Stimuli-responsive ferroptosis for cancer therapy

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(12), P. 3955 - 3972

Published: Jan. 1, 2023

This review highlights recent advances in the utilization of various endogenous and exogenous stimuli to activate nanocarrier-based ferroptosis cancer therapy that can be effective treating conventional drug-resistant tumors.

Language: Английский

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Magnetic nanoparticles for ferroptosis cancer therapy with diagnostic imaging

Bioactive Materials, Journal Year: 2023, Volume and Issue: 32, P. 66 - 97

Published: Sept. 29, 2023

Ferroptosis offers a novel method for overcoming therapeutic resistance of cancers to conventional cancer treatment regimens. Its effective use as therapy requires precisely targeted approach, which can be facilitated by using nanoparticles and nanomedicine, their enhance ferroptosis is indeed growing area research. While few review papers have been published on iron-dependent mechanism inducers that partly covers nanoparticles, there need comprehensive focusing the design magnetic typically supply iron ions promote simultaneously enable nanomedicine. Furthermore, locally induce combinational with diagnostic resonance imaging (MRI). The remotely controllable nanocarriers offer highly localized image-guided Here, recent developments in magnetically manipulable nanomedicine medical are summarized. This also highlights advantages current state-of-the-art Finally, image guided apoptosis-based enables synergistic tumor discussed clinical translations.

Language: Английский

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Remote Control of Energy Transformation‐Based Cancer Imaging and Therapy

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(27)

Published: March 29, 2024

Cancer treatment requires precise tumor-specific targeting at specific sites that allows for high-resolution diagnostic imaging and long-term patient-tailorable cancer therapy; while, minimizing side effects largely arising from non-targetability. This can be realized by harnessing exogenous remote stimuli, such as tissue-penetrative ultrasound, magnetic field, light, radiation, enable local activation therapy in deep tumors. A myriad of nanomedicines efficiently activated when the energy stimuli transformed into another type energy. review discusses control transformation targetable, efficient, therapy. Such ultrasonic, magnetic, photonic, radiative, radioactive mechanical, thermal, chemical, radiative to a variety modalities. The current article describes multimodal where serial cascade or multiple types occur. includes not only hyperthermia, radiation but also emerging thermoelectric, pyroelectric, piezoelectric therapies treatment. It illustrates resonance, fluorescence, computed tomography, photoluminescence, photoacoustic imaging-guided therapies. highlights afterglow eliminate autofluorescence sustained signal emission after excitation.

Language: Английский

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A cuproptosis-based nanomedicine suppresses triple negative breast cancers by regulating tumor microenvironment and eliminating cancer stem cells

Biomaterials, Journal Year: 2024, Volume and Issue: 313, P. 122763 - 122763

Published: Aug. 17, 2024

Language: Английский

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Decoding the “Fingerprint” of Implant Materials: Insights into the Foreign Body Reaction

Small, Journal Year: 2024, Volume and Issue: 20(23)

Published: Jan. 8, 2024

Abstract Foreign body reaction (FBR) is a prevalent yet often overlooked pathological phenomenon, particularly within the field of biomedical implantation. The presence FBR poses heavy burden on both medical and socioeconomic systems. This review seeks to elucidate protein “fingerprint” implant materials, which generated by physiochemical properties materials themselves. In this review, activity macrophages, formation foreign giant cells (FBGCs), development fibrosis capsules in context are introduced. Additionally, relationship between various elucidated detail, as an overview existing approaches technologies employed alleviate FBR. Finally, significance components (metallic non‐metallic materials), surface CHEMISTRY (charge wettability), physical characteristics (topography, roughness, stiffness) establishing also well documented. conclusion, aims emphasize importance provides current perspectives developing with anti‐FBR properties.

Language: Английский

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Graphene oxide-engineered chitosan nanoparticles: Synthesis, properties, and antibacterial activity for tissue engineering and regenerative medicine

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160852 - 160852

Published: Feb. 1, 2025

Language: Английский

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Magnetic Control of Multiscale Ligand Nanoarchitecture Regulates Stem Cell Fate

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Abstract Native tissues exhibit hierarchical structures of anisotropically arranged extracellular matrix that dynamically regulate stem cells and tissue function. However, neither multiscale nano‐anisotropy nor dynamic anisotropy control have been reported. In this study, spherical or rod‐shaped gold small‐nanomaterials (at integrin receptor‐scale; tens nanometers) are coupled to the surface magnetic large‐nanomaterials focal adhesion complex‐scale; hundreds nanometers), with both showing constant areas at each respective scale. Each nanocomposite is flexibly conjugated substrate material densities, resulting in dual‐scale liganded nano‐anisotropies. Increasing aspect ratio nanomaterials nanometer‐scale dominantly promotes recruitment, adhesion, mechanotransduction, differentiation over nanometer‐scale. Such scale‐specific effects on cell regulation temporally regulated vitro vivo by physically raising lowering nanocomposites respectively inhibit stimulate curved surfaces modulating membrane bending. unprecedented “dynamic ligand anisotropy” can be independently engineered regarding scales, anisotropies, ligands elucidate cell‐material interactions allow for multimodal enhance tissue‐regenerative therapy.

Language: Английский

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Interaction Regularity of Biomolecules on Mg and Mg-Based Alloy Surfaces: A First-Principles Study

Coatings, Journal Year: 2023, Volume and Issue: 14(1), P. 25 - 25

Published: Dec. 25, 2023

Adsorbed molecules can modulate the behavior of magnesium (Mg) and Mg alloy in biomedical applications. The interaction regularity mechanism biomolecules (such as amino acids, dipeptides, tripeptide) on a Mg(0001) surface, influence dipole correction, effects alloying elements electronic structure were investigated this study using first-principles calculations. Specifically, adsorption energy (Eads) functional groups (-NH2, -COOH -CN3H4), acids (arginine (Arg), glycine (Gly), aspartic acid (Asp)), dipeptides (arginine–glycine (Arg-Gly), glycine–aspartic (Gly-Asp), arginine–aspartic (Arg-Asp)), arginine–glycine–aspartic (RGD) tripeptide systematically calculated. Dipole correction slightly enhanced between surfaces, but Eads trend remained unchanged. addition improved Mg-based surfaces. This will be fundamental importance understanding surfaces provide possibilities for surface modification design materials.

Language: Английский

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Simvastatin-Loaded Polymeric Nanoparticles: Targeting Inflammatory Macrophages for Local Adipose Tissue Browning in Obesity Treatment

ACS Nano, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 29, 2024

Obesity is defined as chronic, low-grade inflammation within specific tissues. Given the escalating prevalence of obesity among individuals all ages, has reached epidemic proportions, posing an important public health challenge. Despite significant advancements in treating obesity, conventional approaches remain largely ineffective or involve severe side effects, thus underscoring pressing need to explore and develop treatment approaches. Targeted local immunomodulation using nanoparticles (NPs) can influence fat production utilization processes. Statins, known for their anti-inflammatory properties, show potential mitigating obesity-related inflammation. A localized delivery option offers several advantages over oral parenteral methods. Here, we developed simvastatin (Sim) encapsulated PLGA NPs (Sim-NP) Sim adipose tissues (ATs) treat obesity. In vitro experiments revealed strong effects Sim-NPs, which resulted enhanced modulation macrophage (MΦ) polarization induction AT browning. We then extended our investigation

Language: Английский

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“Mix‐and‐Match”: Self‐Sorting Assembly Governed Supramolecular Polymeric Nanomedicine for Boosting Combined Chemo/Phototherapy

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Abstract Precise cancer nanomedicine requires rational molecular instructions of therapeutic agents. Harnessing the structure‐property‐function relationships represents a practical strategy toward smart and effective nanomedicine. A structurally novel hydrogen‐bonded (H‐bonded) supramolecular nanoformulation generated by orthogonal self‐sorting assembly chemo‐prodrug (FPtF) phototherapeutics (BPeB) is here reported, to reach an autonomous with improved anti‐tumor efficacy combining chemo/phototherapy (CT/PT). The high‐fidelity H‐bonding modularity from privileged heterocomplementary diaminopyridine/5‐fluorouracil (DAP/FU) Hamilton wedge/barbiturate (HW/Ba) pairs, respectively enable precise spatial control binding interactions FPtF BPeB, in turn allowing process specific “mix‐and‐match” capability. To directly stimulate phototherapy BPeB via near‐infrared (NIR) light, spectral matched upconversion nanoparticles (UCNPs, β‐NaYF 4 :Yb,Er) are encapsulated simultaneously. As result, polymeric nanomicelles, i.e., F/B/U@PHDO, readily fabricated. Moreover, distinct association constant (Ka) DAP/FU (≈10 2 M −1 ) HW/Ba 4‐5 pairs reflect different strengths stabilities H‐bonds, thus endowing programmable dissociation, accompanied release through pH/thermal‐stimuli. Therapeutic regime appreciated outcomes ultimately accomplished combined CT/PT. opportunities offered design anticipated point new paradigm for therapy.

Language: Английский

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