Multifunctional dynamic chitosan-guar gum nanocomposite hydrogels in infection and diabetic wound healing

Carbohydrate Polymers, Год журнала: 2025, Номер unknown, С. 123316 - 123316

Опубликована: Янв. 1, 2025

Язык: Английский

---

Injectable Nanocomposite Hydrogel for Accelerating Diabetic Wound Healing Through Inflammatory Microenvironment Regulation

International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 1679 - 1696

Опубликована: Фев. 1, 2025

Background: A paramount issue in the realm of chronic wound healing among diabetic patients is pervasive inflammatory response that persistently thwarts angiogenesis, thereby precipitating protracted delays process such wounds. Employing zeolitic imidazolate framework-8 (ZIF-8) as a drug delivery platform, integrated within temperature-sensitive injectable hydrogel, presents an intriguing strategy for closure various irregular wounds, modulation responses, and promotion angiogenesis. Methods: Herein, ZIF-8 loaded with curcumin (Cur) combined methylcellulose/carboxymethyl chitosan (MCC) thermosensitive hydrogel was described. The assessment encompassed properties, pH-responsive release, antimicrobial activity, ROS scavenging capabilities MCC@ZIF-8@Cur hydrogel. series studies were conducted to explore its biocompatibility, pro-angiogenic effects, macrophage M2 polarization induction. Additionally, full-thickness skin defect model rat established investigate hydrogel's multifaceted efficacy facilitating repair, mitigating fostering Results: possess attribute being capable situ formation (gelation temperature ≥ 28 °C), establishing effective physical barrier multitude profiles. incorporation ZIF-8@Cur confers exceptional antibacterial properties capability eliminate reactive oxygen species (ROS). Moreover, continuously releases Cur Zn 2+ , inflammation, inducing macrophages, promoting This creates favorable immune microenvironment conducive regeneration, accelerating In vivo have demonstrated markedly accelerated ratio rats group compared Control ( p < 0.001). By 14th day healing, achieved remarkable 97.22%, considerably surpassing (72.98%), showcasing potential treating Conclusion: findings demonstrate successful creation exhibits capabilities. effectively suppresses modulates macrophages towards phenotype, promotes thus regeneration. These attributes collectively augur promising prospects applications Keywords: wound, microenvironment, polarization, angiogenesis

Язык: Английский

---

Skin‐Inspired and Self‐Regulated Hydrophobic Hydrogel for Diabetic Wound Therapy

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 10, 2025

Diabetic wounds are refractory and recurrent diseases that necessitate the development of multifunctional dressings. Inspired by structure function skin, we herein delicately design a novel swollen hydrophobic hydrogel (QL@MAB) composed methyl acrylate (MA) (3-acrylamidophenyl)boronic acid (AAPBA) network co-loaded with antioxidant quercetin (Q) antibiotic levofloxacin (L) for efficient diabetic wound therapy. The MA segments undergo phase separation to form dense "epidermis", ensuring prolonged drug diffusion, long-term water retention, high content. Meanwhile, AAPBA generate glucose-labile "sweat pores" via borate ester bonds polyphenol Q. Upon encountering hyperglycemic microenvironment, dilated due cleavage exposure diffusion channel, facilitating release accelerated healing. In infected rats, QL@MAB achieves rapid debridement re-epithelization while promoting angiogenesis, hair follicle regeneration, extracellular matrix remodeling. Taken together, this study not only represents multipronged dressing effective interventions but also contributes rational smart hydrogels tailored biomedical applications.

Язык: Английский

---

Copper doped carbon dots modified bacterial cellulose with enhanced antibacterial and immune regulatory functions for accelerating wound healing

Carbohydrate Polymers, Год журнала: 2024, Номер 346, С. 122656 - 122656

Опубликована: Авг. 26, 2024

Язык: Английский

---

Multi‐Enzyme Nanoparticles as Efficient Pyroptosis and Immunogenic Cell Death Inducers for Cancer Immunotherapy

Advanced Science, Год журнала: 2024, Номер 11(44)

Опубликована: Окт. 9, 2024

Abstract Immunotherapy represents a widely employed modality in clinical oncology, leveraging the activation of human immune system to target and eradicate cancer cells tumor tissues via endogenous mechanisms. However, its efficacy remains constrained by inadequate responses within “cold” microenvironment (TME). In this study, multifunctional nanoscale pyroptosis inducer with cascade enzymatic activity (IMZF), comprising superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), glutathione oxidase (GSHO x ), is dissociated acidic glutathione‐rich TME. The vigorous not only generates oxygen (O 2 ) alleviate hypoxia promote M2 M1 macrophage polarization but also yields reactive species (ROS) depletes (GSH) Functioning as an immunogenic cell death (ICD) activator inducer, IMZF synergistically triggers dendritic maturation inflammatory lymphocyte infiltration ICD‐associated pyroptosis, thereby reversing suppression TMEs. Consequently, it exerts inhibitory effects on both primary distal tumors. This platform‐based offers intelligent strategy for effectively overcoming tumors, providing promising avenue advanced immunotherapeutic interventions.

Язык: Английский

---

Tea polyphenol nano-crosslinked dynamical hyaluronic acid-based hydrogel for diabetic wound healing

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 136856 - 136856

Опубликована: Окт. 1, 2024

Язык: Английский

---

Rapid synthesis of CuTA/Cur@ZIF-8 multifunctional drug delivery system towards cancer treatment

Colloids and Surfaces A Physicochemical and Engineering Aspects, Год журнала: 2025, Номер unknown, С. 136321 - 136321

Опубликована: Фев. 1, 2025

Язык: Английский

---

Dual ROS/Glucose-Responsive Quercetin-Loaded Supramolecular Hydrogel for Diabetic Wound Healing

Biomacromolecules, Год журнала: 2025, Номер unknown

Опубликована: Фев. 5, 2025

Diabetic wound healing remains a significant challenge due to complex pathological mechanisms, including prolonged inflammation, excessive reactive oxygen species (ROS) accumulation, angiogenesis dysfunction, and increased susceptibility bacterial infection. In this study, we developed dual ROS/glucose-responsive quercetin-loaded supramolecular hydrogel (GPQ hydrogel) for treating diabetic wounds. The was fabricated by incorporating quercetin (QUE) into guanosine–phenylboronic acid (GP) network through dynamic borate ester bonds. Structural characterization revealed the formation of typical G-quadruplex structure in GPQ hydrogel. responsiveness ROS glucose enabled controlled release QUE, effectively addressing abnormal microenvironment diabetes. vitro studies demonstrated excellent antibacterial, antioxidant, anti-inflammatory, pro-angiogenic properties Furthermore, vivo study using full-thickness model streptozotocin-induced rats showed that significantly accelerated closure, enhanced re-epithelialization collagen deposition, promoted compared control GP groups. Immunofluorescence analysis confirmed superior antioxidant effects microenvironment. This presents promising multifunctional biomaterial managing

Язык: Английский

---

A spatial confinement biological heterogeneous cascade nanozyme composite hydrogel combined with nitric oxide gas therapy for enhanced treatment of psoriasis and diabetic wound

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160629 - 160629

Опубликована: Фев. 1, 2025

Язык: Английский

---

Polyphenol Microneedles for Dermatological Therapy

Macromolecular Bioscience, Год журнала: 2025, Номер unknown

Опубликована: Фев. 28, 2025

Abstract Dermatological diseases represent one of the most prevalent health concerns globally, with associated care and treatment costs having consistently increased over past decade. Current therapeutic modalities, including topical medications, oral pharmaceuticals, physical therapies, frequently face challenges such as inadequate drug absorption substantial adverse effects. Microneedles, recognized minimally invasive delivery systems, effectively penetrate cutaneous barrier to enhance permeability efficacy. Polyphenols—abundant in botanical marine sources—demonstrate diverse pharmacological properties encompassing anti‐inflammatory antioxidant activities. The integration polyphenols microneedle technology has emerged a promising strategy for dermatological conditions, demonstrating significant clinical potential. This review examines multifunctional capabilities polyphenol‐incorporated microneedles elucidates their mechanisms action managing disorders. Furthermore, it synthesizes recent progress polyphenol‐based applications various pathologies, acne vulgaris, psoriasis, atopic dermatitis. Finally, current is discussed proposed future research directions optimizing polyphenol systems therapeutics.

Язык: Английский

---