Research progress of piezoelectric materials in protecting oral health and treating oral diseases: a mini-review DOI Creative Commons
Tingyu Yang, Rina Sa, Furong Wang

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: Sept. 13, 2024

Piezoelectric materials, as a class of materials capable generating electrical charges under mechanical vibration, have special piezoelectric effects and been widely applied in various disease treatment fields. People generate vibrations the oral cavity during daily activities such brushing teeth, using electric toothbrushes, chewing, speaking. These natural (or external ultrasound) provide ideal conditions for activating leading to their high potential applications protecting health treating diseases. Based on this, this review reports research progress trends protection diseases past 5 years, discusses its mechanism, challenges shortcomings, aiming theoretical basis new ideas future application field cavity. Finally, brief outlook is provided, suggesting that may enable them quickly move towards real clinical applications.

Language: Английский

Advances in biomaterials for oral-maxillofacial bone regeneration: spotlight on periodontal and alveolar bone strategies DOI Creative Commons

N. Li,

Jinyu Wang,

Guangxia Feng

et al.

Regenerative Biomaterials, Journal Year: 2024, Volume and Issue: 11

Published: Jan. 1, 2024

Abstract The intricate nature of oral-maxillofacial structure and function, coupled with the dynamic oral bacterial environment, presents formidable obstacles in addressing repair regeneration bone defects. Numerous characteristics should be noticed repair, such as irregular morphology defects, homeostasis between hosts microorganisms cavity complex periodontal structures that facilitate epithelial ingrowth. Therefore, necessitates restoration materials adhere to stringent specific demands. This review starts exploring these particular requirements by introducing bones then summarizes classifications current respect composition structure. Additionally, we discuss modifications including improving mechanical properties, optimizing surface topography pore adding bioactive components elements, compounds, cells their derivatives. Ultimately, organize a range potential optimization strategies future perspectives for enhancing materials, physical environment manipulation, microbial modulation, osteo-immune regulation, smart stimuli-responsive multifaceted approach poly-pathic treatment, hope providing some insights researchers this field. In summary, analyzes demands especially alveolar bone, concludes corresponding biomaterials aims inspire research pursuit more effective treatment outcomes.

Language: Английский

Citations

6
Engineering the electrochemistry of a therapeutic Zn battery toward biofilm microenvironment for diabetic wound healing DOI

Runan Li,

Hongyong Xiang,

Qin Liang

et al.

Nano Energy, Journal Year: 2024, Volume and Issue: 128, P. 109946 - 109946

Published: July 2, 2024

Language: Английский

Citations

5
Ingenious Structure Engineering to Enhance Piezoelectricity in Poly(vinylidene fluoride) for Biomedical Applications DOI
Jiwei Cui,

Lijun Du,

Zhiheng Meng

et al.

Biomacromolecules, Journal Year: 2024, Volume and Issue: 25(9), P. 5541 - 5591

Published: Aug. 12, 2024

The future development of wearable/implantable sensing and medical devices relies on substrates with excellent flexibility, stability, biocompatibility, self-powered capabilities. Enhancing the energy efficiency convenience is crucial, converting external mechanical into electrical a promising strategy for long-term advancement. Poly(vinylidene fluoride) (PVDF), known its piezoelectricity, an outstanding representative electroactive polymer. Ingeniously designed PVDF-based polymers have been fabricated as piezoelectric various applications. Notably, performance platforms determined by their structural characteristics at different scales. This Review highlights how researchers can strategically engineer structures microscopic, mesoscopic, macroscopic We discuss advanced research diverse designs in biomedical sensing, disease diagnosis, treatment. Ultimately, we try to give perspectives trends biomedicine, providing valuable insights further research.

Language: Английский

Citations

5
Piezotronic effect enhanced catalytic sterilization: mechanisms and practical applications DOI
Xiaoyu Zhang, Zhongwei Yang, Jian Zhang

et al.

Nano Energy, Journal Year: 2024, Volume and Issue: 131, P. 110346 - 110346

Published: Oct. 10, 2024

Language: Английский

Citations

4
Skin Temperature‐Activated Multifunctional Thermoelectric Dressing for Bacterial Infected Wound Treatment DOI

Shuna Gao,

Yu Rao,

Xiaowei Wang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 31, 2024

Abstract Endogenous electric field (EEF) is weakened in wounds due to electrolyte loss, hindering wound repair. Reshaping and repairing EEF play important roles accelerating healing. The design of antibacterial dressings coupled with an recovery ability promote healing urgent significant. Herein, a self‐powered wearable thermoelectric dressing antibacterial, antioxidant, reshaping activities for methicillin‐resistant Staphylococcus aureus ‐infected therapy fabricated. based on device constructed polyanionic hydrogel loaded tannic acid (TA). By taking advantage the natural temperature difference between infected external environment, activated convert thermal energy into electricity, producing continuous compensating reshape damaged stimulate tissue regeneration. Combined antioxidant properties TA released from hydrogel, can accelerate vivo by topical targeted sterilization, reducing inflammation wounds. Thus, this provides promising facile therapeutic strategy without need stimuli treat

Language: Английский

Citations

4
Charged substrate treatment enhances T cell mediated cancer immunotherapy DOI Creative Commons
Jia Song,

Yanhui Lu,

Lulu Liu

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 12, 2025

Biophysical cues play a crucial role in T cell biology, yet their implications adoptive therapy (ACT) remain largely unknown. Here, we investigate the effect of electrical stimuli on CD8+ cells using charged substrate composed electroactive nanocomposites with tunable surface charge intensities. Electrical enhance persistence and tumor-suppressive efficacy transferred cells, effects dependent charge. Single-cell RNA-sequencing analysis unveils decrease virtual memory (Tvm) an increase proliferative potential (Tpp) which exhibit superior antitumor activity metabolic adaptations relative to those treated uncharged substrate. ATAC-seq profiling demonstrates heightened accessibility at upstream binding sites for EGR1, transcription factor critical Tpp differentiation. Mechanistically, disrupts ionic TCR-lipid interactions, amplifies TCR signaling, activates thereby impeding Tvm polarization during ex vivo culture. Our findings thus highlight importance extracellular shaping fate, offering optimizing ACT therapeutic applications. elusive. Here authors use proliferation anti-tumor function transfer therapy, mechanism amplifying activating EGR1 signaling polarization.

Language: Английский

Citations

0
Multifunctional Injectable Bioadhesive with Toll-like Receptor 4 and Myeloid Differentiation Factor 2 Antagonistic Anti-inflammatory Potential for Periodontal Regeneration DOI Creative Commons

Shuting Gao,

Huihua Li, Zekun Li

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Effectively addressing inflammation in periodontitis is challenging as conventional injectable hydrogels typically require the addition of drugs to provide sufficient anti-inflammatory effects. To overcome this limitation, we developed a multifunctional hydrogel with inherent properties that antagonize Toll-like receptor 4 and myeloid differentiation factor 2 complex (TLR4-MD2). This allows for direct inhibition inflammatory pathways without need additional drugs. We identified xylitol, caffeic acid, citric acid natural materials effectively meet biological needs antibacterial effects well support bone regeneration. With mind, caffeic-acid-modified poly(xylitol succinate) (PXS)-based iCPC@MgO composite tested its potential application periodontal The demonstrated rapid wet tissue adhesion injectability, which are ascribed incorporating catechol groups derived from acid. Intriguingly, PXS polymer used synthesizing was found possess act an antagonist TLR4-MD2 complex. also exhibited outstanding efficiency against Porphyromonas gingivalis Aggregatibacter actinomycetemcomitans by stimulating antibiotic synthesis within bacteria disrupting bacterial cell walls. In mouse model, therapeutic reducing factors, inhibiting dominant periodontitis-associated bacteria, maintaining subgingival microbiota balance regenerative These properties, combined their ecofriendly nature, firmly established highly promising option use therapy healing, repair, regeneration various other conditions.

Language: Английский

Citations

0
Electrical stimulation of bone regeneration in infected defects: biomaterial approaches DOI

Jinwoo Na,

Hwan Kim

Macromolecular Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Language: Английский

Citations

0
Biodegradable Piezoelectric Janus Membrane with Enhanced Antibacterial and Osteoinductive Properties for Periodontitis Therapy DOI Open Access
Jingrong Cheng,

Liping Wu,

Hongying Fu

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

An ideal guided bone regeneration (GBR) membrane for periodontitis treatment should incorporate biocompatibility, biodegradability, mechanical strength, antibacterial properties, and osteoconductivity. However, no commercially available GBR meets all these criteria simultaneously. In this study, a novel biodegradable piezoelectric double-layered is developed, with non-piezoelectric Poly-L-lactic acid (PLLA) side facing the gingiva PLLA-ZnO alveolar bone. This asymmetric membrane, distinct fiber orientations charge distribution, combines synergizes degradability, barrier function, activity osteogenic potential to enhance efficacy. The can effectively prevent fibroblast migration, inhibits bacterial infection, promotes both in vitro vivo. testing shows good rate against Porphyromonas gingivalis (P. gingivalis) Staphylococcus aureus (S. aureus) after 10 min of ultrasound stimulation. Expression levels genes Bone morphogenetic Protein 2 (BMP2), Runt-related transcription factor (RUNX2), Osteopontin (OPN) Osteocalcin (OCN) are over twice that control. mouse P. gingivalis-mediated model, our composite demonstrates effective antimicrobial effects promote 2- 4-weeks implantation, facilitated by mechanisms such as physical isolation, zinc ion release, effects, enhanced expression through activation osteogenesis-related signaling pathways, underscoring its strong applications.

Language: Английский

Citations

0
Recent advances in active packaging: Insights into novel functional elements, response strategies and applications for food preservation DOI

Wenyu Lou,

Chen‐Yu Huang,

Qiong Shao

et al.

Food Packaging and Shelf Life, Journal Year: 2025, Volume and Issue: 49, P. 101489 - 101489

Published: April 4, 2025

Language: Английский

Citations

0