The Optimization of Culture Conditions for Injectable Recombinant Collagen Hydrogel Preparation Using Machine Learning

Gels, Год журнала: 2025, Номер 11(2), С. 141 - 141

Опубликована: Фев. 17, 2025

Injectable recombinant collagen hydrogels (RCHs) are crucial in biomedical applications. Culture conditions play an important role the preparation of hydrogels. However, determining characteristics under certain and optimal swiftly still remain challenging tasks. In this study, a machine learning approach was introduced to explore correlation between hydrogel culture determine conditions. The study focused on four key factors as independent variables: initial substrate concentration, reaction temperature, pH level, time, while dependent variable elastic modulus To analyze impact these modulus, mathematical models were employed, including multiple linear regression (ML), decision tree (DT), support vector (SVM), neural network (NN). theoretical outputs NN closest actual values. Therefore, proved be most suitable model. Subsequently, identified concentration 15% (W/V), temperature 4 °C, 7.0, time 12 h. prepared specific exhibited predicted 15,340 Pa, approaching that natural cartilage.

Язык: Английский

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Bionic Hydrogel-based Stretchable Devices for Bioelectronics Applications

Journal of Bionic Engineering, Год журнала: 2025, Номер unknown

Опубликована: Фев. 19, 2025

Язык: Английский

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Regional‐Specific Decellularized Meniscus Extracellular Matrix Elastic Nanofiber Aerogels Regulate Meniscal Regeneration and Vascularization

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 21, 2025

Abstract The meniscus is a heterogeneous structure with spatial distribution of cells and vessels. Promoting healing remains challenging, especially in its avascular inner region. ideal repair mode shall promote while maintaining local avascularity to prevent pathological changes from vascular invasion. Given the natural biochemical components native meniscus, decellularized extracellular matrix (dmECM) shows promise for repair. Compared homogeneous dmECM, regional‐specific dmECM (RS‐dmECM) appears offer greater potential constructing structures. Furthermore, there currently no study on effects RS‐dmECM vascularization. Thus, prepared found dmECM‐Outer induced stem fibrochondrogenic differentiation, dmECM‐Inner chondrogenic differentiation inhibited angiogenesis through suppressing peroxisome proliferators‐activated receptors signaling pathway. Subsequently, poly(lactic acid)/gelatin/dmECM elastic 3D nanofiber aerogels (PG‐dmECM) are fabricated meniscal area defects rabbit model. PG‐Outer promotes fibrocartilage regeneration without significant effect In contrast, PG‐Inner achieves cartilage inhibits Moreover, compressive stress can reach 117 kPa, comparable that area. This may have within

Язык: Английский

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Bioinspired design of strong, tough and slippery hydrogels beyond the natural soft tissues

Materials Today Chemistry, Год журнала: 2025, Номер 45, С. 102633 - 102633

Опубликована: Март 9, 2025

Язык: Английский

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Enhanced interlayer adhesion and regulated tribological behaviors of 3D printed poly(ether ether ketone) by annealing

Tribology International, Год журнала: 2024, Номер 202, С. 110362 - 110362

Опубликована: Ноя. 2, 2024

Язык: Английский

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Design Strategy, On-Demand Control, and Biomedical Engineering Applications of Wet Adhesion

Langmuir, Год журнала: 2024, Номер 40(49), С. 25729 - 25757

Опубликована: Ноя. 22, 2024

The adhesion of tissues to external devices is fundamental numerous critical applications in biomedical engineering, including tissue and organ repair, bioelectronic interfaces, adhesive robotics, wearable electronics, sensing actuation, as well medical monitoring, treatment, healthcare. A key challenge this context that are typically situated aqueous dynamic environments, which poses a bottleneck further advancements these fields. Wet technology (WAT) presents an effective solution issue. In review, we summarize the three major design strategies control methods wet adhesion, comprehensively systematically introducing latest WAT field engineering. First, single mechanism under frameworks introduced. Second, for summarized, spatiotemporal control, detachment reversible control. Third, systematic summary discussion engineering research education were presented, with particular focus on innovative such tissue-electronic interface devices, ingestible end-effector components, vivo microrobots, instruments equipment. Finally, opportunities challenges encountered development adhesives advanced performance application prospects discussed.

Язык: Английский

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Biomolecule-based hydrogels as delivery systems for limbal stem cell transplantation: A review

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 280, С. 135778 - 135778

Опубликована: Сен. 18, 2024

Язык: Английский

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High performance soft fiber-reinforced sodium alginate/polyacrylamide double-network hydrogels

Progress in Natural Science Materials International, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 1, 2024

Язык: Английский

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