Expert Opinion on Drug Delivery,
Год журнала:
2023,
Номер
20(10), С. 1427 - 1441
Опубликована: Окт. 3, 2023
Oral
delivery
is
the
most
commonly
used
route
of
drug
administration
owing
to
good
patient
compliance.
However,
gastrointestinal
(GI)
tract
contains
multiple
physiological
barriers
that
limit
absorption
efficiency
conventional
passive
systems
resulting
in
a
low
concentration
reaching
diseased
sites.
Micro/nanorobots
can
convert
energy
self-propulsive
force,
providing
novel
platform
actively
overcome
GI
for
noninvasive
and
treatment.In
this
review,
we
first
describe
microenvironments
different
compartments
tract.
Afterward,
applications
micro/nanorobots
active
are
highlighted
discussed.
Finally,
summarize
discuss
challenges
future
prospects
further
clinical
applications.Micro/nanorobots
with
ability
autonomously
propel
themselves
load,
transport,
release
payloads
on
demand
ideal
carriers
oral
delivery.
Although
there
many
be
addressed,
have
great
potential
introduce
new
era
precision
therapy.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(33)
Опубликована: Апрель 18, 2024
Abstract
Liquid
metal
motors
are
unconventional
transformable
machines
whose
motion
control
is
important
for
microfluidics,
drug
delivery,
and
small‐scale
robots.
Without
an
external
field,
aluminum‐fueled
liquid
can
achieve
autonomous
propulsion,
but
the
random
direction
limits
their
applications.
Here,
study
reports
a
fundamental
discovery
of
directionally
reversing
such
through
rotating
magnetic
field
tuning
approach.
Systematic
experiments
reveal
that
motor
overcomes
irregular
Brownian
volume
limitation
metals
in
control.
Depending
on
its
volume,
exhibits
three
different
responses:
moving
opposite
to
magnet
smaller
volumes,
spinning
place
at
medium
sizes,
with
larger
ones.
This
phenomenon
attributed
interaction
electromagnetic
remote
inductions,
electrochemical
reactions,
fluid
dynamics.
Rapidly
changing
fields
induce
currents
Ampere's
force
motor,
restricting
locations
chemical
reactions.
Surface
tension
gradient
bubble
recoil
dominate
small
magnet.
As
practical
illustrations,
this
magnetically
controlled
displays
advantages
rapid
mixing.
Overall,
present
finding
significantly
improves
controllability
would
generate
profound
impacts
developing
future
soft
ACS Applied Bio Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 2, 2024
Between
2015
and
2017,
90%
of
Chinese
adults
were
reported
to
have
periodontitis
varying
degrees,
highlighting
the
importance
novel,
inexpensive,
affordable
treatments
for
public.
The
fact
that
more
pathogens
are
becoming
resistant
antibiotics
further
highlights
this
prevalence.
This
article
addresses
a
novel
micromotor
capable
generating
reactive
oxygen
species,
as
proven
by
Fenton-like
reaction.
Such
reactions
allow
targeting
Gram-negative
bacteria
such
Expert Opinion on Drug Delivery,
Год журнала:
2023,
Номер
20(10), С. 1427 - 1441
Опубликована: Окт. 3, 2023
Oral
delivery
is
the
most
commonly
used
route
of
drug
administration
owing
to
good
patient
compliance.
However,
gastrointestinal
(GI)
tract
contains
multiple
physiological
barriers
that
limit
absorption
efficiency
conventional
passive
systems
resulting
in
a
low
concentration
reaching
diseased
sites.
Micro/nanorobots
can
convert
energy
self-propulsive
force,
providing
novel
platform
actively
overcome
GI
for
noninvasive
and
treatment.In
this
review,
we
first
describe
microenvironments
different
compartments
tract.
Afterward,
applications
micro/nanorobots
active
are
highlighted
discussed.
Finally,
summarize
discuss
challenges
future
prospects
further
clinical
applications.Micro/nanorobots
with
ability
autonomously
propel
themselves
load,
transport,
release
payloads
on
demand
ideal
carriers
oral
delivery.
Although
there
many
be
addressed,
have
great
potential
introduce
new
era
precision
therapy.
