Expert Opinion on Drug Delivery,
Год журнала:
2023,
Номер
20(10), С. 1427 - 1441
Опубликована: Окт. 3, 2023
Oral
delivery
is
the
most
commonly
used
route
of
drug
administration
owing
to
good
patient
compliance.
However,
gastrointestinal
(GI)
tract
contains
multiple
physiological
barriers
that
limit
absorption
efficiency
conventional
passive
systems
resulting
in
a
low
concentration
reaching
diseased
sites.
Micro/nanorobots
can
convert
energy
self-propulsive
force,
providing
novel
platform
actively
overcome
GI
for
noninvasive
and
treatment.In
this
review,
we
first
describe
microenvironments
different
compartments
tract.
Afterward,
applications
micro/nanorobots
active
are
highlighted
discussed.
Finally,
summarize
discuss
challenges
future
prospects
further
clinical
applications.Micro/nanorobots
with
ability
autonomously
propel
themselves
load,
transport,
release
payloads
on
demand
ideal
carriers
oral
delivery.
Although
there
many
be
addressed,
have
great
potential
introduce
new
era
precision
therapy.
Advanced Materials,
Год журнала:
2023,
Номер
36(15)
Опубликована: Ноя. 1, 2023
Layered
oxides
have
become
the
research
focus
of
cathode
materials
for
sodium-ion
batteries
(SIBs)
due
to
low
cost,
simple
synthesis
process,
and
high
specific
capacity.
However,
poor
air
stability,
unstable
phase
structure
under
voltage,
slow
anionic
redox
kinetics
hinder
their
commercial
application.
In
recent
years,
concept
manipulating
orbital
hybridization
has
been
proposed
simultaneously
regulate
microelectronic
modify
surface
chemistry
environment
intrinsically.
this
review,
modes
between
atoms
in
3d/4d
transition
metal
(TM)
orbitals
O
2p
near
region
Fermi
energy
level
(E
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
12(30)
Опубликована: Авг. 9, 2023
Developing
efficient
integrated
diagnosis
and
treatment
agents
based
on
fuel-free
self-movement
nanomotors
remains
challenging
in
antitumor
therapy.
In
this
study,
a
covalent
organic
framework
(COF)-based
biomimetic
nanomotor
composed
of
polypyrrole
(PPy)
core,
porphyrin-COF
shell,
HCT116
cancer
cell
membrane
coating
is
reported.
Under
near-infrared
(NIR)
light
irradiation,
the
obtained
mPPy@COF-Por
can
overcome
Brownian
motion
achieves
directional
through
self-thermophoretic
force
generated
from
PPy
core.
The
enables
to
selectively
recognize
source
lines
reduces
bio-adhesion
biological
medium,
endowing
with
NIR
light-powered
good
mobility.
More
importantly,
such
multifunctional
integration
allows
COF-based
be
powerful
nanoagent
for
treatment,
high
infrared
thermal
imaging/photoacoustic
imaging/fluorescence
trimodal
imaging-guided
combined
photothermal/photodynamic
therapeutic
effect
tumor
successfully
achieved.
results
offer
considerable
promise
development
COF
imaging/therapy
modalities
biomedical
applications.
The European Physical Journal E,
Год журнала:
2025,
Номер
48(2)
Опубликована: Фев. 1, 2025
In
the
past
years,
amount
of
research
on
active
matter
has
grown
extremely
rapidly,
a
fact
that
is
reflected
in
particular
by
existence
more
than
1000
reviews
this
topic.
Moreover,
field
become
very
diverse,
ranging
from
theoretical
studies
statistical
mechanics
particles
to
applied
work
medical
applications
microrobots
and
biological
systems
artificial
swimmers.
This
makes
it
difficult
get
an
overview
over
as
whole.
Here,
we
provide
such
form
metareview
article
surveys
existing
review
articles
books
matter.
Thereby,
provides
useful
starting
point
for
finding
literature
about
specific
ACS Nano,
Год журнала:
2023,
Номер
17(17), С. 16731 - 16742
Опубликована: Авг. 31, 2023
Micro-/nanorobots
(MNRs)
are
envisioned
to
act
as
"motile-targeting"
platforms
for
biomedical
tasks
due
their
ability
propel
and
navigate
in
challenging,
hard-to-reach
biological
environments.
However,
it
remains
a
great
challenge
current
swarming
MNRs
accurately
report
regulate
therapeutic
doses
during
disease
treatment.
Here
we
present
the
development
of
multifunctional
heater-thermometer
nanorobots
(HT-NRs)
application
precise
feedback
photothermal
hyperthermia
delivery.
The
HT-NRs
designed
photothermal-responsive
photonic
nanochains
consisting
magnetic
Fe3O4
nanoparticles
arranged
periodically
one
dimension
encapsulated
temperature-responsive
hydrogel
shell.
exhibit
energetic
controllable
motions
under
rotating
field,
while
simultaneously
functioning
motile
nanoheaters
nanothermometers,
utilizing
conversion
(photo)thermal-responsive
structural
color
changes
(photothermochromism).
Consequently,
can
be
quickly
deployed
remote
target
area
(e.g.,
superficial
tumor
lesion)
using
collective
motion
selectively
eliminate
diseased
cells
specific
targeted
region
by
self-reporting
photothermochromism
visual
precisely
regulating
external
light
irradiation.
This
work
may
inspire
intelligent
theranostic
micro-/nanorobots
practical
applications
Trends in biotechnology,
Год журнала:
2023,
Номер
42(4), С. 479 - 495
Опубликована: Ноя. 13, 2023
The
eradication
of
drug-resistant
microbial
biofilms
remains
an
unresolved
global
health
challenge.
Small-scale
robotics
are
providing
innovative
therapeutic
and
diagnostic
approaches
with
high
precision
efficacy.
These
rapidly
moving
from
proof-of-concept
studies
to
translational
biomedical
applications
using
ex
vivo,
animal,
clinical
models.
Here,
we
discuss
the
fundamental
aspects
how
microrobots
target
infection
sites
disrupt
structural
functional
traits
their
antimicrobial
resistance
mechanisms.
We
emphasize
current
mechanochemical
disruption
on-site
drug
delivery
that
supported
by
in
vivo
models
preclinical
testing,
while
also
highlighting
diagnostics
potential.
translation
challenges
provide
perspectives
for
development
microrobotics
combat
biofilm
infections
biofouling
humans.
Abstract
The
progression
of
self‐powered
micro/‐nanomotors
(MNMs)
has
rapidly
evolved
over
the
past
few
decades,
showing
applications
in
various
fields
such
as
nanotechnology,
biomedical
engineering,
microfluidics,
environmental
science,
and
energy
harvesting.
Miniaturized
MNMs
transduce
chemical/biochemical
energies
into
mechanical
motion
for
navigating
through
complex
fluidic
environments
with
directional
control
via
external
forces
magnetic,
photonic,
electric
stimuli.
Among
propulsion
mechanisms,
buoyancy‐driven
have
received
noteworthy
recognition
due
to
their
simplicity,
efficiency,
versatility.
Buoyancy
force‐driven
motors
harness
principles
density
variation‐mediated
force
overcome
resistance
navigate
environments.
Restricting
one
direction
helps
movement,
making
it
more
efficient
isotropic
solutions.
changes
pH,
ionic
strength,
chemical
concentration,
solute
gradients,
or
presence
specific
molecules
can
influence
evidenced
by
earlier
reports.
This
review
aims
provide
a
fundamental
detailed
analysis
current
state‐of‐the‐art
MNMs,
aiming
inspire
further
research
innovation
this
promising
field.
Advanced Materials Interfaces,
Год журнала:
2024,
Номер
11(17)
Опубликована: Май 15, 2024
Abstract
Quantum
dots
(QDs)
are
recognized
as
the
most
promising
functional
nanotechnology,
for
which
its
discoverers
awarded
Nobel
Prize
in
2023.
Their
remarkable
tunability
of
optoelectronic
properties
has
attracted
significant
interest
from
both
researchers
and
industries,
placing
QDs
at
forefront
developing
cutting‐edge
technologies.
This
comprehensive
review
aims
to
explore
exciting
results
terms
fundamental
science,
present
forthcoming
applications.
Beyond
their
contributions
biomedicine,
energy,
environmental
quantum
sensing,
information
processing,
have
brought
important
due
integration
into
micro/nanorobotic
systems,
self‐propelled
materials
representing
state
art
research
micro
nanoscale.
These
hybrid
systems
demonstrated
noteworthy
outcomes,
unlocking
novel
possibilities
accurately
reviewed
this
article.
In
conclusion,
addresses
current
challenges,
offering
insights
facilitate
further
research,
stimulate
new
developments,
enhance
comprehension
full
potential
QDs.
Abstract
Self‐propelled
nanomotors
possess
strong
propulsion
and
penetration
abilities,
which
can
increase
the
efficiency
of
cellular
uptake
nanoparticles
enhance
their
cytotoxicity
against
tumor
cells,
opening
a
new
path
for
treating
major
diseases.
In
this
study,
concept
driving
by
alternately
stretching
contracting
temperature‐sensitive
polymer
(TS‐P)
chain
is
proposed.
The
TS‐Ps
are
successfully
linked
to
one
side
Cu
2‐x
Se@Au
(CS@Au)
form
Janus
structure,
designated
as
Se@Au‐polymer
(CS@Au‐P)
nanomotors.
Under
near‐infrared
(NIR)
light
irradiation,
Se
generate
photothermal
effects
that
change
system
temperature,
triggering
alternation
TS‐P
structure
mechanical
force
propels
motion
CS@Au‐P
nanomotor
significantly
improved
enhanced
accumulation
in
tumor.
Furthermore,
exceptional
conversion
suggests
potential
nanomaterials
therapy
(PTT).
prepared
material
exhibited
good
biocompatibility
anti‐tumor
both
vivo
vitro,
providing
research
insights
into
design
application
therapy.
