Advances in Colloid and Interface Science,
Год журнала:
2024,
Номер
330, С. 103207 - 103207
Опубликована: Июнь 3, 2024
To
overcome
the
challenges
of
poor
wound
diagnosis
and
limited
clinical
efficacy
current
management,
dressing
materials
with
aim
monitoring
various
biomarkers
vital
to
healing
process
such
as
temperature,
pH,
glucose
concentration,
reactive
oxygen
species
(ROS)
improving
therapeutic
outcomes
have
been
developed.
These
innovative
theranostic
dressings
are
smartly
engineered
using
stimuli-responsive
biomaterials
monitor
regulate
local
microenvironments
deliver
cargos
sites
in
a
timely
effective
manner.
This
review
provides
an
overview
recent
advances
novel
theranostics
for
therapy
well
giving
insights
into
future
treatment
wounds
via
smart
design
materials.
ACS Materials Letters,
Год журнала:
2023,
Номер
5(12), С. 3142 - 3155
Опубликована: Окт. 27, 2023
Antibacterial,
anti-inflammatory,
and
healing-promoting
treatment
of
chronically
infected
wounds
is
not
only
clinical
problems
to
be
solved
urgently
but
also
important
needs
related
people's
livelihood.
However,
multifunctional
hydrogel
dressings
with
highly
efficient
antibacterial,
wound
microenvironment
sensitive
drug
release
performance
still
remain
a
challenge.
In
this
work,
dressing
was
achieved
by
introducing
mussel-like
super
adhesion
catechol
groups
glucose/ROS-sensitive
dynamic
phenylboronester
bond
cross-linking
network,
which
endowed
the
excellent
injectable,
self-healing,
tissue
properties,
performance.
Additionally,
high-efficiency
photothermal
synergistic
antibacterial
TP@Ag
NPs
were
prepared
introduced
into
hydrogel.
The
glucose/ROS
responsive
borate
in
network
could
realize
NPs,
thereby
promoting
M2
polarization
achieve
an
anti-inflammatory
effect.
And
excess
reactive
oxygen
(ROS)
scavenged
effect
group
ROS-sensitive
Moreover,
biocompatibility
antioxidant
shown
hydrogels.
Finally,
fully
fill
adhere
irregular
through
injection
significantly
promote
diabetic
healing
vivo
sterilization,
ROS
scavenging
ability,
modulation
macrophage
reduce
inflammatory
response.
Thus,
it
illustrated
superiority
as
advanced
functional
for
healing.
ACS Nano,
Год журнала:
2024,
Номер
18(22), С. 14726 - 14741
Опубликована: Май 22, 2024
The
management
of
diabetic
wound
healing
remains
a
severe
clinical
challenge
due
to
the
complicated
microenvironments,
including
abnormal
immune
regulation,
excessive
reactive
oxygen
species
(ROS),
and
repeated
bacterial
infections.
Herein,
we
report
an
extracellular
matrix
(ECM)-mimetic
coating
derived
from
scallop
byssal
protein
(Sbp9Δ),
which
can
be
assembled
in
situ
within
30
min
under
trigger
Ca2+
driven
by
strong
coordination
interaction.
biocompatible
Sbp9Δ
genetically
programmable
LL37-fused
exhibit
outstanding
antioxidant,
antibacterial,
regulatory
properties
vitro.
Proof-of-concept
applications
demonstrate
that
reliably
promote
animal
models,
mice
rabbits,
ex
vivo
human
skins,
Staphylococcus
aureus-infected
mice.
In-depth
mechanism
investigation
indicates
improved
microenvironments
accelerated
repair,
alleviated
infection,
lessened
inflammation,
appearance
abundant
M2-type
macrophages,
removal
ROS,
promoted
angiogenesis,
re-epithelialization.
Collectively,
our
provides
situ,
convenient,
effective
approach
for
repair.
Wound
healing
is
a
complex,
variable,
and
time-dynamic
repair
process.
Wounds
can
be
classified
as
acute
wounds
or
chronic
wounds,
effective
wound
management
still
major
challenge
in
clinical
nursing
settings.
The
microenvironment
collectively
regulated
by
internal
biomolecules,
external
drugs,
sanitation.
Traditional
dressings
(powders,
bandages,
sponges,
etc.)
often
have
poor
therapeutic
effects
during
processes
because
they
cannot
respond
to
the
dynamic
changes
over
long-term.
Stimulus-responsive
biomaterials,
which
are
activated
various
factors
intrinsic
influences,
hold
great
promise
for
precise
drug
delivery
controlled
release.
Various
stimulus-responsive
hydrogels
been
developed
recent
years,
exhibiting
range
of
“smart”
properties,
such
interacting
with
wound,
sensing
conditions
environmental
changes,
responding
accordingly,
thereby
effectively
promoting
healing.
This
review
discusses
latest
advancements
used
We
introduce
design
scheme
stimulus-response
detail
based
on
local
biological/biochemical
peculiarities
(pH,
reactive
oxygen
species
glucose,
enzymes,
physical
microenvironments
(temperature,
light,
ultrasound,
electric
fields,
etc.).
Furthermore,
we
explore
several
promising
tissue-engineered
constructs
(nanofibers,
scaffolds,
microneedles,
microspheres).
Finally,
summarize
basis
active
research
challenges,
current
progress,
development
trends
field.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(19)
Опубликована: Фев. 26, 2024
Abstract
Drug‐resistant
bacterial
infection
of
cutaneous
wounds
causes
great
harm
to
the
human
body.
These
infections
are
characterized
by
a
microenvironment
with
recalcitrant
infections,
persistent
oxidative
stress,
imbalance
immune
regulation,
and
suboptimal
angiogenesis.
Treatment
strategies
available
date
incapable
handling
healing
dynamics
infected
wounds.
A
Schiff
base
borate
ester
cross‐linked
hydrogel,
based
on
phenylboronic
acid‐grafted
chitosan
(CS‐PBA),
dibenzaldehyde‐grafted
poly(ethylene
glycol),
tannic
acid
(TA),
is
fabricated
in
present
study.
Customized
acid‐modified
zinc
oxide
nanoparticles
(ZnO)
embedded
hydrogel
prior
gelation.
The
CPP@ZnO‐P‐TA
effectively
eliminates
methicillin‐resistant
Staphylococcus
aureus
(MRSA)
due
pH‐responsive
release
Zn
2+
TA.
Killing
achieved
via
membrane
damage,
adenosine
triphosphate
reduction,
leakage
intracellular
components,
hydrolysis
o
‐nitrophenyl‐β‐
d
‐galactopyranoside.
capable
scavenging
reactive
oxygen
nitrogen
species,
alleviating
stimulating
M2
polarization
macrophages.
released
TA
also
induce
neovascularization
PI3K/Akt
pathway.
improves
tissue
regeneration
vivo
inflammatory
responses,
angiogenesis,
facilitating
collagen
deposition.
findings
suggest
that
this
versatile
possesses
therapeutic
potential
for
treatment
MRSA‐infected
