Extracellular Vesicles Embedded with Persistent Luminescence Nanoparticles Exhibiting Near-Infrared Emission for Long-Term Tracking in Primary Tumors DOI Creative Commons

Tsai-Lan Liao,

Kai-Hung Lin,

Fei‐Ting Hsu

et al.

ACS Applied Optical Materials, Journal Year: 2024, Volume and Issue: 2(8), P. 1474 - 1487

Published: April 10, 2024

Typically, all the normal as well cancer cells in body secrete extracellular vesicles (EVs), with different types of secreting EVs to induce specific biological effects cells. In addition, exhibit characteristics high abundance and stability are not easily degradable, rendering them candidate carriers for diagnostic therapeutic clinical interventions future. However, targeting efficacy bioaccumulation require further evaluation detail. Current studies predominantly employ antibodies tracking biodistribution EVs. coated on outer membrane EVs, leading interactions between exposed protein regions molecules microenvironment, affecting distribution The current study employs persistent luminescence nanoparticles (PLNs) emitting near-infrared (NIR) region over an extended duration. Excitation PLNs can be accomplished vitro using ultraviolet light. NIR photobiological imaging 1–9 h following intravenous injection mice provides a system long-term situ tumor tracking. synthesis involves use mesoporous silica template; uniform particle size enhances exocytosis subjected electrochemical technology Transwell cell electroporation (TCE). enhanced promotes secretion numerous PLN-embedded (PLN@EVs) into culture medium, which subsequently purified by ultracentrifugation. PLN@EVs employed just tool but also tumor-homing platform; production large quantities traceable their tissues such nonsmall lung would greatly facilitate diagnosis cancer.

Language: Английский

Synergistic metabolism intervention and immune activation for antitumor therapy by biomineralized lactate oxidase DOI

Yuxuan Ge,

Zixin Wang,

Yujia Lu

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 497, P. 154378 - 154378

Published: Aug. 3, 2024

Language: Английский

Citations

1
Prussian blue-EGCG nanoparticles for synergistic photothermal and chemo anticancer therapy in vitro DOI
Bingquan Chen,

Manni Wu,

Jiayi Qin

et al.

Dyes and Pigments, Journal Year: 2024, Volume and Issue: unknown, P. 112487 - 112487

Published: Oct. 1, 2024

Language: Английский

Citations

1
Co-delivery of vitamin and amino acid within MOFs for oxidative stress-based tumor gas therapy DOI

Xiangxuan Yan,

Peng Jing,

Zhixiang Zhuang

et al.

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 680, P. 518 - 528

Published: Nov. 19, 2024

Language: Английский

Citations

1
Rational designed Fe-ZIFs@CoP nanoplatforms for photothermal-enhanced ROS-mediated tumor therapy DOI Creative Commons
Chen Wang,

Shufang Ning,

Jinling Mai

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: Jan. 31, 2024

Metal-organic frameworks (MOFs), with biocompatible and bio-friendly properties, exhibit intriguing potential for the drug delivery system imaging-guided synergistic cancer theranostics. Even though tremendous attention has been attracted on MOFs-based therapeutics, which play a crucial role in therapeutic drugs, gene, biomedical agents of therapy, they are often explored as simple nanocarriers without further “intelligent” functions. Herein, Fe-doped MOFs CoP nanoparticles loading were rationally designed synthesized photothermal enhanced reactive oxygen species (ROS)-mediated treatment. Fe-ZIFs@CoP could generate efficient ROS through Fenton reaction while depleting glutathione amplifying oxidative stress. Particularly, due to effect Fe-ZIFs@CoP, hyperthermia generated by as-synthesized facilitated advanced performance high amount generation. The promising “all-in-one” platform herein reported provides some prospects future directions this area.

Language: Английский

Citations

0
Extracellular Vesicles Embedded with Persistent Luminescence Nanoparticles Exhibiting Near-Infrared Emission for Long-Term Tracking in Primary Tumors DOI Creative Commons

Tsai-Lan Liao,

Kai-Hung Lin,

Fei‐Ting Hsu

et al.

ACS Applied Optical Materials, Journal Year: 2024, Volume and Issue: 2(8), P. 1474 - 1487

Published: April 10, 2024

Typically, all the normal as well cancer cells in body secrete extracellular vesicles (EVs), with different types of secreting EVs to induce specific biological effects cells. In addition, exhibit characteristics high abundance and stability are not easily degradable, rendering them candidate carriers for diagnostic therapeutic clinical interventions future. However, targeting efficacy bioaccumulation require further evaluation detail. Current studies predominantly employ antibodies tracking biodistribution EVs. coated on outer membrane EVs, leading interactions between exposed protein regions molecules microenvironment, affecting distribution The current study employs persistent luminescence nanoparticles (PLNs) emitting near-infrared (NIR) region over an extended duration. Excitation PLNs can be accomplished vitro using ultraviolet light. NIR photobiological imaging 1–9 h following intravenous injection mice provides a system long-term situ tumor tracking. synthesis involves use mesoporous silica template; uniform particle size enhances exocytosis subjected electrochemical technology Transwell cell electroporation (TCE). enhanced promotes secretion numerous PLN-embedded (PLN@EVs) into culture medium, which subsequently purified by ultracentrifugation. PLN@EVs employed just tool but also tumor-homing platform; production large quantities traceable their tissues such nonsmall lung would greatly facilitate diagnosis cancer.

Language: Английский

Citations

0