Neural interfaces: Bridging the brain to the world beyond healthcare

Exploration, Год журнала: 2024, Номер 4(5)

Опубликована: Март 14, 2024

Abstract Neural interfaces, emerging at the intersection of neurotechnology and urban planning, promise to transform how we interact with our surroundings communicate. By recording decoding neural signals, these interfaces facilitate direct connections between brain external devices, enabling seamless information exchange shared experiences. Nevertheless, their development is challenged by complexities in materials science, electrochemistry, algorithmic design. Electrophysiological crosstalk mismatch electrode rigidity tissue flexibility further complicate signal fidelity biocompatibility. Recent closed‐loop brain‐computer while promising for mood regulation cognitive enhancement, are limited accuracy adaptability user interfaces. This perspective outlines challenges discusses progress contrasting non‐invasive invasive approaches, explores dynamics stimulation interfacing. Emphasis placed on applications beyond healthcare, highlighting need implantable high‐resolution capabilities.

Язык: Английский

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Bioelectronics for electrical stimulation: materials, devices and biomedical applications

Chemical Society Reviews, Год журнала: 2024, Номер 53(17), С. 8632 - 8712

Опубликована: Янв. 1, 2024

Bioelectronics is a hot research topic, yet an important tool, as it facilitates the creation of advanced medical devices that interact with biological systems to effectively diagnose, monitor and treat broad spectrum health conditions. Electrical stimulation (ES) pivotal technique in bioelectronics, offering precise, non-pharmacological means modulate control processes across molecular, cellular, tissue, organ levels. This method holds potential restore or enhance physiological functions compromised by diseases injuries integrating sophisticated electrical signals, device interfaces, designs tailored specific mechanisms. review explains mechanisms which ES influences cellular behaviors, introduces essential principles, discusses performance requirements for optimal systems, highlights representative applications. From this review, we can realize based bioelectronics therapy, regenerative medicine rehabilitation engineering technologies, ranging from tissue neurological modulation cardiovascular cognitive functions. underscores versatility various biomedical contexts emphasizes need adapt complex clinical landscapes addresses.

Язык: Английский

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Fast Electrodeposition of MXene/PDA Composites for High‐Performance Bioelectronic Interfaces: An In Vitro Evaluation

Advanced Functional Materials, Год журнала: 2024, Номер 34(23)

Опубликована: Фев. 14, 2024

Abstract Bioelectrode is critical to many biomedical researches. However, traditional materials (typically noble metals) and manufacturing techniques limit the large‐scale production of bioelectrodes. Herein, a fast electrochemical approach proposed deposit versatile MXene/polydopamine (PDA) composites on metalized substrate. PDA coating can improve adhesion between MXene substrate, while provides rough surfaces with unique micro/nanostructure outstanding electrical/optical/thermal performance. The impedance as‐prepared bioelectrode at 1 kHz down 8.48 Ω cm 2 . corresponding cathodic charge storage capacity (CSC c ) injection (CIC) are up ≈250 6.59 mC −2 respectively, much superior that bare Pt other conventional material‐based electrodes. MXene/PDA also demonstrate robust stability under continuous electrostimulation for × 10 8 pulse cycles 1000 CV cycles. Moreover, show high rapid photothermal response. Photoelectrochemical activity observed photocurrent, ≈40 folds larger than Pt. utility this new electrode in ascorbic acid sensing demonstrated. Excellent biocompatibility verified via neuron test viability assay.

Язык: Английский

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Stretchable, Self-Rolled, Microfluidic Electronics Enable Conformable Neural Interfaces of Brain and Vagus Neuromodulation

ACS Nano, Год журнала: 2024, Номер 18(2), С. 1702 - 1713

Опубликована: Янв. 2, 2024

Implantable neuroelectronic interfaces have gained significant importance in long-term brain-computer interfacing and neuroscience therapy. However, due to the mechanical geometrical mismatches between electrode-nerve interfaces, personalized compatible neural remain serious issues for peripheral neuromodulation. This study introduces stretchable flexible electronics class as a self-rolled interface neurological diagnosis modulation. These are made from liquid metal-polymer conductors with high resolution of 30 μm using microfluidic printing technology. They exhibit conformability stretchability (over 600% strain) during body movements good biocompatibility implantation 8 weeks). offer real-time monitoring epileptiform activities excellent soft brain tissue. The also develops electrodes that tightly wind deforming nerves minimal constraint (160 diameter).

Язык: Английский

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Advances in Material‐Assisted Electromagnetic Neural Stimulation

Advanced Materials, Год журнала: 2024, Номер 36(26)

Опубликована: Апрель 10, 2024

Bioelectricity plays a crucial role in organisms, being closely connected to neural activity and physiological processes. Disruptions the nervous system can lead chaotic ionic currents at injured site, causing disturbances local cellular microenvironment, impairing biological pathways, resulting loss of functions. Electromagnetic stimulation has ability generate internal currents, which be utilized counter tissue damage aid restoration movement paralyzed limbs. By incorporating implanted materials, electromagnetic targeted more accurately, thereby significantly improving effectiveness safety such interventions. Currently, there have been significant advancements development numerous promising strategies with diverse materials. This review provides comprehensive summary fundamental theories, modulating material application strategies, pre-clinical therapeutic effects associated for repair. It offers thorough analysis current techniques that employ materials enhance stimulation, as well potential future applications.

Язык: Английский

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Recent Advances in Multi‐Scale Piezoresistive Interfaces for MXene‐Based Flexible Sensors

Advanced Materials Technologies, Год журнала: 2024, Номер 9(8)

Опубликована: Фев. 21, 2024

Abstract Flexible piezoresistive sensors hold great promise in biomedicine and personal motion detection, attracting significant attention from researchers. Particularly, two‐dimensional (2D) MXene has made remarkable strides biomedicine, electromagnetic shielding, other practical applications, due to its exceptional hydrophilicity, biocompatibility, mechanical properties, surface functional groups, large specific area. The ease of composite material formation further makes it ideal for high‐sensitivity flexible sensors. This paper summarizes the principal structural configurations multi‐scale interfaces, performance assessment metrics, corresponding sensing mechanisms Subsequently, main characteristics synthesis methods MXene, especially related applications parameters are introduced detail. research trends typical MXene‐based focused on film structures, fiber 3D hydrogel highlighted systematically. In addition, challenges prospects that promoting advancement future also discussed, which will revolutionize field offer a wealth opportunities beyond.

Язык: Английский

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Hydrogels for next generation neural interfaces

Communications Materials, Год журнала: 2024, Номер 5(1)

Опубликована: Июнь 12, 2024

Abstract Overcoming the mechanical disparities between implantable neural electrodes and biological tissue is crucial in mitigating immune responses, reducing shear motion, ensuring durable functionality. Emerging hydrogel-based interfaces, with their volumetric capacitance, customizable conductivity, tissue-mimicking properties, offer a more efficient, less detrimental, chronically stable alternative to rigid counterparts. Here, we provide an overview of exceptional advantages hydrogels for development next-generation interfaces highlight recent advancements that are transforming field.

Язык: Английский

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Flexible Neural Interface From Non‐Transient Silk Fibroin With Outstanding Conformality, Biocompatibility, and Bioelectric Conductivity

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Сен. 23, 2024

Silk fibroin (SF) with good biocompatibility can enable an efficient and safe implementation of neural interfaces. However, it has been difficult to achieve a robust integration patterned conducting materials (multichannel electrodes) on flexible SF film substrates due the absence some enduring interactions. In this study, thermo-assisted pattern-transfer technique is demonstrated that facilely transfer layer pre-set poly(3,4-ethylenedioxythiophene) (PEDOT) onto substrate through interpenetrating network 2 polymer chains, achieving desired substrate/conductor intertwined interface flexibility (≈33 MPa), conductivity (386 S cm

Язык: Английский

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An insect-based bioelectronic sensing system combining flexible dual-sided microelectrode array and insect olfactory circuitry for human lung cancer detection.

Biosensors and Bioelectronics, Год журнала: 2025, Номер 281, С. 117356 - 117356

Опубликована: Март 8, 2025

Язык: Английский

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Interfacing with the Brain: How Nanotechnology Can Contribute

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Март 10, 2025

Interfacing artificial devices with the human brain is central goal of neurotechnology. Yet, our imaginations are often limited by currently available paradigms and technologies. Suggestions for brain-machine interfaces have changed over time, along technology. Mechanical levers cable winches were used to move parts during mechanical age. Sophisticated electronic wiring remote control arisen age, ultimately leading plug-and-play computer interfaces. Nonetheless, brains so complex that these visions, until recently, largely remained unreachable dreams. The general problem, thus far, most technology mechanically and/or electrically engineered, whereas a living, dynamic entity. As result, worlds difficult interface one another. Nanotechnology, which encompasses engineered solid-state objects integrated circuits, excels at small length scales single few hundred nanometers and, thus, matches sizes biomolecules, biomolecular assemblies, cells. Consequently, we envision nanomaterials nanotools as opportunities in alternative ways. Here, review existing literature on use nanotechnology look forward discussing perspectives limitations based authors' expertise across range complementary disciplines─from neuroscience, engineering, physics, chemistry biology medicine, science mathematics, social jurisprudence. We focus but also include information from related fields when useful complementary.

Язык: Английский

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