
way
therapeutic
approaches
medicine.
With
ongoing
advancements,
technologies
hold
significant
potential
improve
effectiveness
accessibility
solutions.
