ACS Applied Optical Materials,
Год журнала:
2024,
Номер
2(8), С. 1474 - 1487
Опубликована: Апрель 10, 2024
Typically,
all
the
normal
as
well
cancer
cells
in
body
secrete
extracellular
vesicles
(EVs),
with
different
types
of
secreting
EVs
to
induce
specific
biological
effects
cells.
In
addition,
exhibit
characteristics
high
abundance
and
stability
are
not
easily
degradable,
rendering
them
candidate
carriers
for
diagnostic
therapeutic
clinical
interventions
future.
However,
targeting
efficacy
bioaccumulation
require
further
evaluation
detail.
Current
studies
predominantly
employ
antibodies
tracking
biodistribution
EVs.
coated
on
outer
membrane
EVs,
leading
interactions
between
exposed
protein
regions
molecules
microenvironment,
affecting
distribution
The
current
study
employs
persistent
luminescence
nanoparticles
(PLNs)
emitting
near-infrared
(NIR)
region
over
an
extended
duration.
Excitation
PLNs
can
be
accomplished
vitro
using
ultraviolet
light.
NIR
photobiological
imaging
1–9
h
following
intravenous
injection
mice
provides
a
system
long-term
situ
tumor
tracking.
synthesis
involves
use
mesoporous
silica
template;
uniform
particle
size
enhances
exocytosis
subjected
electrochemical
technology
Transwell
cell
electroporation
(TCE).
enhanced
promotes
secretion
numerous
PLN-embedded
(PLN@EVs)
into
culture
medium,
which
subsequently
purified
by
ultracentrifugation.
PLN@EVs
employed
just
tool
but
also
tumor-homing
platform;
production
large
quantities
traceable
their
tissues
such
nonsmall
lung
would
greatly
facilitate
diagnosis
cancer.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
12
Опубликована: Янв. 31, 2024
Metal-organic
frameworks
(MOFs),
with
biocompatible
and
bio-friendly
properties,
exhibit
intriguing
potential
for
the
drug
delivery
system
imaging-guided
synergistic
cancer
theranostics.
Even
though
tremendous
attention
has
been
attracted
on
MOFs-based
therapeutics,
which
play
a
crucial
role
in
therapeutic
drugs,
gene,
biomedical
agents
of
therapy,
they
are
often
explored
as
simple
nanocarriers
without
further
“intelligent”
functions.
Herein,
Fe-doped
MOFs
CoP
nanoparticles
loading
were
rationally
designed
synthesized
photothermal
enhanced
reactive
oxygen
species
(ROS)-mediated
treatment.
Fe-ZIFs@CoP
could
generate
efficient
ROS
through
Fenton
reaction
while
depleting
glutathione
amplifying
oxidative
stress.
Particularly,
due
to
effect
Fe-ZIFs@CoP,
hyperthermia
generated
by
as-synthesized
facilitated
advanced
performance
high
amount
generation.
The
promising
“all-in-one”
platform
herein
reported
provides
some
prospects
future
directions
this
area.
ACS Applied Optical Materials,
Год журнала:
2024,
Номер
2(8), С. 1474 - 1487
Опубликована: Апрель 10, 2024
Typically,
all
the
normal
as
well
cancer
cells
in
body
secrete
extracellular
vesicles
(EVs),
with
different
types
of
secreting
EVs
to
induce
specific
biological
effects
cells.
In
addition,
exhibit
characteristics
high
abundance
and
stability
are
not
easily
degradable,
rendering
them
candidate
carriers
for
diagnostic
therapeutic
clinical
interventions
future.
However,
targeting
efficacy
bioaccumulation
require
further
evaluation
detail.
Current
studies
predominantly
employ
antibodies
tracking
biodistribution
EVs.
coated
on
outer
membrane
EVs,
leading
interactions
between
exposed
protein
regions
molecules
microenvironment,
affecting
distribution
The
current
study
employs
persistent
luminescence
nanoparticles
(PLNs)
emitting
near-infrared
(NIR)
region
over
an
extended
duration.
Excitation
PLNs
can
be
accomplished
vitro
using
ultraviolet
light.
NIR
photobiological
imaging
1–9
h
following
intravenous
injection
mice
provides
a
system
long-term
situ
tumor
tracking.
synthesis
involves
use
mesoporous
silica
template;
uniform
particle
size
enhances
exocytosis
subjected
electrochemical
technology
Transwell
cell
electroporation
(TCE).
enhanced
promotes
secretion
numerous
PLN-embedded
(PLN@EVs)
into
culture
medium,
which
subsequently
purified
by
ultracentrifugation.
PLN@EVs
employed
just
tool
but
also
tumor-homing
platform;
production
large
quantities
traceable
their
tissues
such
nonsmall
lung
would
greatly
facilitate
diagnosis
cancer.
