Talanta, Год журнала: 2024, Номер 285, С. 127438 - 127438
Опубликована: Дек. 24, 2024
Язык: Английский
Materials Today Bio, Год журнала: 2025, Номер unknown, С. 101667 - 101667
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Biosensors, Год журнала: 2025, Номер 15(4), С. 207 - 207
Опубликована: Март 24, 2025
Early diagnosis of diseases would significantly increase the survival rate cancer patients. However, current screening methods are complex and costly, making them unsuitable for rapid health in daily life. Here, we develop a portable platform based on planar-gate graphene field-effect transistor functionalized with polydopamine self-assembled film (PDA-GFET), capable identifying colon through detection EpCAM protein, which is expressed cancer-derived exosomes, clinical samples within 10 min. The PDA gate surface enhances biosensor’s functionalization area while suppressing non-specific adsorption, thereby achieving limits as low 112 particles/mL. In addition, PDA-GFET-based was used to identify protein real from healthy individuals patients min, two showed significant differences (p < 0.001). Results indicate that proposed expected be potential tool early cancer.
Язык: Английский
Процитировано
0
Advanced Devices & Instrumentation, Год журнала: 2024, Номер 5
Опубликована: Янв. 1, 2024
Optical microcavities are compact structures that confine resonant photons in microscale dimensions for long periods of time, greatly enhancing light–matter interactions. Plentiful and profound physical mechanisms within these or functional have been extensively explored, including mode shift/splitting/broadening, lasing gain enhancements, surface plasmon resonance, fluorescence resonance energy transferring, optical frequency comb spectroscopy, optomechanical interaction, exceptional point. The versatility design the diverse range materials, particularly composites involving metals 2-dimensional paved a way innovative approaches improved performance biochemical sensing applications. Leveraging advantages ranging from miniaturization, high sensitivity, rapid response, inherent stability, microcavity-based sensors emerged to address growing increasingly complex demands detection. This review commences with an exploration fundamental then delves into typical applications recent advancements, covering detection biomacromolecules, cells, solid particles, liquid ions, gas molecules. also culminates forward-looking perspective, highlighting future development trends crucial research directions.
Язык: Английский
Процитировано
3
Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(41)
Опубликована: Июль 22, 2024
Given the high degree of variability and complexity cancer, precise monitoring logical analysis different nucleic acid markers are crucial for improving diagnostic precision patient survival rates. However, existing molecular methods normally suffer from cost, cumbersome procedures, dependence on specialized equipment requirement in-depth expertise in data analysis, failing to analyze multiple cancer-associated provide immediate results a point-of-care manner. Herein, we demonstrate transistor-based DNA computing (TDMC) platform that enables simultaneous detection microRNA (miRNA) single transistor. TDMC can perform not only basic operations such as "AND" "OR", but also complex cascading computing, opening up new dimensions multi-index analysis. Owing efficiency, sensing computations multi-analytes be operated transistor at concentration low 2×10
Язык: Английский
Процитировано
3
Biosensors and Bioelectronics, Год журнала: 2024, Номер 266, С. 116695 - 116695
Опубликована: Авг. 30, 2024
Язык: Английский
Процитировано
2
Sensors, Год журнала: 2023, Номер 23(21), С. 8764 - 8764
Опубликована: Окт. 27, 2023
Coronavirus disease 2019 (COVID-19) is a caused by the infectious agent of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). The primary method diagnosing SARS-CoV-2 nucleic acid detection, but this requires specialized equipment and time consuming. Therefore, sensitive, simple, rapid, low-cost diagnostic test needed. Graphene field-effect transistor (GFET) biosensors have become most promising technology for detecting due to their advantages high sensitivity, fast-detection speed, label-free operation, low detection limit. This review mainly focus on three types GFET detect SARS-CoV-2. can quickly identify within ultra-low limits. Finally, we will outline pros cons approaches as well future directions.
Язык: Английский
Процитировано
6
Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 12
Опубликована: Фев. 21, 2024
Implantable and wearable bioelectronic systems are arising growing interest in the medical field. Linking microelectronic (electronic conductivity) biological (ionic worlds, biocompatible conductive materials at electrode/tissue interface key components these systems. We herein focus more particularly on resorbable systems, which can safely degrade environment once they have completed their purpose, namely, stimulating or sensing activity tissues. Resorbable also explored fields of tissue engineering 3D cell culture. After a short description polymer-based substrates scaffolds, electrical conductors, we review how be combined to design materials. Although still emerging, various biomedical applications already taking shape that profoundly modify post-operative wound healing follow-up. Future challenges perspectives field proposed.
Язык: Английский
Процитировано
1
Chinese Science Bulletin (Chinese Version), Год журнала: 2024, Номер unknown
Опубликована: Апрель 1, 2024
晶体管基生物传感是一种结合生物受体识别功能,利用场效应晶体管器件(field-effect transistor, FET)作为信号放大和转导单元,实现生物分子或小分子特异性检测的分析方法. FET生物传感器具备响应快、无标签、高灵敏、易操作和易集成等多重优势,在疾病筛查和健康监测等生物医学领域展现出巨大的应用潜力. 本文总结了近十年在高性能FET生物传感器开发方面已取得的显著成果,重点关注于FET电学分析平台的界面调控策略和生物医学应用. 首先,我们讨论了传感元件、传感界面的调制以及识别元件的设计等界面工程改造策略. 进一步,我们对FET电学分析平台在体外检测和生理环境实时监测方面的应用进行了全面总结. 最后,我们深入探讨了FET电学分析平台在实际应用方面所面临的关键机遇和挑战,旨在为高性能FET生物传感平台和生物电子器件的设计、开发和应用提供参考.
Процитировано
1
Chemical Research in Chinese Universities, Год журнала: 2024, Номер 40(2), С. 213 - 224
Опубликована: Фев. 28, 2024
Язык: Английский
Процитировано
0
Advanced Functional Materials, Год журнала: 2024, Номер unknown
Опубликована: Апрель 5, 2024
Abstract Bioartificial livers have showcased significant value in the treatment of acute liver failure (ALF). Current efforts are directed toward overcoming challenges development microcarriers, with a specific emphasis on integrating higher‐density cells to enhance detoxification capabilities. Here, inspired by radial filtration model hepatic lobules, ion‐specific silk fibroin microcarriers proposed biomimetic niches for cultivating functional at high density. These generated capillary microfluidic device controllable adjustments ion type or concentration within aqueous phase. When human induced pluripotent stem cell ‐differentiated mature these recrystallized notably enhanced proliferation activity, as well increased metabolic and secretory functionality is observed. Based features, microcarrier‐integrated bioreactor can effectively reduce transaminase levels significantly improve urea, albumin production, survival rate rabbit ALF models demonstrated. Thus, it believed that their derived may hold potential clinical applications managing other diseases.
Язык: Английский
Процитировано
0