Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 13, 2025
Abstract
Theranostic
probes
that
integrate
diagnosis
and
treatment
together
are
considered
as
effective
tools
for
individual
therapy.
However,
the
separation
of
detection
components
limits
precise
assessment
therapeutic
efficacy.
Herein,
a
novel
self‐monitoring
probe
sensitively
responds
to
adenosine
triphosphate
(ATP)
was
developed
by
ultrafine
iron
oxide
nanowires
(UIONWs)
through
an
oleyl
amine‐assisted
way.
The
UIONWs,
with
diameter
1.5
nm
length
75
nm,
surface‐coordinated
amine.
UIONWs
can
be
decomposed
in
ATP‐containing
solution
expose
shielded
ions.
Consequently,
it
boost
peroxidase
(POD)
activity
activate
T
1
‐magnetic
resonance
imaging
(MRI)
signal
ATP.
In
addition,
rapidly
engulfed
into
cells
due
high
aspect
ratio.
improved
ATP
hydrogen
peroxide
(H
2
O
)
within
tumor
leads
higher
hydroxyl
radicals
(OH)
generation
inhibition.In
contrast,
normal
exhibit
lower
H
levels,
reducing
cytotoxicity
ensuring
safety.
Since
both
illumination
‐MRI
OH
ATP‐controlled,
this
work
raised
potential
way
self‐monitor
therapy
timely
feedback
on
effects.
Chemical Society Reviews,
Год журнала:
2023,
Номер
52(12), С. 3955 - 3972
Опубликована: Янв. 1, 2023
This
review
highlights
recent
advances
in
the
utilization
of
various
endogenous
and
exogenous
stimuli
to
activate
nanocarrier-based
ferroptosis
cancer
therapy
that
can
be
effective
treating
conventional
drug-resistant
tumors.
Bioactive Materials,
Год журнала:
2023,
Номер
32, С. 66 - 97
Опубликована: Сен. 29, 2023
Ferroptosis
offers
a
novel
method
for
overcoming
therapeutic
resistance
of
cancers
to
conventional
cancer
treatment
regimens.
Its
effective
use
as
therapy
requires
precisely
targeted
approach,
which
can
be
facilitated
by
using
nanoparticles
and
nanomedicine,
their
enhance
ferroptosis
is
indeed
growing
area
research.
While
few
review
papers
have
been
published
on
iron-dependent
mechanism
inducers
that
partly
covers
nanoparticles,
there
need
comprehensive
focusing
the
design
magnetic
typically
supply
iron
ions
promote
simultaneously
enable
nanomedicine.
Furthermore,
locally
induce
combinational
with
diagnostic
resonance
imaging
(MRI).
The
remotely
controllable
nanocarriers
offer
highly
localized
image-guided
Here,
recent
developments
in
magnetically
manipulable
nanomedicine
medical
are
summarized.
This
also
highlights
advantages
current
state-of-the-art
Finally,
image
guided
apoptosis-based
enables
synergistic
tumor
discussed
clinical
translations.
Coatings,
Год журнала:
2023,
Номер
14(1), С. 25 - 25
Опубликована: Дек. 25, 2023
Adsorbed
molecules
can
modulate
the
behavior
of
magnesium
(Mg)
and
Mg
alloy
in
biomedical
applications.
The
interaction
regularity
mechanism
biomolecules
(such
as
amino
acids,
dipeptides,
tripeptide)
on
a
Mg(0001)
surface,
influence
dipole
correction,
effects
alloying
elements
electronic
structure
were
investigated
this
study
using
first-principles
calculations.
Specifically,
adsorption
energy
(Eads)
functional
groups
(-NH2,
-COOH
-CN3H4),
acids
(arginine
(Arg),
glycine
(Gly),
aspartic
acid
(Asp)),
dipeptides
(arginine–glycine
(Arg-Gly),
glycine–aspartic
(Gly-Asp),
arginine–aspartic
(Arg-Asp)),
arginine–glycine–aspartic
(RGD)
tripeptide
systematically
calculated.
Dipole
correction
slightly
enhanced
between
surfaces,
but
Eads
trend
remained
unchanged.
addition
improved
Mg-based
surfaces.
This
will
be
fundamental
importance
understanding
surfaces
provide
possibilities
for
surface
modification
design
materials.
Advanced Materials,
Год журнала:
2024,
Номер
36(27)
Опубликована: Март 29, 2024
Cancer
treatment
requires
precise
tumor-specific
targeting
at
specific
sites
that
allows
for
high-resolution
diagnostic
imaging
and
long-term
patient-tailorable
cancer
therapy;
while,
minimizing
side
effects
largely
arising
from
non-targetability.
This
can
be
realized
by
harnessing
exogenous
remote
stimuli,
such
as
tissue-penetrative
ultrasound,
magnetic
field,
light,
radiation,
enable
local
activation
therapy
in
deep
tumors.
A
myriad
of
nanomedicines
efficiently
activated
when
the
energy
stimuli
transformed
into
another
type
energy.
review
discusses
control
transformation
targetable,
efficient,
therapy.
Such
ultrasonic,
magnetic,
photonic,
radiative,
radioactive
mechanical,
thermal,
chemical,
radiative
to
a
variety
modalities.
The
current
article
describes
multimodal
where
serial
cascade
or
multiple
types
occur.
includes
not
only
hyperthermia,
radiation
but
also
emerging
thermoelectric,
pyroelectric,
piezoelectric
therapies
treatment.
It
illustrates
resonance,
fluorescence,
computed
tomography,
photoluminescence,
photoacoustic
imaging-guided
therapies.
highlights
afterglow
eliminate
autofluorescence
sustained
signal
emission
after
excitation.
Abstract
Foreign
body
reaction
(FBR)
is
a
prevalent
yet
often
overlooked
pathological
phenomenon,
particularly
within
the
field
of
biomedical
implantation.
The
presence
FBR
poses
heavy
burden
on
both
medical
and
socioeconomic
systems.
This
review
seeks
to
elucidate
protein
“fingerprint”
implant
materials,
which
generated
by
physiochemical
properties
materials
themselves.
In
this
review,
activity
macrophages,
formation
foreign
giant
cells
(FBGCs),
development
fibrosis
capsules
in
context
are
introduced.
Additionally,
relationship
between
various
elucidated
detail,
as
an
overview
existing
approaches
technologies
employed
alleviate
FBR.
Finally,
significance
components
(metallic
non‐metallic
materials),
surface
CHEMISTRY
(charge
wettability),
physical
characteristics
(topography,
roughness,
stiffness)
establishing
also
well
documented.
conclusion,
aims
emphasize
importance
provides
current
perspectives
developing
with
anti‐FBR
properties.
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 26, 2025
Abstract
Native
tissues
exhibit
hierarchical
structures
of
anisotropically
arranged
extracellular
matrix
that
dynamically
regulate
stem
cells
and
tissue
function.
However,
neither
multiscale
nano‐anisotropy
nor
dynamic
anisotropy
control
have
been
reported.
In
this
study,
spherical
or
rod‐shaped
gold
small‐nanomaterials
(at
integrin
receptor‐scale;
tens
nanometers)
are
coupled
to
the
surface
magnetic
large‐nanomaterials
focal
adhesion
complex‐scale;
hundreds
nanometers),
with
both
showing
constant
areas
at
each
respective
scale.
Each
nanocomposite
is
flexibly
conjugated
substrate
material
densities,
resulting
in
dual‐scale
liganded
nano‐anisotropies.
Increasing
aspect
ratio
nanomaterials
nanometer‐scale
dominantly
promotes
recruitment,
adhesion,
mechanotransduction,
differentiation
over
nanometer‐scale.
Such
scale‐specific
effects
on
cell
regulation
temporally
regulated
vitro
vivo
by
physically
raising
lowering
nanocomposites
respectively
inhibit
stimulate
curved
surfaces
modulating
membrane
bending.
unprecedented
“dynamic
ligand
anisotropy”
can
be
independently
engineered
regarding
scales,
anisotropies,
ligands
elucidate
cell‐material
interactions
allow
for
multimodal
enhance
tissue‐regenerative
therapy.
