Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
12
Опубликована: Сен. 13, 2024
Piezoelectric
materials,
as
a
class
of
materials
capable
generating
electrical
charges
under
mechanical
vibration,
have
special
piezoelectric
effects
and
been
widely
applied
in
various
disease
treatment
fields.
People
generate
vibrations
the
oral
cavity
during
daily
activities
such
brushing
teeth,
using
electric
toothbrushes,
chewing,
speaking.
These
natural
(or
external
ultrasound)
provide
ideal
conditions
for
activating
leading
to
their
high
potential
applications
protecting
health
treating
diseases.
Based
on
this,
this
review
reports
research
progress
trends
protection
diseases
past
5
years,
discusses
its
mechanism,
challenges
shortcomings,
aiming
theoretical
basis
new
ideas
future
application
field
cavity.
Finally,
brief
outlook
is
provided,
suggesting
that
may
enable
them
quickly
move
towards
real
clinical
applications.
Regenerative Biomaterials,
Год журнала:
2024,
Номер
11
Опубликована: Янв. 1, 2024
Abstract
The
intricate
nature
of
oral-maxillofacial
structure
and
function,
coupled
with
the
dynamic
oral
bacterial
environment,
presents
formidable
obstacles
in
addressing
repair
regeneration
bone
defects.
Numerous
characteristics
should
be
noticed
repair,
such
as
irregular
morphology
defects,
homeostasis
between
hosts
microorganisms
cavity
complex
periodontal
structures
that
facilitate
epithelial
ingrowth.
Therefore,
necessitates
restoration
materials
adhere
to
stringent
specific
demands.
This
review
starts
exploring
these
particular
requirements
by
introducing
bones
then
summarizes
classifications
current
respect
composition
structure.
Additionally,
we
discuss
modifications
including
improving
mechanical
properties,
optimizing
surface
topography
pore
adding
bioactive
components
elements,
compounds,
cells
their
derivatives.
Ultimately,
organize
a
range
potential
optimization
strategies
future
perspectives
for
enhancing
materials,
physical
environment
manipulation,
microbial
modulation,
osteo-immune
regulation,
smart
stimuli-responsive
multifaceted
approach
poly-pathic
treatment,
hope
providing
some
insights
researchers
this
field.
In
summary,
analyzes
demands
especially
alveolar
bone,
concludes
corresponding
biomaterials
aims
inspire
research
pursuit
more
effective
treatment
outcomes.
Biomacromolecules,
Год журнала:
2024,
Номер
25(9), С. 5541 - 5591
Опубликована: Авг. 12, 2024
The
future
development
of
wearable/implantable
sensing
and
medical
devices
relies
on
substrates
with
excellent
flexibility,
stability,
biocompatibility,
self-powered
capabilities.
Enhancing
the
energy
efficiency
convenience
is
crucial,
converting
external
mechanical
into
electrical
a
promising
strategy
for
long-term
advancement.
Poly(vinylidene
fluoride)
(PVDF),
known
its
piezoelectricity,
an
outstanding
representative
electroactive
polymer.
Ingeniously
designed
PVDF-based
polymers
have
been
fabricated
as
piezoelectric
various
applications.
Notably,
performance
platforms
determined
by
their
structural
characteristics
at
different
scales.
This
Review
highlights
how
researchers
can
strategically
engineer
structures
microscopic,
mesoscopic,
macroscopic
We
discuss
advanced
research
diverse
designs
in
biomedical
sensing,
disease
diagnosis,
treatment.
Ultimately,
we
try
to
give
perspectives
trends
biomedicine,
providing
valuable
insights
further
research.
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 31, 2024
Abstract
Endogenous
electric
field
(EEF)
is
weakened
in
wounds
due
to
electrolyte
loss,
hindering
wound
repair.
Reshaping
and
repairing
EEF
play
important
roles
accelerating
healing.
The
design
of
antibacterial
dressings
coupled
with
an
recovery
ability
promote
healing
urgent
significant.
Herein,
a
self‐powered
wearable
thermoelectric
dressing
antibacterial,
antioxidant,
reshaping
activities
for
methicillin‐resistant
Staphylococcus
aureus
‐infected
therapy
fabricated.
based
on
device
constructed
polyanionic
hydrogel
loaded
tannic
acid
(TA).
By
taking
advantage
the
natural
temperature
difference
between
infected
external
environment,
activated
convert
thermal
energy
into
electricity,
producing
continuous
compensating
reshape
damaged
stimulate
tissue
regeneration.
Combined
antioxidant
properties
TA
released
from
hydrogel,
can
accelerate
vivo
by
topical
targeted
sterilization,
reducing
inflammation
wounds.
Thus,
this
provides
promising
facile
therapeutic
strategy
without
need
stimuli
treat
Effectively
addressing
inflammation
in
periodontitis
is
challenging
as
conventional
injectable
hydrogels
typically
require
the
addition
of
drugs
to
provide
sufficient
anti-inflammatory
effects.
To
overcome
this
limitation,
we
developed
a
multifunctional
hydrogel
with
inherent
properties
that
antagonize
Toll-like
receptor
4
and
myeloid
differentiation
factor
2
complex
(TLR4-MD2).
This
allows
for
direct
inhibition
inflammatory
pathways
without
need
additional
drugs.
We
identified
xylitol,
caffeic
acid,
citric
acid
natural
materials
effectively
meet
biological
needs
antibacterial
effects
well
support
bone
regeneration.
With
mind,
caffeic-acid-modified
poly(xylitol
succinate)
(PXS)-based
iCPC@MgO
composite
tested
its
potential
application
periodontal
The
demonstrated
rapid
wet
tissue
adhesion
injectability,
which
are
ascribed
incorporating
catechol
groups
derived
from
acid.
Intriguingly,
PXS
polymer
used
synthesizing
was
found
possess
act
an
antagonist
TLR4-MD2
complex.
also
exhibited
outstanding
efficiency
against
Porphyromonas
gingivalis
Aggregatibacter
actinomycetemcomitans
by
stimulating
antibiotic
synthesis
within
bacteria
disrupting
bacterial
cell
walls.
In
mouse
model,
therapeutic
reducing
factors,
inhibiting
dominant
periodontitis-associated
bacteria,
maintaining
subgingival
microbiota
balance
regenerative
These
properties,
combined
their
ecofriendly
nature,
firmly
established
highly
promising
option
use
therapy
healing,
repair,
regeneration
various
other
conditions.
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 26, 2025
An
ideal
guided
bone
regeneration
(GBR)
membrane
for
periodontitis
treatment
should
incorporate
biocompatibility,
biodegradability,
mechanical
strength,
antibacterial
properties,
and
osteoconductivity.
However,
no
commercially
available
GBR
meets
all
these
criteria
simultaneously.
In
this
study,
a
novel
biodegradable
piezoelectric
double-layered
is
developed,
with
non-piezoelectric
Poly-L-lactic
acid
(PLLA)
side
facing
the
gingiva
PLLA-ZnO
alveolar
bone.
This
asymmetric
membrane,
distinct
fiber
orientations
charge
distribution,
combines
synergizes
degradability,
barrier
function,
activity
osteogenic
potential
to
enhance
efficacy.
The
can
effectively
prevent
fibroblast
migration,
inhibits
bacterial
infection,
promotes
both
in
vitro
vivo.
testing
shows
good
rate
against
Porphyromonas
gingivalis
(P.
gingivalis)
Staphylococcus
aureus
(S.
aureus)
after
10
min
of
ultrasound
stimulation.
Expression
levels
genes
Bone
morphogenetic
Protein
2
(BMP2),
Runt-related
transcription
factor
(RUNX2),
Osteopontin
(OPN)
Osteocalcin
(OCN)
are
over
twice
that
control.
mouse
P.
gingivalis-mediated
model,
our
composite
demonstrates
effective
antimicrobial
effects
promote
2-
4-weeks
implantation,
facilitated
by
mechanisms
such
as
physical
isolation,
zinc
ion
release,
effects,
enhanced
expression
through
activation
osteogenesis-related
signaling
pathways,
underscoring
its
strong
applications.
